个人简介:
沈冲，流行病学系教授，博士研究生导师。南京医科大学附属老年医院/江苏省老年医学研究所临床流行病研究室主任。2008年毕业于北京协和医学院，曾赴卡罗林斯卡医学院（Karolinska Institutet）糖尿病研究中心和美国范德堡大学（Vanderbilt University）流行病研究中心访问学者。
江苏省“333”工程第三层次培养对象中青年学术带头人，教育部“流行病学与循证医学”课程思政教学名师和教学团队成员，“流行病学”国家级课程教学团队成员，江苏高校省级外国留学生英文授课精品教学团队成员；研究生课程《医学研究的数据管理与分析》负责人；江苏省十佳研究生导师团队成员。参编《医学研究的数据管理与分析》、《医学科研方法学》、《流行病学》（案例版）、《皮肤病流行病学》等10余部教材和专著的编写。
主要研究方向为心血管与代谢病流行病学，开展心血管病、糖尿病、精神分裂症等慢性病分子与遗传流行病学及临床转化研究，主持国自然面上项目4项，参与3项国家科技支撑/重点研发项目；合作开展糖尿病、冠心病表观遗传学和脑卒中代谢组学等多项横向合作课题研究。建立人群队列和冠心病、脑卒中专病队列超过10万人；发表论文超过300篇，其中英文论文150余篇，第一/通讯作者SCI收录论文60余篇；合计他引超过4000次；H指数29。先后参加美国心脏病联盟学术会议等国内外学术会议，在中国科协青年科学家论坛、中国慢性病大会等全国性学术会议作报告20余次。
中国老年医学学会流行病学与疾病预防分会常委，中华预防医学会心脏病预防与控制专业委员会委员、慢性病预防与控制分会委员，中国营养学会营养与慢病控制分会常务委员，江苏省老年医学学会常务理事、临床流行病学与疾病预防专委会主委，江苏省卒中学会理事、江苏省卒中学会卒中预防与控制专业委员会副主任委员，江苏省预防医学会糖尿病预防与控制专委会副主委、慢性病预防与控制专业委员会常委、流行病学专业委员会委员、心功能专委会常委，江苏省健康管理学会理事、社区健康管理专业委员会副主任委员；国家人体生物监测项目专家咨询委员会委员，南京医科大学脑卒中专病联盟委员；Human Genomics杂志副主编、《中华预防医学杂志》、《中华疾病控制杂志》、《实用老年医学杂志》编委。
研究方向：心血管疾病、慢性代谢病、精神疾病流行病学
主讲课程：《流行病学》、《医学研究的数据管理与分析》
联系方式：电子邮件：sc100@126.com
主要在研项目
1、2022/01-2025/12，国家自然科学基金面上项目，缺血性脑卒中外周血差异表达mRNA筛选、验证及基因-环境交互作用研究（82173611），52万元，在研、主持。
2、2022/10-2026/03大气污染心脑血管健康影响的巢式病例对照研究（2022YFC3702704-1），纵向，60万，研究任务负责人。
3、2019/01-2022/12，国家自然科学基金面上项目，KLFs信号通路遗传变异与高血压和脑卒中关系的分子流行病学研究（81872686），57万元、主持。
4、2018/12 -2022/12，中国中部地区主动健康云平台示范应用与评价（2018YFC2000703-1），科技部重点研发计划“主动健康和老龄化科技应对”，纵向，92万，研究任务负责人；
近3年主要贡献论文
1. Yao Fan, Qun Li, Yu Liu, Jing Miao, Ting Zhao, Jinxin Cai, Min Liu, Jun Cao, Haifeng Xu, Lai Wei, Mengxia Li, Chong Shen. Sex- and Age-Specific Prevalence of Osteopenia and Osteoporosis: Sampling Surve. JMIR Public Health and Surveillance. JMIR Public Health Surveill 2024;10:e48947) doi: 10.2196/48947
2. Jin J, Zhao X, Zhu C, Li M, Wang J, Fan Y, Liu C, Shen C, Yang R. Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease. Clin Epigenetics. 2023 Jul 28;15(1):120. doi: 10.1186/s13148-023-01533-6.
3. Bafei SEC, Zhao X, Chen C, Sun J, Zhuang Q, Lu X, Chen Y, Gu X, Liu F, Mu J, Wei L, Wei P, Yin Y, Xie H, Yang S, Shen C. Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study. Lipids Health Dis. 2023 Jul 4;22(1):95. doi: 10.1186/s12944-023-01836-w.
4. Bafei SEC, Shen C. Biomarkers selection and mathematical modeling in biological age estimation. NPJ Aging. 2023 Jul 1;9(1):13. doi: 10.1038/s41514-023-00110-8.
5. Wang L, Wang H, Yan L, Yu M, Yang J, Li J, Li J, Ning Y, Jiang H, Shi Y, Zhang W, Xiong L, Liu J, Kuang Y, Wang H, He J, Wang D, Li B, Liu Y, Shui T, Wang Y, Chen H, Sha X, Long H, Yu X, Shen C, Shen J, Yang X, Gu H, Zhang G, Wang B. Single-Dose Rifapentine in Household Contacts of Patients with Leprosy. N Engl J Med. 2023 May 18;388(20):1843-1852. doi: 10.1056/NEJMoa2205487.
6. Chen C, Gu X, Liu F, Sun C, Mu J, Jin D, Sui X, Geng D, Li Q, Jiang Y, Shen C. SNP rs3803264 polymorphisms in THSD1 and abnormally expressed mRNA are associated with hemorrhagic stroke. Front Aging Neurosci. 2023 Apr 17;15:1144364. doi: 10.3389
7. Bafei SEC, Yang S, Chen C, Gu X, Mu J, Liu F, Sun J, Zhuang Q, Wei P, Zhao X, Chen Y, Yin Y, Xie H, Shen C. Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study. Mech Ageing Dev. 2023 Apr;211:111804. doi: 10.1016/j.mad.2023.111804.
8. Tong Y, Liu F, Huang K, Li J, Yang X, Chen J, Liu X, Cao J, Chen S, Yu L, Zhao Y, Wu X, Zhao L, Li Y, Hu D, Huang J, Lu X, Shen C, Gu D. Changes in fasting blood glucose status and incidence of cardiovascular disease: The China-PAR project. J Diabetes. 2023 Feb;15(2):110-120. doi: 10.1111/1753-0407.13350.
9. Liu C, Li M, Yin Q, Fan Y, Shen C, Yang R. HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case-control study and a prospective nested case-control study. Clin Epigenetics. 2022 Dec 29;14(1):191. doi: 10.1186/s13148-022-01418-0.
10. Xie H, Zhuang Q, Mu J, Sun J, Wei P, Zhao X, Chen Y, Dong J, Chen C, Wei L, Yin Y, Yang S, Shen C. The relationship between lipid risk score and new-onset hypertension in a prospective cohort study. Front Endocrinol (Lausanne). 2022 Sep 28;13:916951. doi: 10.3389/fendo.2022.916951.
11. Chen C, Chen X, Yang S, Li Q, Ren Z, Wang L, Jiang Y, Gu X, Liu F, Mu J, Liu L, Wang Y, Li J, Yu Y, Zhang J, Shen C. Association of THBS1 genetic variants and mRNA expression with the risks of ischemic stroke and long-term death after stroke. Front Aging Neurosci. 2022 Sep 23;14:1006473. doi: 10.3389/fnagi.2022.1006473.
12. Chen X, Liu C, Yang S, Yang Y, Chen Y, Zhao X, Zhu W, Zhao Q, Ni C, Huang X, Yan W, Shen C, Gu HF. Gender Specificity and Local Socioeconomic Influence on Association of GHR fl/d3 Polymorphism With Growth and Metabolism in Children and Adolescents. Front Pediatr. 2022 Mar 23;10:546080. doi: 10.3389/fped.2022.546080.
13. Wei L, Sun J, Xie H, Zhuang Q, Wei P, Zhao X, Chen Y, Dong J, Li M, Chen C, Yang S, Shen C. Interaction Analysis of Abnormal Lipid Indices and Hypertension for Ischemic Stroke: A 10-Year Prospective Cohort Study. Front Cardiovasc Med. 2022 Mar 11;9:819274. doi: 10.3389/fcvm.2022.819274.
14. Xu X, Sun S, Liu Q, Liu X, Wu F, Shen C. Preoperative application of systemic inflammatory biomarkers combined with MR imaging features in predicting microvascular invasion of hepatocellular carcinoma. Abdom Radiol (NY). 2022 May;47(5):1806-1816. doi: 10.1007/s00261-022-03473-w.
15. Fan Y, Gao J, Li Y, Chen X, Zhang T, You W, Xue Y, Shen C. The Variants at APOA1 and APOA4 Contribute to the Susceptibility of Schizophrenia With Inhibiting mRNA Expression in Peripheral Blood Leukocytes. Front Mol Biosci. 2021. doi: 10.3389/fmolb.2021.785445.
16. Dong J, Yang S, Zhuang Q, Sun J, Wei P, Zhao X, Chen Y, Chen X, Li M, Wei L, Chen C, Fan Y, Shen C. The Associations of Lipid Profiles With Cardiovascular Diseases and Death in a 10-Year Prospective Cohort Study. Front Cardiovasc Med. 2021. doi: 10.3389/fcvm.2021.745539.
17. Cheng Y, Liu M, Liu Y, Xu H, Chen X, Zheng H, Wu X, Shen Z, Shen C. Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study. BMC Nephrol. 2021;22(1):246. doi: 10.1186/s12882-021-02452-5.
18. Liu C, Yin Q, Li M, Fan Y, Shen C, Yang R. ACTB Methylation in Blood as a Potential Marker for the Pre-clinical Detection of Stroke: A Prospective Nested Case-Control Study. Front Neurosci. 2021;15:644943. doi: 10.3389/fnins.2021.644943.
19. Tian Y, Tang W, Yang S, Zhao Y, Chen Y, Zhao X, Liu C, Chen X, Shen C. HTRA1 Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke. Int J Med Sci. 2021;18(8):1840-1847. doi: 10.7150/ijms.45856.
20. Liu C, Tang W, Zhao H, Yang S, Ren Z, Li J, Chen Y, Zhao X, Xu D, Zhao Y, Shen C. The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA. Pharmacogenomics J. 2021;21(4):458-466. doi: 10.1038/s41397-021-00222-y.
21. Yao, Yingshui, Hui Zhu, Lijun Zhu, Zhengmei Fang, Yao Fan, Chunlan Liu, Yuanrui Tian, Yan Chen, Wuzhuang Tang, Zhanyun Ren, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, and Chong Shen, A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility.Atherosclerosis, 2020. 296: p. 59-65.
22.Yang, Song, Yanping Zhao, Xiaotian Chen, Xiangfeng Lu, Yanchun Chen, Xianghai Zhao, Lijun Zhu, Zhengmei Fang, Hailong Zhao, Yingshui Yao, Chunlan Liu, and Chong Shen, The ACTB Variants and Alcohol Drinking Confer Joint Effect of Ischemic Stroke in Chinese Han Population.Journal of Atherosclerosis and Thrombosis, 2020. 27(3): p. 226-244.
23.Ren, Zhanyun, Xiaotian Chen, Wuzhuang Tang, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, Huihua Zong, Chunlan Liu, and Chong Shen, Association of DIAPH1 gene polymorphisms with ischemic stroke.Aging, 2020. 12(1): p. 416-435.