简介
颜财旺，男，博士，副教授。2019年获南京医科大学流行病与卫生统计学博士学位，2019-21年于南京医科大学基础医学院免疫学系从事博士后工作。先后入选江苏省优博和江苏省科协青年科技人才托举工程。主要致力于消化道肿瘤（胃癌）的遗传与分子机制研究。目前共发表SCI论文30余篇，其中通讯作者、第一作者（含并列）10余篇，包括Gut、Gastroenterology、Cancer Letters等国际期刊。主持国家自然科学基金青年基金、江苏省自然科学基金青年基金、中国博士后基金等科研项目5项。以主要完成人获得江苏省高等学校科学技术研究成果奖二等奖和教育部高校自然科学奖二等奖各1项，授权国家发明专利1项。
肿瘤分子与遗传流行病及机制研究
【主要研究项目】
1. 国家自然科学基金青年基金，染色体5p13.1区域遗传变异应答幽门螺杆菌感染调控PTGER4促进胃癌发生的机制研究，2021.01-2023.12，主持
2. 江苏省自然科学基金青年基金，遗传变异 rs59133000 调控幽门螺杆菌感染促进胃癌发生的免疫机制研究，2020.07-2023.0，主持
3. 中国博士后科学基金第1批特别资助—站前基金项目，遗传调控幽门螺杆菌感染促进胃癌发生的免疫机制研究，2019.10-2021.12，主持
【联系方式】
地址：南京市江宁区龙眠大道101号，南京医科大学至诚楼，邮编211166
电话：025-86868500
邮箱：caiwangyan@njmu.edu.cn
【代表性论文】
1. Zhang Y†, Gao Y†, Li F, Qi Q, Li Q, Gu Y, Zheng Z, Hu B, Wang T, Zhang E, Xu H, Liu L, Tian T, Jin G*, Yan C*.Long noncoding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming.Carcinogenesis. 2023 Nov 9:bgad080. doi: 10.1093/carcin/bgad080. Online ahead of print.
2. Ren S†, Cai P†, Liu Y, Wang T, Zhang Y, Li Q, Gu Y, Wei L, Yan C*, Jin G*. Prevalence of Helicobacter pylori infection in China: A systematic review and meta-analysis.J Gastroenterol Hepatol. 2022 Mar;37(3):464-470.
3. Gu Y†, Yan C†, Wang T, Hu B, Zhu M, Jin G*. Construction and evaluation of the functional polygenic risk score for gastric cancer in a prospective cohort of the European population.Chin Med J (Engl). 2023 Jul 20;136(14):1671-1679.
4. Zhu X†, Lv J†, Zhu M†, Yan C†, Deng B, Yu C, Guo Y, Ni J, She Q, Wang T, Wang J, Jiang Y, Chen J, Hang D, Song C, Gao X, Wu J, Dai J, Ma H, Yang L, Chen Y, Song M, Wei Q, Chen Z, Hu Z, Shen H*, Ding Y*, Li L*, Jin G*.Development, validation, and evaluation of a risk assessment tool for personalized screening of gastric cancer in Chinese populations. BMC Med. 2023 Apr 27;21(1):159.
5. Yan C†, Zhu M†, Ding Y†, Yang M†, Wang M†, Li G†, Ren C†, Huang T, Yang W, He B, Wang M, Yu F, Wang J, Zhang R, Wang T, Ni J, Chen J, Jiang Y, Dai J, Zhang E, Ma H, Wang Y, Xu D, Wang S, Chen Y, Xu Z, Zhou J, Ji G, Wang Z, Zhang Z, Hu Z, Wei Q, Shen H, Jin G*. Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations. Gut. 2020 Apr;69(4):641-651.
6. Yan C†, Zhu M†, Huang T, Yu F, Jin G*. Genome-wide association studies identified loci contribute to phenotypic variance of gastric cancer. Gut. 2018 Jul;67(7):1366-1368.
7. Yan C†, Ji Y†, Huang T†, Yu F, Gao Y, Gu Y, Qi Q, Du J, Dai J, Ma H, Jin G*. An esophageal adenocarcinoma susceptibility locus at 9q22 also confers risk to esophageal squamous cell carcinoma by regulating the function of BARX1. Cancer Lett. 2018 May 1;421:103-111.
8. Mao Y†, Yan C†, Lu Q, Zhu M, Yu F, Wang C, Dai J, Ma H, Hu Z, Shen H, Jin G*. Genetically predicted high body mass index is associated with increased gastric cancer risk. Eur J Hum Genet. 2017 Sep;25(9):1061-1066.
9. Zhu M†, Yan C†, Ren C†, Huang X†, Zhu X, Gu H, Wang M, Wang S, Gao Y, Ji Y, Miao X, Yang M, Chen J, Du J, Huang T, Jiang Y, Dai J, Ma H, Zhou J, Wang Z, Hu Z, Ji G, Zhang Z, Shen H*, Shi Y*, Jin G*. Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer. Gastroenterology. 2017 Jun;152(8):2011-2021.
10. Lin X†, Yan C†, Gao Y†, Du J, Zhu X, Yu F, Huang T, Dai J, Ma H, Jiang Y, Yin R, Hu Z, Jin G*, Xu L*, Shen H*. Genetic variants at 9p21.3 are associated with risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Sci. 2017 Feb;108(2):250-255.