刘起展

发布者:卫生毒理学系发布时间:2017-07-18浏览次数:9670


  刘起展,博士、博士后、二级教授,博士生导师。现任南京医科大学公共卫生学院卫生毒理学系主任、现代毒理学教育部重点实验室副主任、南京医科大学中毒研究所副所长、南京医科大学特聘教授和教学名师。美国伯明翰阿拉巴马大学(UAB)高级访问学者。

  兼任亚洲砷与健康研究联盟理事长、中国毒理学会理事、中国环境诱变剂学会理事、中国医防整合联盟理事、中国毒理学会生化与分子毒理学专业委员会副主任委员、中国环境诱变剂学会环境应激与健康损害专业委员会副主任委员、中国毒理学会毒理学教育专业委员会常务委员、中华预防医学会卫生毒理学分会常务委员、中国环境诱变剂学会活性氧生物学效应专业委员会常务委员、中国环境诱变剂学会生物标志物专业委员会常务委员、中国毒理学会免疫毒理学专业委员会委员、中国毒理学会呼吸毒理学专业委员会委员、中国毒理学会毒理学替代法与转化毒理学专业委员会委员、江苏省毒理学监事会主席、江苏省预防医学会卫生毒理与风险评估专业委员会常务委员、江苏省突发事件卫生应急专家咨询委员会委员、江苏省科学技术协会第九届委员会委员。入选爱思唯尔(Elsevier)发布2020年“中国高被引学者”榜单和我国公共卫生与预防医学领域学术影响力百强(排名第70位)。

  长期从事公共卫生与预防医学的教学和科研工作,主要开展环境毒理学、分子与遗传毒理学和地方病学等领域研究工作,近年主要探讨环境污染物致癌作用分子机制及干预措施、环境/职业有害因素所致机体和细胞损伤信号通路和表观遗传分子机制及干预。先后主持国家自然科学基金重点项目2、面上项目6项、教育部博士点基金、江苏省自然科学基金和江苏省“六大人才”高峰项目等部省级研究课题10余项;以通讯作者或第一作者发表论文100余篇,其中SCI收录论文81篇,总IF达到358.833,平均IF4.430;其中IF8.05篇、7.0<IF<8.02篇、5.0<IF<7.020篇、3.0<IF<5.041篇;被引用总次数达2212次,H指数为34;发表于JCR分区1区杂志14篇,2区杂志534篇原创性论文他引次数进入Pharmacology & ToxicologyClinical Medicine学科(ESI)前1%。获省级科技进步奖5项;以第一完成人荣获教育部高等学校科学研究优秀成果奖自然科学奖二等奖1项、江苏省科学技术奖二等奖1项、以主要参与人荣获省级科技成果奖5国家级教学成果二等奖1项和江苏省教学成果特等奖1

  参编人民卫生出版社的全国统编教材《毒理学基础》(第五、六和七版)、《毒理学实验方法与技术》(第二、三和四版);主编和副主编科学出版社的《毒理学基础-案例版》(第二版)和《毒理学综合实验教程》(第一版)及《毒理学基础笔记与复习考试指南》(第一版);参编《中华医学百科全书-毒理学》(第一版)和《现代毒理学》(第一版)以及《分子毒理学》(第一和二版)等教材和专著15部;主持国家和省级教改课题3项;指导的本科生荣获江苏省优秀毕业论文(团体)奖4次;江苏省大学生/研究生创新项目4项;培养卫生毒理学专业、劳动卫生与环境卫生学专业博士和硕士研究生、公共卫生硕士(MPH)研究生共60余人,2006年荣获南京医科大学“三育人”先进个人、2012年荣获南京医科大学“扬子江奖教金”优秀奖、2013年荣获南京医科大学教学名师称号、2015年负责的学系被评为“江苏省工人先锋号”、2016年被评为南京医科大学“十二五”期间科技工作先进个人、江苏省优秀教育工作者和江苏省第十二届科技工作者等奖项和荣誉。


研究方向:

1、环境毒理学

2、分子/遗传毒理学

3肿瘤发生发展及防控

4、环境有害因素致癌和慢性病的机制及防控


联系方式:

Emailqzliu@njmu.edu.cndrqzliu@126.com

电话:025-86868424


在研项目/主持课题:

12019年国家自然科学基金面上项目:circRNA_0026344及外泌介导自噬与上皮-成纤维细胞cross-talk在吸烟所致慢性阻塞性肺病中作用机制研究(81973085),2020.012023.12,在研,主持。

22017年国家自然科学基金重点项目:基于HIF通路与外泌体非编码RNA的砷暴露所致健康危害机制及风险评估研究(81730089),2018.012022.12,在研,主持。

32014年国家自然科学基金重点项目:燃煤污染型地方性砷中毒发病表观遗传机制及其干预研究(81430077),2015.012019.12,已结题,共同主持。

42014年国家自然科学基金面上项目:STAT3调控lnc RNA HOTAIR介导炎症诱导EMT在吸烟所致COPD和肺癌中的作用及干预研究(81473011),2015.012018.12,已结题,主持。

52012年国家自然科学基金面上项目:miR-191通过BASP1/WT1调控EMT和肿瘤干细胞特性获得在砷所致肺癌和肝癌中作用(81273114),2013.012016.12,已结题,主持。

62010年国家自然科学基金面上项目:NF-κB调控mot-2miRNA34s在低水平砷促进苯并(a)芘致肺癌中的作用(81072327),2011.012013.12,已结题,主持。

72008年国家自然科学基金面上项目:MKK4/JNK1DNA-PKcs/JNK2通路在亚砷酸钠所致细胞恶性转化和DNA损伤中的作用(30872146),2009.012011.12,已结题,主持。

82005国家自然科学基金面上项目:亚砷酸钠所致细胞hormesis的分子机制研究(30571541),2006.012008.12,已结题,主持。


代表性论文

1Peiwen Wang, Tian Xiao, Junjie Li, Dapeng Wang, Jing Sun, Cheng Cheng, Huimin Ma, Junchao Xue, Yan Li, Aihua Zhang, Qizhan Liu(刘起展)*. miR-21 in EVs from pulmonary epithelial cells promotes myofibroblast differentiation via glycolysis in arsenic-induced pulmonary fibrosis. Environmental Pollution. 2021 Apr 29; 286:117259. doi: 10.1016/j.envpol.2021.117259. Online ahead of prin. (IF8.071JCR环境科学1).

2、Wenqi Li, Lu Wu, Qian Sun, Qianlei Yang, Junchao Xue, Ming Shi, Huanwen Tang, Jingshu Zhang, Qizhan Liu(刘起展)*. MicroRNA-191 blocking the translocation of GLUT4 is involved in arseniteinduced hepatic insulin resistance through inhibiting the IRS1/AKT pathway. Ecotoxicology and Environmental Safety. 2021; 215: 112130. (IF6.291JCR环境科学与生态学1).

3、Haibo Xia, Yan Wu, ing Zhao, enqi Li, u Lu, uimin Ma, heng Cheng, ing Sun, uanyong Xiangao Bia*, Qizhan Liu(刘起展)*. The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema. Cell Biology and Toxicology. 2021 Mar 4.doi: 10.1007/s10565-021-09585-1.Online ahead of print. (IF6.691JCR医学2).

4、Junchao Xue,Tian Xiao, Shaofeng Wei, Jing Sun, Zhonglan Zou, Ming Shi, Qian Sun, Xiangyu Dai, Lu Wu, Junjie Li, Haibo Xia, Huanwen Tang, Aihua Zhang*, Qizhan Liu(刘起展)*. miR-21-regulated M2 polarization of macrophage is involved in arsenicosis-induced hepatic fibrosis through the activation of hepatic stellate cells. Journal of Cellular Physiology. 2021; 1-17. (IF6.384JCR生物学2).

5、Cheng Cheng, Yan Wu, Tian Xiao, Junchao Xue, Jing Sun, Haibo Xia, Huimin Ma, Lu Lu, Junjie Li, Aimin Shi, Tao Bian*, Qizhan Liu(刘起展)*. METTL3-mediated m6A modification of ZBTB4 mRNA is involved in the smoking-induced EMT in cancer of the lung. Molecular Therapy-Nucleic Acids. 2021; 23: 487-500. (IF8.886JCR医学1).

6、Jing Sun, Le Shi, Tian Xiao, Junchao Xue, Junjie Li, Peiwen Wang, Lu Wu, Xiangyu Dai, Xinye Ni*, Qizhan Liu(刘起展)*. microRNA-21, via the HIF-1a/VEGF signaling pathway, is involved inarsenite-induced hepatic fibrosis through aberrant cross-talk ofhepatocytes and hepatic stellate cells. Chemosphere. 2021; 266: 129177. (IF7.086JCR环境与生态学1).

7、Junjie Li, Junchao Xue, Min Ling, Jing Sun, Tian Xiao, Xiangyu Dai, Qian Sun, Cheng Cheng, Haibo Xia, Yongyue Wei, Feng Chen, Qizhan Liu(刘起展)*. MicroRNA-15b in extracellular vesicles from arsenite-treated macrophages promotes the progression of hepatocellular carcinomas by blocking the LATS1-mediated Hippo pathway. Cancer Letters. 2021; 497: 137–153. (IF8.679JCR医学1).

8、Tian Xiao, Zhonglan Zou, Junchao Xue, Binafsha Manzoor Syed, Jing Sun, Xiangyu Dai, Ming Shi, Junjie Li, Shaofeng Wei, Huanwen Tang, Aihua Zhang, Qizhan Liu(刘起展)*. LncRNA H19-mediated M2 polarization of macrophages promotes myofibroblast differentiation in pulmonary fibrosis induced by arsenic exposure. Environmental Pollution. 2021; 268: 115810. (IF8.071JCR环境科学1).

9、Huimin Ma, Lu Lu, Haibo Xia, Quanyong Xiang, Jing Sun, Junchao Xue, Tian Xiao, Cheng Cheng, Qizhan Liu(刘起展)*, and Aimin Shi *. Circ0061052 regulation of FoxC1/Snail pathway via miR-515-5p is involved in the epithelial-mesenchymal transition of epithelial cells during cigarette smoke-induced airway remodeling. Science of The Total Environment. 2020; July 23: 141181.IF7.963JCR环境科学1区).

10、Hui Xu, Min Ling, Junchao Xue, Xiangyu Dai, Qian Sun, Chao Chen, Yi Liu, Liang Zhou, Jianping Liu, Fei Luo, Qian Bian, Qizhan Liu(刘起展)*. Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epitheliumfibroblast cross-talk in COPD induced by cigarette smoking. Theranostics. 2018; 8(19): 5419-5433. (IF8.537JCR医学1).

11、Xiangyu Dai, Chao Chen, Qianlei Yang, Junchao Xue, Xiong Chen, Baofei Sun, Fei Luo, Xinlu Liu, Tian Xiao, Hui Xu, Qian Sun, Aihua Zhang, Qizhan Liu(刘起展)*. Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation. Cell Death and Disease. 2018; 9(5): 454. doi: 10.1038/s41419-018-0485-1.  (IF5.965JCR生物学2).

12、Junchao Xue, Chao Chen, Fei Luo, Xueli Pan, Hui Xu, Ping Yang, Qian Sun, Xinlu Liu, Lu Lu, Qianlei Yang, Tian Xiao, Xiangyu Dai, Peng Luo, Jiachun Lu, Aihua Zhang, Qizhan Liu(刘起展)*. CircLRP6 regulation of ZEB1 via miR-455 is involved in the epithelial-mesenchymal transition during arsenite-induced malignant transformation of human keratinocytes. Toxicological Sciences. 2018; 162(2): 450-461.  (IF4.181JCR医学2)

13、Chao Chen, Fei Luo, Xinlu Liu, Lu Lu, Hui Xu, Qianlei Yang, Junchao Xue, Le Shi, Jun Li, Aihua Zhang,Qizhan Liu(刘起展)*. NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis. Cancer Letters. 2017; 388: 21-23.  (IF6.375JCR医学2区)

14、Fei Luo, Zhonglan Zou, Xinlu Liu, Min Ling, Qingling Wang, Qi Wang, Lu Lu, Le Shi, Yonglian Liu, Qizhan Liu(刘起展)*, Aihua Zhang*. Enhanced glycolysis, regulated by HIF-1α via MCT-4, promotes inflammation in arsenite-induced carcinogenesis. Carcinogenesis. 2017; 38(6): 615-626.  (IF5.105JCR医学2).

15、Junchao Xue, Yang Liu, Fei Luo, Xiaolin LuHui Xu, Xinlu Liu, Lu Lu, Qianlei Yang, Chao Chen, Weimin Fan, Qizhan Liu(刘起展)*. Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017; 1863(3): 753–763.  (IF5.476JCR生物2).

16Bairu Wang, Yi Liu, Fei Luo, Yuan Xu, Yu Qin, Xiaolin Lu, Wenchao Xu, Le Shi, Qizhan Liu(刘起展)*, Quanyong Xiang*. Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract. Archive of Toxicology. 2016; 90: 449-461.  (IF5.901JCR医学1).

17Yi Liu, Fei Luo, Bairu Wang, Huiqiao Li, Xuan Xu, Xinlu Liu, Le Shi, Xiaolin Lu, Wenchao Xu, Lu Lu, Yu Qin, Quanyong Xiang, Qizhan Liu(刘起展)*. STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells. Cancer Letters. 2016; 370(1): 125-135.  (IF6.375JCR医学2)

18Fei Luo, Xinlu Liu, Min Ling, Lu Lu, Le Shi, Xiaolin Lu, Jun Li, Aihua Zhang,Qizhan Liu(刘起展)*. The lncRNA MALAT1, acting through HIF-1α stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2016; 1862(9): 1685–1695. (IF5.476JCR医学2).

19、Yuan Xu, Fei Luo, Yi Liu, Le Shi, Xiaolin Lu, Wenchao Xu, Qizhan Liu(刘起展)*. Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis. Archive of Toxicology. 2015; 89(7): 1071-1082.  (IF6.67JCR医学1).

20、Yue Zhao, Yuan Xu, Yuan Li, Wenchao Xu, Fei Luo, Bairu Wang, Ying Pang, Quanyong Xiang, Jianwei Zhou, Xinru Wang, Qizhan Liu(刘起展)*. NF-κB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract. Toxicology Science. 2013; 135(2): 265-276.  (IF4.328JCR医学2).

21、Rongrong Jiang, Yuan Li, Yuan Xu, Yun Zhou, Ying Pang, Lu Shen, Yue Zhao, Jiangping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Liu(刘起展)*. EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes. Archive of Toxicology. 2013; 87 (6): 991-1000. .(IF5.215JCR医学1).

22、Min Ling, Yuan Li, Yuan Xu, Ying Pang, Lu Shen, Rongrong Jiang,Yue Zhao, Xiaojun Yang, Jianping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Liu(刘起展)*. Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation. Free Radical Biology & Medicine. 2012; 52: 1508-1518.  (IF5.707JCR医学2).

23、Yuan Xu, Yuan Li, Ying Pang, Min Ling, Lu Shen, Rongrong Jiang, Yue Zhao, Jianwei Zhou, Xinru Wang, Qizhan Liu(刘起展)*. Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. Archive of Toxicology. 2012; 86: 947-959. (IF5.215JCR医学1).

24、Yuan Li, Min Ling, Yuan Xu, Shoulin Wang, Zhong Li, Jianwei Zhou, Xinru Wang, Qizhan Liu(刘起展)*. The repressive effects of NF-κB on p53 by mot-2 is involved in keratinocyte transformation induced by low levels of arsenite. Toxicologly Science. 2010; 116(1): 174-182.  (IF为5.093JCR医学2).

25、Yuan Li, Yuan Xu, Min Ling, Ye Yang, Shoulin Wang, Zhong Li, Jianwei Zhou, Xinru Wang, Qizhan Liu(刘起展)*. Mot-2-mediated crosstalk between NF-κB and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells. Environ Health Perspect. 2010; 118(7): 936-942.  (IF为6.087JCR环境科学1).


科研教学成果奖及专利:

1、2018年度高等学校科学研究优秀成果奖自然科学奖二等奖“砷暴露所致肺和皮肤损害及肿瘤的分子机制研究”, 排名第一。

2、2018年度江苏省科学技术奖二等奖“常见环境/职业有害因素所致肺损害机制及防控研究”, 排名第一。

3、2019年国家发明专利“血清外泌体miRNAs标志物在地方性砷中毒早期诊断中的应用”,排名第一。

4、2014年度国家级教学成果二等奖“公共卫生与预防医学三位一体人才培养模式创新与实践”, 排名第五。

5、2011年获江苏省高等教育教学成果一等奖公共卫生与预防医学人才培养模式的创新与实践”, 排名第四。