郑瑞，博士，副教授，硕士生导师，江苏省科协青年科技托举人才，现代毒理学教育部重点实验室办公室副主任。主要围绕环境有害因素致机体损伤及癌变（包括膀胱癌、儿童哮喘等）开展关键效应分子识别、毒作用机制探讨和人群风险预测评估研究。研究成果以第一作者及通讯作者身份发表于Science Advances、Advanced Science、Environment International、Cancer Research、Oncogene、Archives of Toxicology等高水平期刊。主持国家自然科学基金、中国博士后科学基金、江苏省自然科学基金等课题。现任美国细胞外囊泡协会的官方期刊Extracellular Vesicles青年编委、iMeta青年编委、江苏省环境诱变剂学会环境应激专业委员会委员、江苏省研究型医学会过敏医学专业委员会委员、江苏省预防医学会卫生监督专业委员会委员等。
研究方向：环境暴露与慢性病
联系方式：
地址：南京市江宁区龙眠大道101号南京医科大学至诚楼G236
电话：025-86868419
邮箱：ruizheng@njmu.edu.cn
主要科研项目：
（1）国家自然科学基金青年项目（82103878），2022-2024，主持
（2）中国博士后科学基金面上资助（2020M681673），2020-2022，主持
（3）江苏省高等学校自然科学面上项目（21KJB330002），2021-2023，主持
（4）江苏省博士后日常资助（2021Z140），2021-2022，主持
近年来代表性论文（通讯作者/第一作者）:
(1) Rui Zheng#, Fang Gao#, Zhenguang Mao, Yanping Xiao, Lin Yuan, Zhengkai Huang, Qiang Lv, Chao Qin, Mulong Du, Zhengdong Zhang, Meilin Wang*. LncRNA BCCE4 genetically enhances the PD-L1/PD-1 interaction in smoking-related bladder cancer by modulating miR-328-3p-USP18 signaling. Advanced Science. 2023 Oct;10(30):e2303473.
(2) Rui Zheng#*, Fang Gao#, Yanping Xiao#, Jiayuan Liang, Zhengguang Mao, Cong Gan, Hui Song, Mulong Du, Meilin Wang, Man Tian*, Zhengdong Zhang*. PM2.5-derived exosomal long noncoding RNA PAET participates in childhood asthma by enhancing DNA damage via m6A-dependent OXPHOS regulation. Environment International. 2024 Jan:183:108386.
(3) Rui Zheng#, Mulong Du#, Man Tian#, Zhaozhong Zhu, Chengcheng Wei , Haiyan Chu, Cong Gan, Jiayuan Liang, Renjie Xue, Fang Gao, Zhenguang Mao, Meilin Wang*, Zhengdong Zhang*. Fine particulate matter induces childhood asthma attacks via extracellular vesicle‐packaged let-7i-5p-mediated modulation of the MAPK signaling pathway. Advanced Science. 2022 Jan;9(3):e2102460.
(4) Rui Zheng#, Mulong Du#, Yuqiu Ge#, Fang Gao, Junyi Xin, Qiang Lv, Chao Qin, Yao Zhu, Chengyuan Gu, Mengyun Wang, Qiuyuan Zhu, Zheng Guo, Shuai Ben, Haiyan Chu, Dingwei Ye, Zhengdong Zhang*, Meilin Wang*; Identification of low-frequency variants of UGT1A3 associated with bladder cancer risk by next-generation sequencing. Oncogene. 2021 Apr;40(13):2382-2394.
(5) Mulong Du#, Rui Zheng#, Gaoxiang Ma#, Haiyan Chu#, Jiafei Lu, Shuwei Li, Junyi Xin, Na Tong, Gang Zhang, Weizhi Wang, Fulin Qiang, Weida Gong, Qinghong Zhao, Guoquan Tao, Jinfei Chen, Zhifang Jia, Jing Jiang, Guangfu Jin, Zhibin Hu, Hongbing Shen, Meilin Wang*, Zhengdong Zhang*. Remote modulation of lncRNA GCLET by risk variant at 16p13 underlying genetic susceptibility to gastric cancer. Science Advances. 2020 May 20; 6(21):eaay5525.
(6) Mulong Du#*, Junyi Xin#, Rui Zheng#...David C Christiani*. CYP2A6 activity and cigarette consumption interact in smoking-related lung cancer susceptibility. Cancer Research. 2024 Feb 15;84(4):616-625.
(7) Fang Gao#, Huiqin Li#, Zhenguang Mao, Yanping Xiao, Mulong Du, Shizhi Wang, Rui Zheng*, Zhengdong Zhang*, Meilin Wang*. An integrative approach for identification of smoking-related genes involving bladder cancer. Archives of Toxicology. 2023 Jan;97(1):177-188.
(8) Yanping Xiao#, Yang Shen#, Hui Song#, Fang Gao, Zhenguang Mao, Qiang Lv, Chao Qin, Lin Yuan, Dongmei Wu, Haiyan Chu, Meilin Wang, Mulong Du*, Rui Zheng*, Zhengdong Zhang*. AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility. Archives of Toxicology. 2024 Mar. Online ahead of print.
(9) Jialei Yang#, Zihan Ji#, Fang Gao#, Jiajin Wu, Mulong Du, Zhengdong Zhang, Lin Yuan*, Rui Zheng*, Meilin Wang*. Cigarette smoking combined with genetic variation regulates the m6A methylation of CRNKL1 and is associated with bladder cancer risk. Environmental toxicology. 2024 Jan 25. Online ahead of print.
(10)Jiajin Wu#, Fang Gao#, Rui Meng#, Huiqin Li, Zhenguang Mao, Yanping Xiao, Qiuyi Pu, Mulong Du, Zhengdong Zhang, Qiang Shao*, Rui Zheng*, Meilin Wang*. Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer. Toxicology. 2024 Mar. Online ahead of print.