朱猛

发布者:流行病学系发布时间:2017-12-14浏览次数:8103

 


朱猛,男,博士,副教授。2017年获南京医科大学流行病与卫生统计学博士学位,同年受聘于南京医科大学公共卫生学院流行病学系。2016年赴英国牛津大学从事分子流行病学研究。先后入选江苏省优博、南京医科大学优秀青年骨干教师、江苏省科协青年科技人才托举工程、江苏省高校“青蓝工程”优秀青年骨干教师。主要致力于慢性非传染性疾病(肺癌)的分子流行病学及宏观流行病学研究。目前共发表SCI论文90余篇,其中通讯作者、第一作者(含并列)30余篇,包括Lancet OncolLancet Respir MedGastroenterologyGutCancer ResearchAm J Hum Genet等国际期刊,主持国家自然科学基金青年项目、江苏省自然科学基金青年基金、科技部重点研发计划子课题、中国博士后基金等科研项目6项。

 

【研究方向】肿瘤分子与遗传流行病学

 

【主要在研项目】

1.       遗传变异调控基因表达影响肺癌易感性的分子流行病学研究,国家自然科学基金青年项目,主持,在研,22万;

2.       危险度评估指导肺癌筛查方案的前瞻性队列研究,国家重点研发计划子课题,课题骨干,结题,40万;

3.       基于GWAS的非小细胞肺癌全转录组关联与机制研究,中国博士后科学基金一等资助,主持,在研,8万;

 

【联系方式】

地址:南京市江宁区龙眠大道101号,南京医科大学致诚楼424,邮编211166

电话:025-86868291

邮箱:zhmnjmu@njmu.edu.cn

 

【代表性论文】

1Zhu M†, Wang T†, Huang Y, Zhao X, Ding Y, Zhu M, Ji M, Wang C, Dai J, Yin R, Xu L, Ma H, Wei Q, Jin G*, Hu Z*, Shen H*. Genetic Risk for Overall Cancer and the Benefit of Adherence to a Healthy Lifestyle. Cancer Res. 2021 Sep;81(17):4618-4627.

2Huang Y†, Zhu M†,  Ji M, Fan J, Xie J, Wei X, Jiang X, Xu J, Chen L, Yin R, Wang Y, Dai J, Jin G, Xu L, Hu Z, Ma H*, Shen H. Air Pollution, Genetic Factors and the Risk of Lung Cancer: A Prospective Study in the UK Biobank. Am J Respir Crit Care Med. 2021 Jul. doi: 10.1164/rccm.202011-4063OC.

3Zhu M†,  Fan J†, Zhang C†, Xu J, Yin R, Zhang E, Wang Y, Ji M, Sun Q, Dai J, Jin G, Chen L, Xu L, Hu Z, Ma H*, Shen H*. A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for lung cancer in Chinese populations. Hum Mol Genet. 2021 Aug;30(17):1666-1676.

4Jin G†, Lv J†, Yang M†, Wang M†, Zhu M†, Wang T†, Yan C, Yu C, Ding Y, Li G, Ren C, Ni J, Zhang R, Guo Y, Bian Z, Zheng Y, Zhang N, Jiang Y, Chen J, Wang Y, Xu D, Zheng H, Yang L, Chen Y, Walters R, Millwood IY, Dai J, Ma H, Chen K, Chen Z, Hu Z, Wei Q, Shen H*, Li L. Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study. Lancet Oncol. 2020 Oct; 21(10):1378-1386.

5Yan C†, Zhu M, Ding Y†, Yang M†, Wang M†, Li G†, Ren C, Huang T, Yang W, He B, Wang M, Yu F, Wang J, Zhang R, Wang T, Ni J, Chen J, Jiang Y, Dai J, Zhang E, Ma H, Wang Y, Xu D, Wang S, Chen Y, Xu Z, Zhou J, Ji G, Wang Z, Zhang Z, Hu Z, Wei Q, Shen H, Jin G*. Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.Gut 2019 Aug 5. pii: gutjnl-2019-318760.

6Dai J†, Lv J†,Zhu M, Wang Y†, Qin N†, Ma H†, He YQ, Zhang R, Tan W, Fan J, Wang T, Zheng H, Sun Q, Wang L, Huang M, Ge Z, Yu C, Guo Y, Wang TM, Wang J, Xu L, Wu W, Chen L, Bian Z, Walters R, Millwood IY, Li XZ, Wang X, Hung RJ, Christiani DC, Chen H, Wang M, Wang C, Jiang Y, Chen K, Chen Z, Jin G, Wu T, Lin D, Hu Z, Amos CI, Wu C, Wei Q, Jia WH, Li L, Shen H*. Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations. Lancet Respir Med 2019 Oct;7(10):881-891.

7Zhu M, Xu K†, Chen Y†, Gu Y†, Zhang M†, Luo F†, Liu Y, Gu W, Hu J, Xu H, Xie Z, Sun C, Li Y, Sun M, Xu X, Hsu HT, Chen H, Fu Q, Shi Y, Xu J, Ji L, Liu J, Bian L, Zhu J, Chen S, Xiao L, Li X, Jiang H, Shen M, Huang Q, Fang C, Li X, Huang G, Fan J, Jiang Z, Jiang Y, Dai J, Ma H, Zheng S, Cai Y, Dai H, Zheng X, Zhou H, Ni S, Jin G, She JX, Yu L, Polychronakos C, Hu Z*, Zhou Z*, Weng J*, Shen H*, Yang T*. Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study.Diabetes Care 2019 Aug;42(8):1414-1421.

8Zhu M, Yan C†, Ren C†, Huang X†, Zhu X, Gu H, Wang M, Wang S, Gao Y, Ji Y, Miao X, Yang M, Chen J, Du J, Huang T, Jiang Y, Dai J, Ma H, Zhou J, Wang Z, Hu Z, Ji G, Zhang Z, Shen H*, Shi Y*, Jin G*: Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer. Gastroenterology 2017; 152(8):2011-2021.

9Zhu M, Geng L†, Shen W, Wang Y, Liu J, Cheng Y, Wang C, Dai J, Jin G, Hu Z, Ma H*, Shen H: Exome-Wide Association Study Identifies Low-Frequency Coding Variants in 2p23.2 and 7p11.2 Associated with Survival of Non-Small Cell Lung Cancer Patients. J Thorac Oncol2017; 12(4):644-656.

10Jin G†, Zhu M†, Yin R, Shen W, Liu J, Sun J, Wang C, Dai J, Ma H, Wu C, Yin Z, Huang J, Higgs BW, Xu L, Yao Y, Christiani DC, Amos CI, Hu Z, Zhou B, Shi Y*, Lin D*, Shen H*: Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations. Am J Hum Genet 2015; 96(5):832-840.