肖杭

发布者:公共卫生学院发布时间:2017-07-18浏览次数:1629



肖杭博士,教授,博士生导师,任江苏省应用毒理重点实验室副主任。兼任江苏省和国家食品药品监督管理局新药审评专家,中国实验室国家认可委员会技术委员会委员,中国毒理学会理事、江苏省实验动物管理委员会副主任、专家组组长,江苏省预防医学会劳动卫生专业委员会副主任委员,江苏省实验动物协会理事长。主编教材3部,参编10余部,先后主持国家级基金项目10项,子项目6项,发表SCI论文70余篇,获得中华医学科技进步奖,江苏省科技进步一等奖,二等奖,三等奖,南京市科技进步三等奖,333工程第三层次人选。


研究方向:神经毒理及药理


联系方式:

邮箱:hxiao@njmu.edu.cn

电话:025-86868431


代表性论文:

1. Yao J, Wang J, Wu L, Lu H, Wang Z, Yu P, Xiao H, Gao R, Yu J. Perinatal exposure to bisphenol A causes a disturbance of neurotransmitter metabolic pathways in female mouse offspring: A focus on the tryptophan and dopamine pathways. Chemosphere. 2020, 254:126715.

2. Xue J, Zhang L, Xie X, Gao Y, Jiang L, Wang J, Wang Y, Gao R, Yu J, Xiao H(第一通讯), Prenatal bisphenol A exposure contributes to Tau pathology: Potential roles of CDK5/GSK3β/PP2A axis in BPA-induced neurotoxicity. Toxicology. 2020, 438:152442.

3. Chen L, Zhou L, Yu P, Fang F, Jiang L, Fei J, Xiao H, Wang J. Methamphetamine exposure upregulates the amyloid precursor protein and hyperphosphorylated tau expression: The roles of insulin signaling in SH-SY5Y cell line. The Journal of Toxicological Sciences. 2019, 44(7):493-503.

4.Chen L, Yu P, Zhang L, Zou Y, Y Zhang, Jiang L, Gao R, Xiao H(并列通讯), Qian Y, Wang J. Methamphetamine exposure induces neuropathic protein β-Amyloid expression. Toxicology in Vitro. 2019, 54:304-309.

5.Zhu J, Zang S, Chen X, Jiang L, Gu A, Cheng J, Zhang L, Wang J, Xiao H(并列通讯).Involvement of the delayed rectifier outward potassium channel Kv2.1 in methamphetamine‐induced neuronal apoptosis via the p38 mitogen‐activated protein kinase signaling pathway. Journal of Applied Toxicology. 2018,38(5):696-704.

6. Wang Z, Yu J, Yao J, Wu L, Xiao H, Wang J, Gao R. Simultaneous identification and quantification of bisphenol A and 12 bisphenol analogues in environmental samples using precolumn derivatization and ultra high performance liquid chromatography with tandem mass spectrometry. Journal of SEPARATION SCIENCE. 2018, 41(10):2269-2278.

7. Chen X, Xing J, Jiang L, Qian W, Wang Y, Sun H, Wang Y, Xiao H, Wang J, Zhang J. Involvement of calcium/calmodulin‐dependent protein kinase II in methamphetamine‐induced neural damage. Journal of Applied Toxicology. 2016, 36(11):1460-1467.

8. Wang L, Hu W, Wang J, Fang F, Cheng G, Jiang Y, Xiao H(并列通讯), Wan Q. Impact of serum uric acid, albumin and their interaction on Parkinson’s disease. Neurol Sci, 2017, 38:331-336.

9.Zhang X, Yan F, Feng J, Qian H, Cheng Z, Yang Q, Wu Y, Zhao Z, Li A, Xiao H(并列通讯). Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-κB pathway. PLoS One. 2018, 13(5):e0196897.

10.Yang J, Su J, Wan F, Yang N, Jiang H, Fang M, Xiao H, Wang J, Tang J. Tissue kallikrein protects against ischemic stroke by suppressing TLR4/NF-κB and activating Nrf2 signaling pathway in rats. Experime ntal and Therapeutic Medicine. 2017, 14(2):1163-1170.

11.Wan F, Zang S, Yu G, Xiao H, Wang J, Tang J. Ginkgolide B Suppresses Methamphetamine-Induced Microglial Activation Through TLR4-NF-κB Signaling Pathway in BV2 Cells. Neurochemical Research. 2017, 42:2881-2891.

12. Wang T, Xie C, Yu P, Fang F, Zhu J, Cheng J, Gu A, Wang J, Xiao H(并列通讯). Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity. Scientific Reports. 2017, 7:7497.

13.Zhang B, Wang L, Chen T, Hong J, Sha S, Wang J, Xiao H, Chen L. Sigma-1 receptor deficiency reduces GABAergic inhibition in the basolateral amygdala leading to LTD impairment and depressive-like behaviors. Neuropharmacology. 2017, 116:387-398.

14. Lu H, Yu J, Wang J, Wu L, Xiao H, Gao R. Simultaneous quantification of neuroactive dopamine serotonin and kynurenine pathway metabolites in gender-specific youth urine by ultra performance liquid chromatography tandem high resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2016, 122:42-51.

15. Fang F , Gao Y, Wang T , Chen D, J Liu, Qian W, Cheng J, Gao R, Wang J, Xiao H(并列通讯). Insulin signaling disruption in male mice due to perinatal bisphenol A exposure: Role of insulin signaling in the brain. Toxicology Letters. 2016, 245:59-67.

16. Li J, Wang Y, Fang F, Chen D, Gao Y, Liu J, Gao R, Wang J, Xiao H(并列通讯). Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice. Environmental Toxicology and Pharmacology. 2016, 43:7-12.

17. Lu H, Yu J, Wu L, Xing J, Wang J, Huang P, Zhang J, Xiao H, Gao R. Optimized ultra performance liquid chromatography tandem high resolution mass spectrometry method for the quantification of paraquat in plasma and urine. Journal of Chromatography B. 2016, 1027:96-102.