钱旭

发布者:营养与食品卫生学系发布时间:2020-06-17浏览次数:14621


钱旭博士,教授,博士生导师,国家重大人才工程青年学者,江苏特聘教授,江苏省双创团队领军人才现任营养与食品卫生学系主任,科研共享平台主任(兼)。

2018.09至今,南京医科大学,公共卫生学院,教授

2013.12-2018.09,美国德克萨斯大学MD安德森癌症中心,神经肿瘤系,博士后

2007.09-2013.06,南京医科大学,病理学与病理生理学,博士

2003.09-2007.07,中国药科大学,生物工程,学士

 

研究方向

营养素的感应机制及在肿瘤恶性进展中的作用


社会任职

1. 中国营养学会特殊营养分会,委员

2. 江苏省营养学会常务理事,分子营养主委会主任委员(创始)

3. 江苏省药理学会中药药理专委会,副主任委员

4. 中国神经科学学会神经肿瘤分会,委员

5. 中国医师协会脑胶质瘤专业委员会基础与转化学组,委员

 

联系方式

电话:025-86868465

地址:南京市江宁区龙眠大道101

邮箱:xqianmedres@njmu.edu.cn

 

主要在研课题

2024-2027 国家自然科学基金面上项目  (82372990)

2021-2024 国家自然科学基金面上项目(82072765

2020-2022 国家自然科学基金青年项目(81902817

2019-2022 江苏省自然科学基金青年项目(BK20190650

2019-2022 江苏特聘教授支持经费

2018-2023 南京医科大学人才引进启动经费

 

代表性论著

# Co-first author, * Co-corresponding author

1.  Yin J#, Ge X#, Ding F#, He L, Song K, Shi Z, Ge Z, Zhang J, Ji J, Wang X, Zhao N, Shu C,Lin F, Wang Q, Zhou Q, Cao Y, Liu W, Ye D, Jeremy N.Rich, Wang X*, You Y*, Qian X*. Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly pathway. Sci Transl Med. 2024 Mar 20;16(739): eadg5553 

2.  Yin J#, Wang X#, Ge X#, Ding F, Shi Z, Ge Z, Huang G, Zhao N, Chen D, Zhang J, Agnihotri S, Cao Y, Ji J, Lin F, Wang Q, Zhou Q, Wang X, You Y*, Lu Z*, Qian X*. Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. Nat Commun. 2023 Sep 22;14(1):5913.

3.  Ge Z, Xu M, Ge Y, Huang G, Chen D, Ye X, Xiao Y, Zhu H, Yin R, Shen H, Ma G, Qi L, Wei G, Li D, Wei S, Zhu M, Ma H, Shi Z, Wang X, Ge X, Qian X. Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation. Cell Rep. 2023 Nov 28;42(11):113417.

4.   Zhao M#, Li Y#, Lu C#, Ding F, Xu M, Ge X, Li M, Wang Z, Yin J, Zhang J, Wang X, Ge Z, Xiao H, Xiao Y, Liu H, Liu W, Cao Y, Wang Q, You Y, Wang X, Yang K*, Shi Z*, Qian X*. PGC-1α degradation suppresses mitochondrial biogenesis to confer radiation resistance in glioma. Cancer Res. 2023;83(7):1094-1110. (Cover story)

5.   Shi Z#, Ge X#, Li M, Yin J, Wang X, Zhang J, Chen D, Li X, Wang X, Ji J, You Y*, Qian X*. Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas. Mol Cell. 2022;82(20):3919-3931.e7.

6.   Ge X#, Li M#, Yin J, Shi Z, Fu Y, Zhao N, Chen H, Meng L, Li X, Hu Z, Zhao X*, Guo H*, Qian X*. Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type 2 papillary renal cell carcinoma. Mol Cell. 2022;82(7):1249-1260.e7.

7.   Li X#,*, Qian X#, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, DePinho RA, Lu Z*. Programmable base editing of mutated TERT promoter inhibits brain tumor growth. Nat Cell Biol. 2020;22(3):282-288.

8.   Qian X#,*, Li X#, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z*. KDM3A senses oxygen availability to regulate PGC-1a-mediated mitochondrial biogenesis. Mol Cell.2019;76(6):885-895.e7.

9.   Qian X#,*, Li X#, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L, Zheng Y, Zhao D, Zhang C, Lorenzi PL, You Y, Jiang BH, Jiang T, Li H, Lu Z*. PTEN suppresses glycolysis by dephosphorylating and inhibiting autophosphorylated PGK1. Mol Cell.2019;76(3):516-527.e7.

10. Qian X#, Li X#, Tan L, Lee JH, Xia Y, Cai Q, Zheng Y, Wang H, Lorenzi PL, Lu Z. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discov.2018;8(1):94-107.

11. Li X#, Qian X#, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, Lu Z. Nuclear PGK1 alleviates local ADP-dependent inhibition of CDC7 to promote DNA replication. Mol Cell.2018;72(4):650-660.e8.

12. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell. 2017;65(5):917-931.e6.

全部论文请见:https://www.ncbi.nlm.nih.gov/myncbi/14WtmP_E7ibc2B/bibliography/public/