沈思鹏,医学博士,博士后,副教授,硕士生导师。2014年获南京医科大学预防医学学士学位。2017.3-2019.3在哈佛大学公共卫生学院博士联合培养,导师:Prof. David C. Christiani。2019年获流行病与卫生统计学博士学位,导师:陈峰教授。担任江苏省卫生统计专业委员会青年委员,江苏省整合医学会胃癌专委会副主任委员。曾获得江苏省科协青年科技人才托举工程、江苏创新创业优秀博士后、江苏省医学科技奖等荣誉。
研究方向:
1、超大人群队列组学数据整合分析的策略与方法研究
2、临床研究中大数据的深度挖掘
3、传染病预警预测系统研究与开发
研究领域:
遗传统计学(Statistical genetics),计算生物学(Computational biology)
科研服务:
1. Editorial Board, Scientific Reports
2. Advisory Board, Genetics section, Heliyon (Cell Press)
3. Military Medical Research 科学编辑(2021-2024),优秀科学编辑(2023年)
4. Frontiers in Genetics 客座主编,Topic: Integrative Approaches to Analyze Cancer Based on Multi-Omics
科研项目:
1. 国自然基金面上项目,基于超大人群全基因组测序的肺癌胚系突变关联整合方法研究,82373685,2024.1-2027.12,主持。
2. 国自然基金青年项目,基于遗传变异的跨组学整合统计方法及其在肺癌风险中的研究,82103946,2022.1-2024.12,主持。
3. 常州公共卫生高等研究院开放课题,常州市肠道传染病流行趋势和监测预警研究,2023.12-2025.11,主持
联系方式:
地址:南京医科大学龙眠大道101号至诚楼G406室
10篇组学领域代表性论文:
1. Shen S*#; Chen J#; Li H; Jiang Y; Wei Y; Zhang R; Zhao Y*; Chen F. Large-scale integration of the non-coding RNAs with DNA methylation in human cancers. Cell Reports. 2023;42(3):112261.(一作兼通讯,中科院一区)
2. Shen S, Li Z, Jiang Y, Duan W, Li H, Du S, Esteller M, Shen H, Hu Z, Zhao Y, Christiani DC, Chen F. A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer. Am J Respir Crit Care Med. In Press.(中科院一区)
3. Shen S#, Zhang R#, Jiang Y, Li Y, Lin L, Liu Z, Zhao Y, Shen H, Hu Z, Wei Y*, Chen F*. Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types. Molecular Cancer. 2021 Apr 13;20(1):67. (中科院一区)
4. Shen S#, Wei Y#, Li Y, Duan W, Dong X, Lin L, You D, Tardon A, Chen C, Field J, Hung R, Liu G, Zhu D, Amos C, Su L, Zhao Y, Hu Z, Shen H, Zhang R*, Chen F*, Christiani DC*. A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival. npj Precision Oncology. 2021 May 17;5(1):39. (中科院一区)
5. Shen S#, Wang G#, Zhang R, Zhao Y, Wei Y, Chen F*. Development and validation of an immune gene-set based prognostic signature in ovarian cancer. EBioMedicine. 2019;40:318-26. (中科院一区,ESI高被引)
6. Jiang Y, Li H, Li Z, Du S, Zhang R, Zhao Y, Christiani DC, Shen S*, Chen F*. A cross-trait study of lung cancer and its related respiratory diseases based on large-scale exome sequencing population. Transl Lung Cancer Res. 2024;13(3):512-25.(中科院二区)
7. Li H#, Du S#, Dai J, Jiang Y, Li Z, Fan Q, Zhang Y, You D, Zhang R, Zhao Y, Christiani DC, Shen S*, Chen F*. Proteome-wide Mendelian randomization identifies causal plasma proteins in lung cancer. iScience. 2024;27(2):108985.(中科院二区)
8. Zhang R#, Shen S#, Wei Y#, Zhu Y, Li Y, Chen J, Guan J, Pan Z, Wang Y, Zhu M, Xie J, Xiao X, Zhu D, Li Y, Albanes D, Landi MT, Caporaso N, Lam S, Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeboller H, Wichmann HE, Rennert G, Arnold S, Brennan P, McKay J, Field JK, Shete SS, Le Marchand L, Liu G, Andrew A, Kiemeney LA, Zienolddiny-Narui S, Behndig A, Johansson M, Cox A, Lazarus P, Schabath MB, Aldrich MC, Dai J, Ma H, Zhao Y, Hu Z, Hung RJ, Amos CI, Shen H, Chen F*, Christiani DC. A large-scale genome-wide gene-gene interaction study of lung cancer susceptibility in Europeans with a trans-ethnic validation in Asians. J Thorac Oncol. 2022 Aug;17(8):974-990. (中科院一区)
9. Wang F#, Tan F#, Shen S#, Wu Z#, Cao W#, Yu Y, Dong X, Xia C, Tang W, Xu Y, Qin C, Zhu M, Li J, Yang Z, Zheng Y, Luo Z, Zhao L, Li J, Ren J, Shi J, Huang Y, Wu N, Shen H, Chen W, Li N*, He J. A Risk-Stratified Approach for Never- and Ever-Smokers in Lung Cancer Screening: A Prospective Cohort Study in China. Am J Respir Crit Care Med. 2023 Jan 1;207(1):77-88. (中科院一区)
10. Chen J#, Shen S#, Li Y#, Fan J#, Xiong S, Xu J, Zhu C, Lin L, Dong X, Duan W, Zhao Y, Qian X, Liu Z, Wei Y, Christiani DC*, Zhang R*, Chen F*. APOLLO: An accurate and independently validated prediction model of lower-grade gliomas overall survival and a comparative study of model performance. EBioMedicine. 2022;79:104007.(中科院一区)
#: 共同第一作者; *: 通讯作者.