Research Interest
Gut Microbiota and Metabolism
Inflammatory Bowel Disease and Colorectal Cancer
Education
National Institute of Environmental Health Sciences, Gene-Environment Interaction in Disease and Aging, visiting scholar (2018-2019)
Nanjing Medical University, Toxicology, Ph.D. (2009-2014)
Nanjing Medical University, Preventive Medicine, B.S. (2004-2009)
Ongoing Research Projects
● PI, Study on the role and mechanism of cytochrome P450 1A1-mediated bioactivation in elemicin-induced abnormal lipid metabolism, Jiangsu Provincial Department of Science and Technology, BK20201354
● PI, Study on the role and molecular mechanisms of FBH1 in caffeic acid- induced the amelioration of enteric dysbacteriosis-inflammatory response, NSFC, 81502801
Selected Papers
1. Shuang Tang†*, Zhan Zhang†, Robert H. Oakley, Wenling Li, Weijing He, Xiaojiang Xu, Ming Ji, Qing Xu, Liang Chen, Alicia S. Wellman, Qingguo Li, Leping Li, Jian-Liang Li, Xinxiang Li, John A. Cidlowski*, Xiaoling Li*. Intestinal epithelial glucocorticoid receptor promotes chronic inflammation-associated colorectal cancer, JCI insight, 2021, 6(24): e151815.
2. Zhenyang Gu, Wenlong Pei, Yi Zhang, Jun Zhu, Lei Li, Zhan Zhang*. Akkermansia muciniphila in inflammatory bowel disease and colorectal cancer, Chin Med J (Engl), 2021, 134(23): 2841-2843.
3. Zhenyang Gu†, Wenlong Pei†, Yonghua Shen†, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li*, Zhan Zhang*. Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis, Food Funct, 2021, 12: 10184-10195.
4. Jun Zhu†, Lei Tang†, Shanlei Qiao, Lijuan Wang, Yiming Feng, Li Wang, Qian Wu, Ping Ding, Zhan Zhang*, Lei Li*. Low-dose methylmercury exposure impairs the locomotor activity of zebrafish: role of intestinal inositol metabolism, Environ Res, 2020, 190: 110020.
5. Lijuan Wang†, Lei Tang†, Yiming Feng†, Suying Zhao, Mei Han, Chuan Zhang, Gehui Yuan, Jun Zhu, Shuyuan Cao, Qian Wu, Lei Li*, Zhan Zhang*. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice, Gut, 2020, 69(11): 1988-1997.
