刘易,博士,副教授,硕士生导师。南京医科大学公共卫生学院职业医学与环境卫生学系硕博连读,博士毕业后进入美国国立卫生院肿瘤研究所开展为期两年的博士后工作,后于南京医科大学姑苏学院流动站继续开展博士后课题。长期从事劳动卫生与环境卫生相关工作,主要围绕职业相关肺部疾病开展相关分子机制研究、人群调查及数据分析。发表相关SCI论文50余篇,h-index 22,研究发表于European Respiratory Journal,Journal of Hazardous Materials,Journal of Thoracic Oncology,Cancer Letters,JCI Insight,Cell Death & Disease等杂志上,文章总引量1600余次,第一(含共同)或通讯作者发表文章十余篇,其中一篇高被引论文。主持国家自然科学基金面上项目、青年项目、江苏省基础研究计划自然科学基金青年项目等课题。
研究方向:职业相关肺部疾病
联系方式:南京市江宁区天元东路818号南京医科大学至诚楼
主持科研项目:
(1)国家自然科学基金面上项目“矽尘诱导的衰老肺内皮细胞通过分泌Galectin-3促进矽肺进展的分子机制及干预研究”(82473601)2025/01/01-2028/12/31,49万元
(2)国家自然科学基金青年项目“铁死亡相关分子机制在矽尘所致职业肺纤维化中的研究”(82103804)2022/01/01-2024/12/31,30万元
(3)江苏省科技计划项目基础研究计划(自然科学基金)青年项目“UHRF1调控GPX4/FSP1基因DNA甲基化介导的铁死亡在矽尘所致肺纤维中分子机制及干预研究”(BK20210537)2021/07/01-2024/06/30,20万元
(4)南京医科大学姑苏学院2021年度博士后科研资助项目“职业肺纤维化肺泡损伤机制及干预研究”(GSBSHKY202102),2021/03/01-2021/12/31,30万元
近年来代表性论文(通讯/第一作者):
1. Wang T, Duan W,…, Liu Y#, Meng F#, Ni C#. Associations of combined phenotypic ageing and genetic risk with incidence of chronic respiratory diseases in the UK Biobank: a prospective cohort study. European Respiratory Journal, 2024, 63(2): 2301720.
2. Cheng D, Lian W,…, Liu Y#, Ni C#. The interplay of Cxcl10+/Mmp14+ monocytes and Ccl3+ neutrophils proactively mediates silica-induced pulmonary fibrosis. Journal of Hazardous Materials, 2024, 5:467:133713.
3. Wang Y, Cheng D,…, Liu Y#, Ni C#. IL33-mediated NPM1 promotes fibroblast-to-myofibroblast transition via ERK/AP-1 signaling in silica-induced pulmonary
fibrosis. Toxicological Sciences, 2023, 195(1):71-86.
4. Liu Y, Cheng D, Wang Y, et al. UHRF1-mediated ferroptosis promotes pulmonary fibrosis via epigenetic repression of GPX4 and FSP1 genes. Cell Death & Disease, 2022, 13(12): 1070.
5. Cheng D, Wang Y,..., Liu Y#, Ni C#. Liposomal UHRF1 siRNA shows lung fibrosis treatment potential through regulation of fibroblast activation. JCI INSIGHT, 2022, 7(22): e162831.
6. Cheng D, Li Z,..., Liu Y#, Ni C#. Targeted delivery of ZNF416 siRNA-loaded liposomes attenuates experimental pulmonary fibrosis. Journal of translational medicine, 2022, 20(1):523.
7. Liu Y, Li Y, Xu Q, et al. Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c. BBA-Molecular basis of disease. 2018, 1864, 420-431.
8. Liu Y, Luo F, Wang B, et al. STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells. Cancer letters. 2016, 370, 125-135.
9. Liu Y, Wang B, Liu X, et al. Epigenetic silencing of p21 by long non-coding RNA HOTAIR is involved in the cell cycle disorder induced by cigarette smoke extract. Toxicology Letters. 2016, 240, 60-67.
10. Liu Y, Luo F, Xu Y, et al. Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract. Toxicology and Applied Pharmacology. 2015, 282, 9-19.