尤东方，女，博士，副教授，2016年获南京医科大学统计学(生物统计学方向)学士学位；2019.5-2020.7在哈佛大学公共卫生学院进行博士联合培养，导师：Prof. David C. Christiani；2021年获流行病与卫生统计学博士学位，导师：赵杨教授。江苏省青年科技人才托举工程资助对象。主持国家自然科学基金项目1项、中国博士后科学基金项目1项、参与科技部重点研发计划1项、国家卫健委科技重⼤专项1 项。现担任《PH&C》杂志统计编委。
研究方向：
生物医学高维数据整合分析及因果推断方法研究、临床研究中的数据挖掘
联系方式：
邮箱：youdongfang@njmu.edu.cn
地址：南京医科大学龙眠大道101号至诚楼G402室
代表性论文：
You D#, Wu Y#, Lu M#, Shao F, Tang Y, Liu S, Liu L, Zhou Z, Zhang R, Shen S, Lange T, Xu H, Ma H, Yin Y, Shen H, Chen F, Christiani DC, Jin G*, Zhao Y*. A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases. Nat Commun. 2025 Mar 28;16(1):3032.
You D#, Tang Y#, Lange T, Wu Y, Lu M, Shao F, Shen S, Zhang R, Zhou H, Xu H, Yin Y, Wei Y, Chen F, Shen H, Christiani DC, Zhao Y*. Systematic analysis of relationships between serum lipids with all-cause and cause-specific mortality: Evidence from prospective cohort studies of UK Biobank and Women's Health Initiative. Clin Nutr. 2025 Apr;47:94-102.
Tong X#, You D#, Shao F, Lu M*, Zhao Y*. A Novel Adaptive Design Approach for Early-Phase Clinical Trials to Optimize Vaccine Dosage. China CDC Wkly. 2025 Apr 25;7(17):592-598.
You D#, Sun D#, Zhao Z#, Song M, Pan L, Wu Y, Tang Y, Lu M, Shao F, Shen S, Bai J, Yi H, Zhang R, Wei Y, Ma H, Xu H, Yu C, Lv J, Pei P, Yang L, Chen Y, Chen Z, Shen H, Chen F, Zhao Y*, Li L*; China Kadoorie Biobank Collaborative Group. Spicy food consumption and risk of vascular disease: Evidence from a large-scale Chinese prospective cohort of 0.5 million people. Chin Med J (Engl). 2024; 138(14):1696-1704.
You D#, Zhou Y, Yan Y, Chen F, Lu M*, Shao F*. Cost-Effectiveness Analysis of Vaccination Compliance Strategies Using a Novel Hybrid Model for Influenza Vaccination. China CDC Wkly. 2024 Dec 13;6(50):1337-1342.
You D#, Wang D#, Wu Y#, Chen X, Shao F, Wei Y, Zhang R, Lange T, Ma H, Xu H, Hu Z, Christiani DC, Shen H, Chen F*, Zhao Y*. Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study. BMC Med. 2022 Jun 6;20(1):203.
Shao F#, Chen Y#, Xu H, Chen X, Zhou J, Wu Y, Tang Y, Wang Z, Zhang R, Lange T, Ma H, Hu Z, Shen H, Christiani DC, Chen F, Zhao Y*, You D*. Metabolic Obesity Phenotypes and Risk of Lung Cancer: A Prospective Cohort Study of 450,482 UK Biobank Participants. Nutrients. 2022 Aug 17;14(16):3370.
You D#, Xu H#, Chen X, Zhou J, Wu Y, Tang Y, Wang Z, Zhao Y*, Shao F*. Association between soft drink consumption types and risk of lung cancer and all-cancer: A prospective study of PLCO data. J Biomed Res. 2022 Nov 20;36(6):390-400.
Chen H#, Wu Y#, Zhou J, You D*, Zhao Y*. Identifying the association rules between adverse events and concomitant medicines in clinical trial data management using random forest. Biostatistics & Epidemiology. 2022.
Wu Y#, Bai J#, Zhang M, Shao F, Yi H, You D*, Zhao Y*. Heterogeneity of Treatment Effects for Intensive Blood Pressure Therapy by Individual Components of FRS: An Unsupervised Data-Driven Subgroup Analysis in SPRINT and ACCORD. Front Cardiovasc Med. 2022 Feb 3;9:778756.
Zhou J#, Bai J#, Yue Y#, Chen X, Lange T, You D*, Zhao Y*. Association of Hypokalemia Incidence and Better Treatment Response in NSCLC Patients: A Meta-Analysis and Systematic Review on Anti-EGFR Targeted Therapy Clinical Trials. Front Oncol. 2022 Jan 5;11:757456.
Luan D#, You D#, Wu Y, Wu F, Xu Z, Li L, Jiao J, Zhang A, Feng H, Kong Y, Zhao Y*, Zhang Z*. Effects of interaction between single nucleotide polymorphisms and psychosocial factors on the response to antidepressant treatment in patients with major depressive disorder. J Genet Genomics. 2022 Jun;49(6):587-589.
Tang Y#, You D#, Yi H#, Yang S*, Zhao Y*. IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score. Front Genet. 2022 Mar 24;13:801397.
Chen X#, Gao W#, Li J#, You D#, Yu Z, Zhang M, Shao F, Wei Y, Zhang R, Lange T, Wang Q*, Chen F*, Lu X*, Zhao Y*. A predictive paradigm for COVID-19 prognosis based on the longitudinal measure of biomarkers. Brief Bioinform. 2021 Nov 5;22(6):bbab206.
You D#, Zhang M#, He W, Wang D, Yu Y, Yu Z, Lange T, Yang S, Wei Y, Ma H, Hu Z, Shen H, Chen F*, Zhao Y*. Association between dietary sodium, potassium intake and lung cancer risk: evidence from the prostate, lung, colorectal and ovarian cancer screening trial and the Women's Health Initiative. Transl Lung Cancer Res. 2021 Jan;10(1):45-56.
You D#, Qin N#, Zhang M, Dai J, Du M, Wei Y, Zhang R, Hu Z, Christiani DC, Zhao Y*, Chen F*. Identification of genetic features associated with fine particulate matter (PM2.5) modulated DNA damage using improved random forest analysis. Gene. 2020 May 25;740:144570.
潘璐璐,赵杨,尤东方.尿失禁与抑郁症和焦虑症发病风险的前瞻性关联研究[J].中国卫生统计, 2023, 40(1):6-8.
尤东方, 魏永越, 张汝阳, 陈峰, & 赵杨. (2018). 存在混杂时高维数据的随机森林分析. 南京医科大学学报：自然科学版, 38(7), 5.
#共同第一作者; *通讯作者.