张二宝，男，博士，副研究员。主要从事肿瘤发生发展相关基础研究，近年来第一和通讯作者在Genome Biology、Cancer Research、Nucleic Acids Research、Oncogene等国际期刊发表多篇研究论文，并担任Advanced Science、Oncogene等期刊审稿专家。作为项目负责人，主持完成国家自然科学青年基金等多个科研项目，现主持在研国家自然科学基金面上项目，江苏省自然科学基金面上项目等。研究成果以主要完成人获教育部自然科学奖和中国抗癌协会科技奖。作为指导老师获全国大学生“挑战杯”竞赛江苏省特等奖。
研究方向：肿瘤发生相关基础研究。
联系方式：
地址：南京市江宁区龙眠大道101号，南京医科大学至诚楼572室，邮编211166
电话：15852930516
邮箱：erbaozhang@njmu.edu.cn
主要在研项目：
国家自然科学基金面上项目，82172992，2022/01 -2025/12, 在研，主持。
江苏省自然科学基金面上项目，BK20211253，2021/07 -2024/06, 在研，主持。
主要论文：
(1) EB Zhang#*, XZ He#, CG Zhang#, J Su#, XY Lu, XX Si, JF Chen, DD Yin*, L Han*, W De*. A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1. Genome Biology, 2018 Oct 4;19(1):154.（第一作者兼通讯作者）
(2) QQ Zhu#, CG Zhang#, TY Qu#, XY Lu#, XZ He, W Li, DD Yin*, L Han*, RH Guo*, EBZhang*. MNX1-AS1 promotes phase separation of IGF2BP1 to drive c-Myc-mediated cell cycle progression and proliferation in lung cancer. Cancer Research,2022 Dec 2;82(23):4340-4358.（通讯作者）
(3) EB Zhang#, L Han#, DD Yin#, XZ He, LZ Hong, XX Si, MT Qiu, TP Xu, W De*, L Xu*, YQ Shu*, JF Chen*. H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma. Nucleic Acids Research, 2017 Apr 7;45(6):3086-3101.（第一作者）
(4)C Zhang#, Qi Sun#, X Zhang#, N Qin, ZN Pu, YY Gu, CW Yan, M Zhu, JC Dai, C Wang, N Li, GF Jin, HX Ma, ZB Hu, EB Zhang*, FW Tan*, HB Shen*. Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma.Cancer Communications, 2022 Jul;42(7):609-626.（并列通讯作者）
(5) XY Lu#, J Wang#, W Wang#, CF Lu#, TY Qu, XZ He, XY Liu, RH Guo*, EB Zhang*. Copy number amplification and SP1-activated lncRNA MELTF-AS1 regulates tumorigenesis by driving phase separation of YBX1 to activate ANXA8 in non-small cell lung cancer. Oncogene, 2022Jun;41(23):3222-3238.（通讯作者）
(6) DD Yin#, XY Lu#, J Su#, XZ He, W De, JS Yang*, W Li*, L Han*, EB Zhang*. Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non-small cell lung cancer cell proliferation by epigenetically repressing p21 expression. Molecular Cancer, 2018 May 24;17(1):92.（通讯作者）
(7) YN Cui#, Jun Li#, PP Zhang#, DD Yin#, W Wang*, EB Zhang*, RH Guo*. B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma.Journal of Experimental & Clinical Cancer Research, 2023 Jun 12;42(1):146.（并列通讯作者）
(8) JL Dai#, TY Qu#, DD Yin#, YN Cui#, C Zhang, EB Zhang*, RH Guo*. LncRNA LINC00969 promotes acquired gefitinib resistance by epigenetically suppressing of NLRP3 at transcriptional and posttranscriptional levels to inhibit pyroptosis in lung cancer. Cell Death & Disease, 2023 May 8;14(5):312.（并列通讯作者）
(9) TW Xu#, S Yan#, LH Jiang#, SX Yu#, TY Lei, DL Yang, BB Lu, CC Wei, EB Zhang*, ZX Wang*. Gene Amplification-Driven Long Noncoding RNA SNHG17 Regulates Cell Proliferation and Migration in Human Non-Small-Cell Lung Cancer.Molecular Therapy-Nucleic Acids, 2019 Sep 6;17:405-413.（并列通讯作者）
(10) Q Wang#, W Zhang#, DD Yin#, ZB Tang, EB Zhang*, WB Wu*. Gene amplification-driven lncRNA SNHG6 promotes tumorigenesis via epigenetically suppressing p27 expression and regulating cell cycle in non–small cell lung cancer. Cell Death Discovery, 2022Dec 9;8(1):485.（并列通讯作者）