赵杨

赵杨，博士，教授，博士生导师。2009年获南京医科大学流行病与卫生统计学系博士学位。2010年至2012年在美国哈佛大学公共卫生学院环境流行病学系主要从事肺癌遗传数据的研究。曾在International Journal of Epidemiology, Briefings in Bioinformatics, BMC Medicine，AJRCCM，Ebiomedicine，Cell Reports，中华流行病学杂志，中国卫生统计等杂志以第一/通讯作者发表学术论文70余篇，合计发表学术论文300余篇。

研究方向包括复杂生物医学数据整合分析及因果推断方法研究、临床试验中的统计方法、真实世界研究中的统计理论与方法。先后主持国自然项目5项，国家重点研发计划课题1项。作为统计专家或独立数据监察委员会专家，参与过数十个创新药物和疫苗的临床研发工作。

现任中国卫生信息与健康大数据学会卫生统计学教育委员会主任委员，中华预防医学会生物统计学分会副主任委员，中国临床肿瘤学会(CSCO)生物统计专家委员会副主任委员，中国医药教育学会医药统计专委会副主任委员，江苏省预防医学会卫生统计学专委会主任委员。在新冠病毒肺炎疫情期间，参加了国家有关新型冠状病毒肺炎防控、新冠肺炎疫情预测预警和防控政策调整模型研究等工作。

研究方向

复杂生物医学数据整合分析及因果推断方法研究、临床试验中的统计方法、真实世界研究中的统计理论与方法

联系方式

地址：南京市江宁区龙眠大道101号南京医科大学至诚楼

电话：025-86868436

邮箱：zhaoyang@njmu.edu.cn

主持科研项目

1. 国家自然科学基金面上项目 环境混合污染物的健康效应统计分析方法研究 2024/01-2027/12  主持。

2. 科技部重点研发计划课题 孕产妇及儿童青少年大气污染暴露的多系统健康效应谱研究 2022-2025 负责人。

3. 国家自然科学基金面上项目 基于真实世界数据的个体处理效应估计方法研究 2022/01-2025/12  主持。

4. 国家自然科学基金面上项目 基于随机森林的高维生物医学数据因果推断方法研究 2019/01-2020/12  主持。

5. 国家自然科学基金面上项目 整合常见和罕见变异进行肺癌风险预测的统计方法研究 2014/01-2017/12  主持。

6. 国家自然科学基金青年基金 基于基因表达数据的风险得分函数在肿瘤诊断和预后评价中的应用研究2010/01-2012/12  主持。

代表性论文

英文

2004年

1.      You, Dongfang#; Sun, Dianjianyi; Zhao, Ziyu; Song, Mingyu; Pan, Lulu; Wu, Yaqian; Tang, Yingdan; Lu, Mengyi; Shao, Fang; Shen, Sipeng; Bai, Jianling; Yi, Honggang; Zhang, Ruyang; Wei, Yngyue; Ma, Hongxia; Xu, Hongyang; Yu, Canqing; Lv, Jun; Pei, Pei; Yang, Ling; Chen, Yiping; Chen, Zhengming; Shen, Hongbing; Chen, Feng; Zhao, Yang#; Li,Liming#;  On behalf of the China Kadoorie Biobank Collaborative Group. Spicy food consumption and risk of vascular disease: Evidence from a large-scale Chinese prospective cohort of 0.5 million people. Chinese Medical Journal ():10.1097/CM9.0000000000003177, July 19, 2024. | DOI: 10.1097/CM9.0000000000003177

2023年

1.     Yan Kong, Jiawei Zhou, Mingge Zhao, Yuhua Zhang, Tingting Tan, Zhi Xu, Zhenghua Hou, Yonggui Yuan, Liangliang Tan, Ruize Song, Yachen Shi, Haixia Feng, Wei Wu, Yang Zhao#, Zhijun Zhang#, Non-inferiority of intermittent theta burst stimulation over the left V1 vs. classical target for depression: A randomized, double-blind trial, Journal of Affective Disorders, 343,2023,343:59-70.

2.     Zhao Ziyu, Zhou Yi, Guan Jinxing, Yan Yan, Zhao Jing, Peng Zhihang, Chen Feng, Zhao Yang#,Shao Fang#. The relationship between compartment models and their stochastic counterparts: A comparative study with examples of the COVID-19 epidemic modeling[J]. Journal of Biomedical Research, In press. doi: 10.7555/JBR.37.20230137

3.     Shen S#, Li Z, Jiang Y, Duan W, Li H, Du S, Esteller M, Shen H, Hu Z, Zhao Y#, Christiani DC, Chen F#. A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer. Am J Respir Crit Care Med. 2023 May 11. doi: 10.1164/rccm.202212-2199OC. Epub ahead of print. PMID: 37167549.

4.     Wang Y, Qiu Y, Huang B, Du J, Liu L, Jiang T, Jiang Y, Lv H, Lu Q, Qin R, Tao S, Huang L, Xu X, Liu C, Ke K, Ma H, Shen H, Hu Z, Zhao Y#, Lin Y#; CNBC Study Group. Association between PM2.5 exposure and the outcomes of ART treatment: A prospective birth cohort study. Sci Total Environ. 2023 May 11:164099. doi: 10.1016/j.scitotenv.2023.164099. Epub ahead of print. PMID: 37178836.

5.     Shen S, Chen J, Li H, Jiang Y, Wei Y, Zhang R, Zhao Y#, Chen F. Large-scale integration of the non-coding RNAs with DNA methylation in human cancers. Cell Rep. 2023 Mar 28;42(3):112261. doi: 10.1016/j.celrep.2023.112261. Epub 2023 Mar 15. PMID: 36924495.

2022年

1.      Huihui Chen#, Yaqian Wu#, Jiawei Zhou, Dongfang You* &Yang Zhao*. Identifying the association rules between adverse events and concomitant medicines in clinical trial data management using random forest. Biostatistics & Epidemiology. 2022. https://doi.org/10.1080/24709360.2022.2112896

2.      Shao F, Chen Y, Xu H, Chen X, Zhou J, Wu Y, Tang Y, Wang Z, Zhang R, Lange T, Ma H, Hu Z, Shen H, Christiani DC, Chen F, Zhao Y*, You D*. Metabolic Obesity Phenotypes and Risk of Lung Cancer: A Prospective Cohort Study of 450,482 UK Biobank Participants. Nutrients. 2022; 14(16):3370. https://doi.org/10.3390/nu14163370

3.      You, D., Wang, D., Wu, Y., Chen, X., Shao, F., Wei Y., Zhang R., Lange T., Ma H., Xu H., Hu Z., Christiani, D., Shen H., Chen F. *, Zhao Y. *. Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study. BMC Med 20, 203 (2022). https://doi.org/10.1186/s12916-022-02400-6

4.      Jiaxin Zong, Yingdan Tang, Tong Wang, Inam Ullah, Ke Xu, Jing Wang, Pengsheng Chen, Zengguang Chen, Tiantian Zhu, Jun Chen, Jimin Li, Fei Wang, Lu Yang, Yuansheng Fan, Lu Shi, Xiaoxuan Gong, John W. Eikelboom, Yang Zhao* and Chunjian Li*. Impact of Insulin Receptor Substrate-1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention. J Am Heart Assoc. (2022) DOI: 10.1002/(ISSN)2047-9980

5.      Tang Y, You D, Yi H, Yang S* and Zhao Y* (2022) IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score. Front. Genet. 13:801397. doi: 10.3389/fgene.2022.801397

6.      Zhang H., Wang Z., Tang Y., Chen X., You D., Wu Y., Yu M., Chen W., Zhao Y. *, Chen X. Prediction of acute kidney injury after cardiac surgery: model development using a Chinese electronic health record dataset. J Transl Med 20, 166 (2022). https://doi.org/10.1186/s12967-022-03351-5

7.      Sun J, Lyu R, Deng L, Li Q, Zhao Y*, Zhang Y* (2022) SMetABF: A rapid algorithm for Bayesian GWAS meta-analysis with a large number of studies included. PLOS Computational Biology 18(3): e1009948. https://doi.org/10.1371/journal.pcbi.1009948

8.      Guan, Jinxing^#, Zhao, Yang*^#, Wei, Yongyue, Shen, Sipeng, You, Dongfang, Zhang, Ruyang, Lange, Theis and Chen, Feng*. Transmission dynamics model and the coronavirus disease 2019 epidemic: applications and challenges Medical Review, vol. , no. , 2022. https://doi.org/10.1515/mr-2021-0022

9.      Wu Y, Bai J, Zhang M, Shao F, Yi H, You D* and Zhao Y*(2022) Heterogeneity of Treatment Effects for Intensive Blood Pressure Therapy by Individual Components of FRS: An Unsupervised Data-Driven Subgroup Analysis in SPRINT and ACCORD. Front. Cardiovasc. Med. 9:778756. doi: 10.3389/fcvm.2022.778756

10.   Zhou J#,  Bai J#, Yue Y#, Chen X, Lange T, You D*, Zhao Y* (2022). Association of Hypokalemia Incidence and Better Treatment Response in NSCLC Patients: A Meta-Analysis and Systematic Review on Anti-EGFR Targeted Therapy Clinical Trials. Front Oncol 11: 757456.

11.   Zhang M#, Xu K#, Dai Q#, You D, Yu Z, Bao C*, Zhao Y*. A dynamic model for individualized prognosis prediction in patients with avian influenza A H7N9. Ann Transl Med 2022;10(3):149. doi: 10.21037/atm-21-4126

2021年

1.      Song R, Shi Y, Li X, Zhu J, Zhang H, Li K, Wang B, Zhang H, Yang Y, Gao L, Zhao Y* and Zhang Z* (2021) Potential of Antithrombin III as a Biomarker of Antidepressive Effect in Major Depressive Disorder. Front. Psychiatry 12:678384. doi: 10.3389/fpsyt.2021.678384

2.      Bao S#, Yue Y#, Hua Y#, Zeng T, Yang Y, Yang F, Yan X, Sun C, Yang M, Fu Z, Huang X, Li J, Wu H, Li W*, Zhao Y*, Yin Y*. Safety profile of poly (ADP-ribose) polymerase (PARP) inhibitors in cancer: a network meta-analysis of randomized controlled trials. Ann Transl Med 2021;9(15):1229. doi: 10.21037/atm-21-1883.

3.      Chen, X.#, W. Gao#, J. Li#, D. You#, Z. Yu, M. Zhang, F. Shao, Y. Wei, R. Zhang, T. Lange, Q. Wang*, F. Chen*,X. Lu*, and Y. Zhao*, A predictive paradigm for COVID-19 prognosis based on the longitudinal measure of biomarkers. Brief Bioinform, 2021.

4.      Yachen Shi#, Ruize Songa#, Zan Wanga#, Hongxing Zhang, Jianli Zhu, Yuanping Yue,Yang Zhao*, Zhijun Zhang*(2021). Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder. EBioMedicine, 2021,66,10337.

5.      Dongfang You#; Mingzhi Zhang#; Wenjing He; Danhua Wang; Yang Yu; Zhaolei Yu; Theis Lange; Sheng Yang; Yongyue Wei; Hongxia Ma; Zhibin Hu; Hongbing Shen; Feng Chen*; Yang Zhao*(2021). Association between dietary sodium, potassium intake and lung cancer risk: evidence from the prostate, lung, colorectal and ovarian cancer screening trial and the Women’s Health Initiative. Translational Lung Cancer Research, 2021, 10(1): 45-56.

6.   Xin Chen, Liangmin Wei, Hui Huang, Ruyang Zhang,LiSu, Mahmudur Rahman, Md Golam Mostofa, Quazi Qamruzzaman, Hao Yu, Yang Zhao∗, Yongyue Wei∗, David C Christiani∗and Feng Chen(2021)Assessment of individual and mixture effects of element exposure measured in umbilical cord blood on birth weight in Bangladesh Environ. Res. Commun. 3 105001.

2020年及之前

1.   Zhao Y., Wei Y.Y., Shen S.P., Zhang M.Z., Chen F. (2020). Appealing for efficient, well organized clinical trials on COVID-19. Annals of Translational Medicine. 2020. doi: 10.21037/atm-20-2429.

2.   You D.F.#, Qin N.#, Zhang M.Z., Dai J.Z., Du M.L., Wei Y.Y., Zhang R.Y., Hu Z.B., Christiani D.C., Zhao Y.*, Chen F. *. (2020) “Identification of genetic features associated with fine particulate matter (PM2.5) modulated DNA damage using improved random forest analysis”. Gene 740:144570.

3.   Han, B., K. Li, Q. Wang, L. Zhang, J. Shi, Z. Wang, Y. Cheng, J. He, Y. Shi, Y. Zhao, H. Yu, Y. Zhao, W. Chen, Y. Luo, L. Wu, X. Wang, R. Pirker, K. Nan, F. Jin, J. Dong, B. Li and Y. Sun (2018). Effect of Anlotinib as a Third-Line or Further Treatment on Overall Survival of Patients With Advanced Non-Small Cell Lung Cancer: The ALTER 0303 Phase 3 Randomized Clinical Trial. JAMA Oncol 4(11): 1569-1575.

4.   Xu Z, Yue Y, Bai J, Shen C, Yang J, Huang X, Zhao Y∗, Li Y∗. Association between oral contraceptives and risk of hemorrhagic stroke: a meta-analysis of observational studies. Arch Gynecol Obstet. 2018 May;297(5):1181-1191. doi: 10.1007/s00404-018-4723-7. Epub 2018 Feb 19. PMID: 29460112.

5.   Tang, W. #, J. Tang#, Y. Zhao#, Y. Qin, G. Jin, X. Xu, H. Zhu, H. Shen, X. Wang, Z. Hu and Y. Xia (2016). Exome-Wide Association Study Identified New Risk Loci for Hirschsprung's Disease. Mol Neurobiol.

6.   Chu, M., R. Zhang, Y. Zhao, C. Wu, H. Guo, B. Zhou, J. Lu, Y. Shi, J. Dai, G. Jin, H. Ma, J. Dong, Y. Wei, C. Wang, J. Gong, C. Sun, M. Zhu, Y. Qiu, T. Wu, Z. Hu, D. Lin, H. Shen and F. Chen (2014). A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese. Carcinogenesis 35(3): 572-577.

7.   Zhao, Y., Q. Wei, L. Hu, F. Chen, Z. Hu, R. S. Heist, L. Su, C. I. Amos, H. Shen and D. C. Christiani (2014). Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer. Cancer Epidemiol Biomarkers Prev 23(11): 2503-2511.

8.   Dai, H., Y. Zhao, C. Qian, M. Cai, R. Zhang, M. Chu, J. Dai, Z. Hu, H. Shen and F. Chen (2013). Weighted SNP set analysis in genome-wide association study. PLoS One 8(9): e75897.

9.   Zhang, R., Y. Zhao, M. Chu, A. Mehta, Y. Wei, Y. Liu, P. Xun, J. Bai, H. Yu, L. Su, H. Zhang, Z. Hu, H. Shen, F. Chen and D. C. Christiani (2013). A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure. PLoS One 8(3): e59035.

10.   Zhang, R., Y. Zhao, M. Chu, C. Wu, G. Jin, J. Dai, C. Wang, L. Hu, J. Gou, C. Qian, J. Bai, T. Wu, Z. Hu, D. Lin, H. Shen and F. Chen (2013). Pathway analysis for genome-wide association study of lung cancer in Han Chinese population. PLoS One 8(3): e57763.

11.   Zhao, Y., F. Chen, R. Zhai, X. Lin, N. Diao and D. C. Christiani (2012). Association test based on SNP set: logistic kernel machine based test vs. principal component analysis. PLoS One 7(9): e44978.

12.   Zhao, Y., F. Chen, R. Zhai, X. Lin, Z. Wang, L. Su and D. C. Christiani (2012). Correction for population stratification in random forest analysis. Int J Epidemiol 41(6): 1798-1806.

13.   Zhao, Y., H. Yu, Y. Zhu, M. Ter-Minassian, Z. Peng, H. Shen, N. Diao and F. Chen (2012). Genetic association analysis using sibship data: a multilevel model approach. PLoS One 7(2): e31134.

14.   Zhao, Y., L. Wang, H. B. Shen, Z. X. Wang, Q. Y. Wei and F. Chen (2007). Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis. J Toxicol Environ Health A 70(23): 1986-1994.

中文

1.       周佳薇, 黄丽红, 尤东方, 陈峰, 赵杨. 利用现实世界数据仿真临床试验： 目标试验的发展与应用. 中华流行病学杂志，45(2)，279-285.

2.        梁洁,李晨,黄丽红,高雪,赵杨,王彤(2023). 纵向研究中存在的时变混杂及控制方法. 中国卫生统计, 40(1), 157-160.

3.       于洋，仇沁晓，尤东方，& 赵杨. (2022). 多重并行中介分析方法的比较研究. 中华流行病学杂志，43(5)，739-746.

4.       仇沁晓, 尤东方, & 赵杨. (2021). 存在时依性混杂时的G方法. 中华疾病控制杂志, 25(06), 625-631.

5.       黄丽红, 王陵, 言方荣, 魏朝晖, 赵杨, 夏结来, & 陈峰. (2021). 新视角解读临床试验中的意向性原则. 中国临床药理学与治疗学, 26(04), 449-453.

6.       黄丽红, 王永吉, 王素珍, 赵杨, & 王彤. (2020). 倾向性评分方法及其规范化应用的统计学共识CSCO生物统计学专家委员会RWS方法学组. 中国卫生统计, 37(06), 952-958.

7.       仝娜, 易洪刚, 柏建岭, 杨晟, 陈峰, & 赵杨. (2020). 生物统计学专业的综合实验教学方式初探. 中国卫生统计, 37(06), 950-951+958.

8.       何文静, 尤东方, 张汝阳, 于浩, 陈峰, 胡志斌, & 赵杨. (2019). 利用因果森林估计异质性人群下个体的处理效应. 中华流行病学杂志(06), 707-712.

9.       王丹华, 尤东方, 黄丽红, & 赵杨. (2019). 观察性研究中针对未测量混杂干扰的敏感性分析方法. 中华流行病学杂志(11), 1470-1471-1472-1473-1474-1475.

10.     赵杨, 柏建岭, 魏永越, 易洪刚, 赵丽萍, 马红霞, . . . 陈峰. (2018). 预防医学研究生的医学统计学教学改革. 中国卫生统计, 35(05), 790-792. 

课题组成员

在读博士研究生

在读硕士研究生

已毕业研究生