陈超

发布者:职业医学与环境卫生学系发布时间:2019-06-13浏览次数:2772





陈超,博士,毕业于中国药科大学药物化学专业。2018-2021年,进入公共卫生与预防医学流动站从事博士后工作。2021年担任公共卫生学院职业医学与环境卫生学学系讲师。主要研究方向为QSAR与环境卫生。主要从事环境污染物相关的人工智能模型、结构机制以及混合物风险评估研究。

 

主持科研项目

1. 国自然青年项目,基于Compound-I计算模型的CYP酶代谢活化多环芳烃的结构机制研究。2022-2024

2. 国家环境保护农药环境评价与污染控制重点实验室开放项目,基于机器学习人工智能构建农药毒性预测及警示结构识别系统。2022-2023

3. 江苏省优势学科创新项目,基于 CYP1A1 代谢活化的 PM2.5 中关键 PAH 类毒性组分的识别与评价。2019-2020

 

  

近年论文发表

1. Chen, Chao#, Huang#, Zhengliang, Zou, Xuyan, Li, Sheng, Zhang, Di, Wang, Shoulin, Prediction of molecular-specific mutagenic alerts and related mechanisms of chemicals by a convolutional neural network (CNN) model based on SMILES split, Sci Total Environ, 2024, 917: 170435.

2. Chen, Chao#, Zhang, Di#, Yuan, Anjie, Shen, Jiemiao, Wang, Li, Wang, Shoulin, A novel approach to predict the comprehensive EROD potency: Mechanism-based curve fitting of CYP1A1 activity by PAHs, Science of The Total Environment, 2022, 843: 157052.

3. Chao Chen#, Yue Min#,Xuxu Lia, Dongyin Chen, Jiemiao Shen, Di Zhang, Hong Sun, Qian Bian, Haoliang Yuan, Shou-Lin Wang*, Mutagenicity risk prediction of PAH and derivative mixtures by in silico simulations oriented from CYP compound I-mediated metabolic activation, Sci Total Environ, 2021, 787: 147596.

4. Chao Chen#, Jiemiao Shen#, Liu Yang, Wen Zhang, Rong Xia, Fei Huan, Xing Gong, Li Wang, Chao Wang, Hao-Liang Yuan, Shou-Lin Wang*, Identification of structural properties influencing the metabolism of polycyclic aromatic hydrocarbons by cytochrome P450 1A1, Sci Total Environ, 2021, 758: 143997.

5. Chao Chen#, Ren-Hua Sun#, Yan Sun, Xuan Chen, Fei Li, Xiao-An Wen, Hao-Liang Yuan*, Dong-Yin Chen*, Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors, Bioorg Med Chem Lett, 2020, 30(2): 126824.

 

联系方式chenchao1990@njmu.edu.cn