陈峰

发布者：生物统计学系发布时间：2017-07-18浏览次数：23026



陈峰，博士，教授，博士生导师。“国家高层次人才特殊支持计划”教学名师，江苏省有突出贡献的中青年专家。《中国卫生统计》杂志副主编。历任中国卫生统计学会（现中国卫生信息与健康医疗大数据学会）统计理论与方法专业委员会副主任委员、主任委员，卫生统计学教育专业委员会副主任委员，临床试验生物统计学工作小组(China Clinical Trial Statistics Working Group, CCTS)组长。曾任南京医科大学公共卫生学院院长、研究生院院长，江苏省第八、九、十届政协委员。从事医学统计学教学与科研工作40余年，主要研究领域为医学研究中非独立数据、生物医学高维数据、临床试验评价和分析中的统计理论与方法。主持科技部国家重点研发计划·战略性国际科技合作重点专项、国家自然科学基金重点项目、国家自然科学基金重点国际(地区)合作研究项目、国家自然科学基金专项项目、比尔及梅琳达·盖茨基金会专项项目等20余项。发表或联合发表学术论文/评论300余篇,其中SCI收录160余篇。曾获国家级教学成果奖二等奖，高等学校科学研究优秀成果奖(科学技术)自然科学奖二等奖,全国统计科研优秀成果奖二等奖等。主编、副主编国家级规划教材、全国统计规划教材、教育部推荐“研究生教学用书”及专著等10余部，培养研究生100余人。



研究方向：非独立数据、生物医学高维数据、临床研究中的统计理论与方法

联系方式：

地址：南京市江宁区龙眠大道101号南京医科大学至诚楼

电话：025-86868436

邮箱：dr.chenfeng@163.com


在研项目：

  1. 国家自然科学基金重点国际(地区)合作研究项目. 基于贝叶斯因果网络的中欧肺癌风险预测模型构建与大型前瞻性人群队列评估研究 (82220108002) 主持

  2. Gates Foundation (盖茨基金会). Study on the epidemic trend of COVID-19 infection: a cross-regional random dynamic model based on big-data (INV-006371)  PI


完成项目：

  1. 国家自然科学基金新型冠状病毒（2019-nCoV）溯源、致病及防治的基础研究专项项目：基于大数据的跨地域开放系统随机动力学模型（82041024）

  2. 国家重点研发计划战略性国际科技创新合作重点专项：基于出生队列的重金属暴露与不良出生结局的国际合作研究（2016YFE0204900）

  3. 国家自然科学基金重点项目基于人群的生物医学多层面数据整合方法及肿瘤风险预测研究（81530088）

  4. 国家自然科学基金项目：全基因组关联研究中基因-基因、基因-环境交互作用统计分析方法研究 (81473070)

  5. 国家自然科学基金项目：全基因组关联研究中的降维策略和统计分析方法研究(81072389)

  6. 江苏省高校自然科学基金重大项目：全基因组关联研究中的优化设计与降维分析策略(10KJA33034)

  7. 国家自然科学基金项目：非传统病例对照设计的统计分析方法研究(30571619)

  8. 教育部博士点基金：微阵列数据的统计分析(20050312001)

  9. 国家自然科学基金青年基金项目医学研究中非独立数据的统计分析方法(39500127)主持

  10. 国家自然科学基金项目疾病时空聚集性分析方法的研究(39470644)


教材和著作：


  • 主编：《医学统计学》（八年制及“5+3”一体化临床医学等专业用），人民卫生出版社，2024

  • 主编：《医用多元统计分析方法》(第一、二、三版)（教育部研究生推荐教材，十四五全国统计规划教材），中国统计出版社，2001,2007,2018

  • 主编：《临床试验统计学》，人民卫生出版社，2018

  • 主编：《临床试验精选案例统计学解读》，人民卫生出版社，2015

  • 主编：《现代医学统计方法与STATA应用》(第一、二版)中国统计出版社，1999,2003

  • 共同主编：《医学统计学》(陆守曾、陈峰主编) 第二、三、四版（十一五国家规划教材，十二五、十三五、十四五全国统计规划教材）,中国统计出版社，2002,2007,2022

  • 共同主编：《医用统计方法》（金丕焕、陈峰主编）(第三版)（十一五国家规划教材）复旦大学出版社，2009

  • 共同主编：《卫生统计学》（赵耐青、陈峰主编）高等教育出版社（十一五国家规划教材），2008

  • Co-Editor. Advanced Statistics in Regulatory Critical Clinical Initiatives. Chapman & Hall / CRC Biostatistics Series. 2022

  • 副主编：《卫生统计学》（第８版）（李晓松主编），国家卫生和计划生育委员会十三五规划教材. 人民卫生出版社，2017

  • Co-Editor. Handbook of Medical Statistics. World Scientific Publishing. 2017

  • 副主编：《医学统计学手册》（方积乾主编），中国统计出版社，2017

  • 副主编：《医学科研方法学》（第一、二版），人民卫生出版社，2013

  • 副主编：《临床医学研究设计和数据分析》(赵乃青主编)，复旦大学出版社，2005

  • 副主编：《医学统计学》(赵乃青主编)，十五国家规划教材，高等教育出版社，2004

  • 副主编：《卫生统计方法应用进展》(饶克勤主编)，第1卷、第2卷。人民卫生出版社，2008

  • 副主编：《出生缺陷的统计监测方法与季节性分析》(杨树勤主编)，四川科学技术出版社,1998年



代表性论文(通讯作者)：

  1.             Shen S, Li Z, Jiang Y, Duan W, Li H, Du S, Esteller M, Shen H, Hu Z, Zhao Y, Christiani DC, Chen F. A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer. Am J Respir Crit Care Med. 2023 Aug 1;208(3):280-289. doi: 10.1164/rccm.202212-2199OC. PMID: 37167549; PMCID: PMC10395715. IF=30.528

  2. Pan Z, Zhang R, Shen S, Lin Y, Zhang L, Wang X, Ye Q, Wang X, Chen J, Zhao Y, Christiani DC, Li Y, Chen F, Wei Y. OWL: an optimized and independently validated machine learning prediction model for lung cancer screening based on the UK Biobank, PLCO, and NLST populations. EBioMedicine. 2023;88:104443. IF= 11.205

  3. You D, Wang D, Wu Y, Chen X, Shao F, Wei Y, Zhang R, Lange T, Ma H, Xu H, Hu Z, Christiani DC, Shen H, Chen F, Zhao Y. Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study. BMC Med. 2022 Jun 6;20(1):203. IF= 11.15

  4. Wei L, Huang H, Chen X, Wang X, Zhang R, Su L, Duan W, Rahman M, Golam Mostofa M, Qamruzzaman Q, Shen H, Hu Z, Wei Y, Christiani DC, Chen F. Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh. Environ Int. 2022 Jun 24;166:107370. IF= 13.352

  5. Zhang R, Shen S, Wei Y, Zhu Y, Li Y, Chen J, Guan J, Pan Z, Wang Y, Zhu M, Xie J, Xiao X, Zhu D, Li Y, Albanes D, Landi MT, Caporaso NE, Lam S, Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeböller H, Wichmann HE, Rennert G, Arnold S, Brennan P, McKay JD, Field JK, Shete SS, Le Marchand L, Liu G, Andrew AS, Kiemeney LA, Zienolddiny-Narui S, Behndig A, Johansson M, Cox A, Lazarus P, Schabath MB, Aldrich MC, Dai J, Ma H, Zhao Y, Hu Z, Hung RJ, Amos CI, Shen H, Chen F, Christiani DC. A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians. Journal of Thoracic Oncology. 2022 Apr 30:S1556-0864(22)00215-5. IF= 20.121

  6. Chen J, Shen S, Li Y, Fan J, Xiong S, Xu J, Zhu C, Lin L, Dong X, Duan W, Zhao Y, Qian X, Liu Z, Wei Y, Christiani DC, Zhang R, Chen F. APOLLO: An accurate and independently validated prediction model of lower-grade gliomas overall survival and a comparative study of model performance. EBioMedicine. 2022 May;79:104007. IF= 11.205

  7. Wei Y, Sha F, Zhao Y, Jiang Q, Hao Y, Chen F. Better modelling of infectious diseases: lessons from covid-19 in China. BMJ. 2021 Dec 1;375:n2365. IF= 93.333

  8. Wei Y, Guan J, Ning X, Li Y, Wei L, Shen S, Zhang R, Zhao Y, Shen H, Chen F*. Global COVID-19 pandemic waves: Limited lessons learned worldwide over the past year. Engineering (Beijing). 2021 Sep 14. IF= 12.834

  9. Huang H, Wei L, Chen X, Zhang R, Su L, Rahman M, Golam Mostofa M, Qamruzzaman Q, Zhao Y, Yu H, Wei Y, Christiani DC, Chen F. Cord serum elementomics profiling of 56 elements depicts risk of preterm birth: Evidence from a prospective birth cohort in rural Bangladesh. Environment International. 2021 Nov;156:106731. IF= 13.352

  10. Wei Y, Huang H, Zhang R, Zhu Z, Zhu Y, Lin L, Dong X, Wei L, Chen X, Liu Z, Zhao Y, Su L, Chen F, Christiani DC. Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival. JAMA Network Open. 2021 Jan 4;4(1):e2034569. IF= 13.366

  11. Du M, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q, Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X, Wang M, Chen F, Christiani DC. Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Intensive Care Medicine. 2021 Jul;47(7):761-771. IF= 41.787

  12. Chen X, Gao W, Li J, You D, Yu Z, Zhang M, Shao F, Wei Y, Zhang R, Lange T, Wang Q, Chen F, Lu X, Zhao Y. A predictive paradigm for COVID-19 prognosis based on the longitudinal measure of biomarkers. Briefings in Bioinformatics. 2021 Nov 5;22(6):bbab206. IF=13.994

  13. Shen S, Zhang R, Jiang Y, Li Y, Lin L, Liu Z, Zhao Y, Shen H, Hu Z, Wei Y, Chen F. Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types. Molecular Cancer. 2021 Apr 13;20(1):67. IF=41.444

  14. Shen S, Wei Y, Li Y, Duan W, Dong X, Lin L, You D, Tardon A, Chen C, Field JK, Hung RJ, Liu G, Zhu D, Amos CI, Su L, Zhao Y, Hu Z, Shen H, Zhang R, Chen F, Christiani DC. A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival. NPJ Precision Oncology. 2021 May 17;5(1):39. IF= 10.169

  15. Dong X, Ma G, Chen F. Age at diagnosis and prognosis among prostate cancer patients treated with radiotherapy: evidenced from three independent cohort studies. Annals of Oncology. 2018 Sep 1;29(9):2019-2020. IF= 14.196

  16. Wei Y, Chen F. Lowering the P Value Threshold. JAMA. 2018 Sep 4;320(9):934-935. IF= 51.273


代表性论文(合作发表)：

  1. Ge Z, Kan J, Gao X, Raza A, Zhang JJ, Mohydin BS, Gao F, Shao Y, Wang Y, Zeng H, Li F, Khan HS, Mengal N, Cong H, Wang M, Chen L, Wei Y, Chen F, Stone GW, Chen SL; ULTIMATE-DAPT investigators. Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial. Lancet. 2024 May 11;403(10439):1866-1878. doi: 10.1016/S0140-6736(24)00473-2. PMID: 38599220. 

  2. Li X, Ge Z, Kan J, Anjum M, Xie P, Chen X, Khan HS, Guo X, Saghir T, Chen J, Gill BUA, Guo N, Sheiban I, Raza A, Wei Y, Chen F, Mintz GS, Zhang JJ, Stone GW, Chen SL; IVUS-ACS Investigators. Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial. Lancet. 2024 May 11;403(10439):1855-1865. doi: 10.1016/S0140-6736(24)00282-4. Epub 2024 Apr 8. PMID: 38604212.  

  3. Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L, Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, Chen F, Han Y, Xie L, Ji Y. HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression. Circulation. 2021 Aug 24;144(8):638-654. IF=39.918

  4. Qin S, Bi F, Gu S, Bai Y, Chen Z, Wang Z, Ying J, Lu Y, Meng Z, Pan H, Yang P, Zhang H, Chen X, Xu A, Cui C, Zhu B, Wu J, Xin X, Wang J, Shan J, Chen J, Zheng Z, Xu L, Wen X, You Z, Ren Z, Liu X, Qiu M, Wu L, Chen F. Donafenib Versus Sorafenib in First-Line Treatment of Unresectable or Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label, Parallel-Controlled Phase II-III Trial. J Clin Oncol. 2021 Sep 20;39(27):3002-3011. IF=50.717

  5. Fan Y, Cheng Y, Li Y, Chen B, Wang Z, Wei T, Zhang H, Guo Y, Wang Q, Wei Y, Chen F, Sha J, Guo X, Wang L. Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of Checkpoint Kinase 1 via Activating Mammalian Target of Rapamycin C1/Ribosomal Protein S6 Kinase b-1 Pathway. Circulation. 2020 May 12;141(19):1554-1569. IF=29.69

  6. Du M, Cai G, Chen F, Christiani DC, Zhang Z, Wang M. Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19. Gastroenterology. 2020 Jun;158(8):2298-2301.e7. IF= 22.682

  7. Dong X, Zhu Z, Wei Y, Ngo D, Zhang R, Du M, Huang H, Lin L, Tejera P, Su L, Chen F, Ahasic AM, Thompson BT, Meyer NJ, Christiani DC. Plasma Insulin-like Growth Factor Binding Protein 7 Contributes Causally to ARDS 28-Day Mortality: Evidence From Multistage Mendelian Randomization. Chest. 2021 Mar;159(3):1007-1018. IF=10.262

  8. Hu Z, Li Z, Yu J, Tong C, Lin Y, Guo X, Lu F, Dong J, Xia Y, Wen Y, Wu H, Li H, Zhu Y, Ping P, Chen X, Dai J, Jiang Y, Pan S, Xu P, Luo K, Du Q, Yao B, Liang M, Gui Y, Weng N, Lu H, Wang Z, Zhang F, Zhu X, Yang X, Zhang Z, Zhao H, Xiong C, Ma H, Jin G, Chen F, Xu J, Wang X, Zhou Z, Chen ZJ, Liu J, Shen H, Sha J. Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun. 2014 May 23;5:3857. IF= 11.470

  9. Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S, Chu M, Lu F, Yu D, Jiang Y, Dong J, Hu L, Chen Y, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F, Wang X, Hu Z, Lin D, Shen H. Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. Am J Hum Genet. 2012 Nov 2;91(5):928-34. IF= 11.202

  10. Zhang R, Wang Z, Tejera P, Frank AJ, Wei Y, Su L, Zhu Z, Guo Y, Chen F, Bajwa EK, Thompson BT, Christiani DC. Late-onset moderate to severe acute respiratory distress syndrome is associated with shorter survival and higher mortality: a two-stage association study. Intensive Care Med. 2017 Mar;43(3):399-407. IF=15.008

  11. Wei Y, Tejera P, Wang Z, Zhang R, Chen F, Su L, Lin X, Bajwa EK, Thompson BT, Christiani DC. A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline. Am J Respir Crit Care Med. 2017 May 15;195(10):1353-1361. IF=15.239

  12. Zhao S, Tang X, Miao Z, Chen Y, Cao J, Song T, You D, Zhong Y, Lin Z, Wang D, Shi Z, Tang X, Wang D, Chen S, Wang L, Gu A, Chen F, Xie L, Huang Z, Wang H, Ji Y. Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis. Redox Biol. 2022 Jun;52:102290. IF=10.787

  13. Dong J, Hu Z, Wu C, Guo H, Zhou B, Lv J, Lu D, Chen K, Shi Y, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Cao S, Qin Z, Yu D, Ma H, Jin G, Gong J, Sun C, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Wang J, Wu W, Zheng H, Zhou G, Chen H, Guan P, Peng Z, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Amos CI, Chen F, Tan W, Jin L, Wu T, Lin D, Shen H. Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet. 2012 Jul 15;44(8):895-9. IF= 35.209

  14. Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, Yang L, Dai J, Hu L, Tan W, Li Z, Deng Q, Wang J, Wu W, Jin G, Jiang Y, Yu D, Zhou G, Chen H, Guan P, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Ma H, Chen J, Chu M, Lu F, Zhang Z, Chen F, Wang X, Jin L, Lu J, Zhou B, Lu D, Wu T, Lin D, Shen H. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet. 2011 Jul 3;43(8):792-6. IF=35.532

  15. Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X, Yang P. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol. 2010 Apr;11(4):321-30. IF=17.764

  16. Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol. 2010 May 10;28(14):2445-51. IF=18.970


[2024年10月更新]