王玉邦

发布者:卫生毒理学系发布时间:2017-07-18浏览次数:2824


王玉邦,男,博士,教授。主要从事内分泌毒理学研究和安全性评价工作。主持国家自然科学基金、国家科技支撑计划子课题、省自然科学基金、省教育厅基金各1项。参与各类课题多项。发表论文60余篇,其中SCI论文31篇。现任中国毒理学会毒理学家资格认证工作委员会委员、江苏省毒理学会副秘书长、江苏省实验室资质认定评审员等。


研究方向:生殖内分泌毒理学


代表性论文

1. Zhang C, Gong P, Ye Y, Zhang L, Chen M, Hu Y, Gu A, Chen S, Wang Y. NF-κB-vimentin is involved in steroidogenesis stimulated by di-n-butyl phthalate in prepubertal female rats. Toxicol Res (Camb). 2018, 18(7):826-833.

2. Gong P, Chen S, Zhang L, Hu Y, Gu A, Zhang J, Wang Y. RhoG-ELMO1-RAC1 is involved in phagocytosis suppressed by mono-butyl phthalate in TM4 cells. Environ Sci Pollut Res Int. 2018, 25(35):35440-35450.

3. Zhang C, Gong P, Ye Y, Zhang L, Chen M, Hu Y, Gu A, Chen S, Wang Y. NF-κB-vimentin is involved in steroidogenesis stimulated by mono-butyl phthalate in primary cultured ovarian granulosa cells. Toxicol in Vitro, 2017,45:25-30.

4. Lu H, Zhang C, Hu Y, Qin H, Gu A, Li Y, Zhang L, Li Z, Wang Y. miRNA-200c mediates mono-butyl phthalate-disrupted steroidogenesis by targeting vimentin in Leydig tumor cells and murine adrenocortical tumor cells[J]. Toxicol Lett, 2016,241:95-102.

5. Li Y, Hu Y, Dong C, Lu H, Zhang C, Hu Q, Li S, Qin H, Li Z, Wang Y. Vimentin-Mediated Steroidogenesis Induced by Phthalate Esters: Involvement of DNA Demethylation and Nuclear Factor κB. PLoS One. 2016, 11(1):e0146138.

6. Wang Y, Qin H, Zhang C, Huan F, Yan T, Zhang L. The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo. Molecules. 2016, 21, 46.

7. Xu C, Liu Q, Huan F, Qu J, Liu W, Gu A, Wang Y, Jiang Z. Changes in Gut Microbiota May Be Early Signs of Liver Toxicity Induced by Epoxiconazole in Rats. Chemotherapy. 2015, 60(2):135-142.(并列通讯作者)

8. Hu Y, Dong C, Chen M, Chen Y, Gu A, Xia Y, Sun H, Li Z, Wang Y. Effects of monobutyl phthalate on steroidogenesis through steroidogenic acute regulatory protein regulated by transcription factors in mouse Leydig tumor cells. J Endocrinol Invest. 2015, 38(8):875-884.

9. Shen L, Chu Z, Yang J, Wang Y. The risk of menstrual abnormalities after preconceptional use of folic acid or a folic acid-containing multivitamin in Chinese women. Ecol Food Nutr. 2015, 11:1-8.

10. Hu Y, Dong C, Chen M, Lu J, Han X, Qiu L, Chen Y, Qin J, Li X, Gu A, Xia Y, Sun H, Li Z, Wang Y. Low-dose monobutyl phthalate stimulates steroidogenesis through steroidogenic acute regulatory protein regulated by SF-1, GATA-4 and C/EBP-beta in mouse Leydig tumor cells. Reprod Biol Endocrin.2013, 11:72.

11. Bao A, Man X, Guo X, Dong H, Wang F, Sun H, Wang Y, Zhou Z and Sha J. Effects of di-n-butyl phthalate on male rat reproduction following pubertal exposure. Asian J Androl. 2011, 13(5): 702-709. (并列通讯作者)

12.Yuan C, Wang C, Gao SQ, Kong TT, Chen L, Li XF, Song L, Wang YB. Effects of permethrin, cypermethrin and 3-phenoxybenzoic acid on rat sperm motility in vitro evaluated with computer-assisted sperm analysis. Toxicol In Vitro. 2010, 24(2): 382 - 386.

13.Wang Y, Song L, Cui L, Hong X, Zhang Z, Wang X. Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenicacute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). J Toxicol Environ Health A. 2007, 70(11):947-55.

14.Cui L, Wang Y, Shi Y, Zhang Z, Xia Y, Sun H, Wang S, Chen J, Zhang W, Lu Q, Song L, Wei Q, Zhang R, Wang X. Over expression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer. Proteomics. 2007, 7: 4192-4202.  (并列第一)

15.Wang YB, Song L, Hong X, Cui LB, Zhang ZD, Xiao H, X, Zhou JW, Wang XR. Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse leydig tumor cells (MLTC-1). Chem-Biol Interact. 2006, 164: 15-24.