尹先勇

发布者:流行病学系发布时间:2023-03-24浏览次数:8129


尹先勇,医学博士、教授、博士生导师、江苏特聘教授,入选国家重大人才工程青年项目。主要研究领域为2型糖尿病的分子与遗传流行病学,主持完成国家自然科学基金青年基金、国家自然科学基金面上项目、安徽省杰出青年基金、美国糖尿病学会(ADA)博士后研究基金等项目研究。在NatureNat Commun Am J Hum GenetSCI期刊发表第一/通讯作者(含并列)论文30篇。入围美国人类遗传学会(ASHGCharles J Epstein奖,获《美国人类遗传学杂志》(AJHG)优秀论文奖、20162024年中华医学科技奖一等奖等。主译《遗传统计学》(人民卫生出版社)。是British Journal of DermatologyJournal of Investigative DermatologyGenetics in Medicine杂志编委;兼任中华医学会皮肤性病学分会遗传学组副组长等。


研究方向:代谢性疾病的分子与遗传流行病学

联系方式:

地址:南京医科大学江宁校区至诚楼G441

邮箱:xianyongyin@njmu.edu.cn


代表性论文 (*:并列第一作者;#:并列通讯作者)

1.      Yin X#, Li J, Bose D, Okamoto J, Kwon A, Jackson AU, Fernandes Silva L, Oravilahti A, Chu X, Stringham HM, Liu L, Peng R, Xia Z, Ripatti S, Daly M, Palotie A, Scott LJ, Burant CF, Fauman EB, Wen X, Boehnke M#, Laakso M#, Morrison J#. Assessing the potential causal effects of 1,099 plasma metabolites on 2,099 binary disease endpoints. Nature Communications. 2025; 16:3039. PMID: 40155430

2.      Suzuki K*, Hatzikotoulas K*#, Southam L*, Taylor HJ*, Yin X*, Lorenz KM*, Mandla R*, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, Genter P, Gerstein HC, Giedraitis V,  González-Villalpando C, González-Villalpando ME, Gordon-Larsen P, Gross M, Guare LA, Hackinger S, Hakaste L, Han S, Hattersley AT, Herder C, Horikoshi M, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen T, Kamanu FK, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee KM, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan JA, Luk AO, Luo X, Lv J, Lynch JA, Lyssenko V, Maeda S, Mamakou V, Mansuri SR, Matsuda K, Meitinger T, Melander O, Metspalu A, Mo H, Morris AD, Moura FA, Nadler JL, Nalls MA, Nayak U, Ntalla I, Okada Y, Orozco L, Patel SR, Patil S, Pei P, Pereira MA, Peters A, Pirie FJ, Polikowsky HG, Porneala B, Prasad G, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K,  Sabanayagam C, Sandow K, Sankareswaran A, Sattar N, Schönherr S, Shahriar M, Shen B, Shi J, Shin DM, Shojima N, Smith JA, So WY, Stančáková A, Steinthorsdottir V, Stilp AM, Strauch K, Taylor KD, Thorand B, Thorsteinsdottir U, Tomlinson B, Tran TC, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Wacher-Rodarte N, Wheeler E, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamamoto K, Yoon K, Yu C, Yuan JM, Yusuf S, Zawistowski M, Zhang L, Zheng W; VA Million Veteran Program; Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Fornage M, Hanis CL, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Yokota M, Kardia SLR, Peyser PA, Pankow JS, Engert JC, Bonnefond A, Froguel P, Wilson JG, Sheu WHH, Wu JY, Hayes MG, Ma RCW, Wong TY, Mook-Kanamori DO, Tuomi T, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, Chen YDI, Rich SS, McKean-Cowdin R, Grallert H, Cheng CY, Ghanbari M, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Bowden DW, Palmer CNA, Kooner JS, Kooperberg C, Liu S, North KE, Saleheen D, Hansen T, Pedersen O, Wareham NJ, Lee J, Kim BJ, Millwood IY, Walters RG, Stefansson K, Ahlqvist E, Goodarzi MO, Mohlke KL, Langenberg C, Haiman CA, Loos RJF, Florez JC, Rader DJ, Ritchie MD, Zöllner S, Mägi R, Marston NA, Ruff CT, van Heel DA, Finer S, Denny JC, Yamauchi T, Kadowaki T, Chambers JC, Ng MCY, Sim X, Below JE, Tsao PS, Chang KM, McCarthy MI, Meigs JB, Mahajan A, Spracklen CN, Mercader JM, Boehnke M, Rotter JI, Vujkovic M, Voight BF#, Morris AP#, Zeggini E#. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. 2024 Mar;627(8003):347-357. PMID: 38374256

3.      Yin X, Bose D, Kwon A, Hanks SC, Jackson AU, Stringham HM, Welch R, Oravilahti A, Fernandes Silva L, FinnGen, Locke AE, Fuchsberger C, Service SK, Erdos MR, Bonnycastle LL, Kuusisto J, Stitziel NO, Hall IM, Morrison J, Ripatti S, Palotie A, Freimer NB, Collins FS, Mohlke KL, Scott LJ, Fauman EB, Burant C, Boehnke M#, Laakso M#, Wen X#. Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk. American Journal of Human Genetics.2022 Oct;109(10):1727-1741. PMID: 36055244.

4.      Yin X, Chan LS, Bose D, Jackson AU, VandeHaar P, Locke AE, Fuchsberger C, Stringham HM, Welch R, Yu KT, Silva LF, Service SK, Zhang DW, Hector EC, Young E, Ganel L, Das I, Abel H, Erdos MR, Bonnycastle LL, Kuusisto J, Stitziel NO, Hall I, Wagner GR, FinnGen, Kang J, Morrison J, Burant CF, Collins FS, Ripatti S, Palotie A, Freimer NB, Mohlke KL, Scott LJ, Wen XQ, Fauman EB#, Laakso M#, Boehnke M#. Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci. Nature Communications. 2022; 13:1644. PMID: 35347128.

5.      Yin X*, Kim K*, Suetsugu H*, Bang S, Wen L, Koido M, Ha E, Liu L, Sakamoto Y, Jo S, Leng R, Otomo N, Laurynenka V, Kwon Y, Sheng Y, Sugano N, Hwang Y, Li W, Mukai M, Yoon K, Cai M, Ishigaki K, Chung W, Huang H, Takahashi D, Lee S, Wang M, Karino K, Shim S, Zheng X, Miyamura T, Kang Y, Ye D, Nakamura J, Suh C, Tang Y, Motomura G, Park Y, Ding H, Kuroda T, Choe J, Li C, Niiro H, Park Y, Shen C, Miyamoto T, Ahn G, Fei W, Takeuchi T, Shin J, Li K, Kawaguchi Y, Lee Y, Wang Y, Amano K, Yang W, Tada Y, Yamaji K, Shimizu M, Atsumi T, Suzuki A, Sumida T, Okada Y, Matsuda K, Matsuo K, Kochi Y, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Kottyan L, Weirauch M, Parameswaran S, Eswar S, Salim H, Chen X, Yamamoto K, Harley J, Ohmura K, Kim T, Yang S, Yamamoto T, Kim B, Shen N, Ikegawa S, Lee H, Zhang X, Terao C#, Cui Y#, Bae S#. Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study. Annals of the Rheumatic Diseases. 2022; 81(9):1273-1280. PMID: 35609976.