张展

张展，博士，教授，博士生导师，现任公共卫生学院卫生检验与检疫学系主任。 美国国立环境卫生科学研究所（NIEHS）访问学者。现任全国公共卫生与预防医学名词编写委员会卫生检验学名词编写分委会委员、中国生物物理学会肠道菌群分会委员、江苏省预防医学会理事、江苏省分析测试学会微生物检测专业委员会委员及Gut microbes、《江苏预防医学》杂志编委。先后主持国家自然科学基金、江苏省自然科学基金等课题，以通讯或者第一作者发表SCI论文40余篇。

研究方向：肠道菌群活性组分鉴定及健康效应机制

联系方式：

地址：南京市江宁区龙眠大道101号 南京医科大学至诚楼102室

电话：025-86868401

E-mail：zhanzhang@njmu.edu.cn

主要科研项目：

1. 国家自然科学基金面上项目 (82373627), 肠道菌调控CRC-Ly6c2⁺巨噬细胞间串扰的单细胞代谢流分析方法构建及应用, 2024/01-2027/12, 主持

2. 江苏省自然科学基金面上项目（BK20251855）,  菌群CWBR-CP蛋白靶向巨噬细胞抑制结直肠癌进展的分子机制研究, 2025/09-2028/08, 主持

代表性论文：

1. Wenlong Pei†, Jing Mu†, Chao Ding†, Shanhong Ni, Yuliang Wang, Yu Xia, Wenjie Wang, Shengxuan Xu, Yifei Feng*, Lei Li*, Zhan Zhang*, A secreted protein from Hungatella hathewayi inhibits colorectal cancer by reprogramming intratumoural CD14b+ macrophages, Cell Reports, 2026, 45(9): 117988.

2. Qihang Yuan†, Yushan Sun†, Yue Zhang†, Chen Chen†, Chenye Bu, Xiaolong Hua, Lejia Sun, Yueming Sun*, Zhan Zhang*, Yifei Feng*. Intratumoral P. copri Reprograms MARCO⁺ Tumor-Associated Macrophages by Depleting Glycerophosphocholine to Drive Colorectal Cancer Progression, Cancer Res, 2026, 86(10): 2414-2428.

3. Yuhsien Lai^†, Zhuoyu Jiang^†, Xiaonan Qiu, Dan Hong, Xiuting Liu, Shenyin Liu, Xuesong Wu, Shumeng Guo, Joshua D Bloomstein, Sam T Hwang, Guozhen Tan, Liangchun Wang, Zhan Zhang*, Zhenrui Shi*. Metformin Treatment Protects Mice from Glucose-Promoted Psoriasiform Dermatitis through Enrichment of Akkermansia muciniphila with Modulation of Bacterial Tryptophan Metabolites, J Invest Dermatol, 2026, 146(3):722-733.e10.

4. Xinyi Shi^†, Li Wan^†, Shanhong Ni, Xin Wu, Jing Mu, Wenlong Pei, Zeyuan Chen, Yu Xia, Lei Li, Zhan Zhang*. Chronic Exposure to Sunset Yellow Promotes Susceptibility to Experimental Colitis in Mice through Gut Microbiota, J Agric Food Chem, 2025, 73(37): 23633-23643.

5. Yilin Ren^†, Xinyi Shi^†, Jing Mu, Shenyin Liu, Xin Qian, Wenlong Pei, Shanhong Ni, Zhengduo Zhang, Lei Li*,  Zhan Zhang*, Chronic exposure to paraben promotes nonalcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism, Food Funct, 2024,15(3) : 1562-1574.

6. Shenyin Liu, Suying Zhao, Zhiwei Cheng, Yilin Ren, Xinyi Shi, Jing Mu, Xiangyang Ge, Yuan Dai, Lei Li*, Zhan Zhang*, Akkermansia muciniphila protects against antibiotic-associated diarrhea in mice, Probiotics Antimicrob Proteins. 2024, 16(4): 1190-1204.

7. Shuang Tang^†*, Zhan Zhang^†, Robert H. Oakley, Wenling Li, Weijing He, Xiaojiang Xu, Ming Ji, Qing Xu, Liang Chen, Alicia S. Wellman, Qingguo Li, Leping Li, Jian-Liang Li, Xinxiang Li, John A. Cidlowski*, Xiaoling Li*. Intestinal epithelial glucocorticoid receptor promotes chronic inflammation-associated colorectal cancer, JCI insight, 2021,6(24):e151815.

8. Zhenyang Gu, Wenlong Pei, Yi Zhang, Jun Zhu, Lei Li, Zhan Zhang*. Akkermansia muciniphila in inflammatory bowel disease and colorectal cancer, Chin Med J (Engl), 2021, 134(23): 2841-2843.

9. Zhenyang Gu†, Wenlong Pei†, Yonghua Shen†, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li*, Zhan Zhang*. Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis, Food Funct, 2021, 12: 10184-10195.

10. Jun Zhu†, Lei Tang†, Shanlei Qiao, Lijuan Wang, Yiming Feng, Li Wang, Qian Wu, Ping Ding, Zhan Zhang*, Lei Li*. Low-dose methylmercury exposure impairs the locomotor activity of zebrafish: role of intestinal inositol metabolism, Environ Res, 2020,190:110020.

11. Lijuan Wang†, Lei Tang†, Yiming Feng†, Suying Zhao, Mei Han, Chuan Zhang, Gehui Yuan, Jun Zhu, Shuyuan Cao, Qian Wu, Lei Li*, Zhan Zhang*. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice, Gut, 2020, 69(11):1988-1997. (高被引论文)