Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University
Associate Professor of Nutrition and Food Hygiene
Member of Biomarker Professional Committee of Chinese Society of Environmental Mutagens
Member of China Medical Prevention Integration Alliance
Email: liyuan@njmu.edu.cn
Research Interest
Cell Signaling and Targeted Cancer Intervention.
Functions and Mechanisms of Health Foods, and Food Toxicology
Education
Ph.D in Toxicology, 2013, Nanjing Medical University, Nanjing, China
M.Sc in Toxicology, 2010, Nanjing Medical University, Nanjing, China
B.Sc in Medicine, 2007, Nanjing Medical University, Nanjing, China
Honors and Awards
2017, Outstanding Researcher in Nutrition of China
2019, The “Qing Lan” Project Funded by Jiangsu Province
Ongoing Research Projects
l PI, Targeting drug-resistant hepatocellular carcinoma via oxidative/phosphorylation regulatory protein 14-3-3 eta by small molecule compounds and its mechanistic study, 81961160708.
Selected papers
1. Jian Shen, Fei Jiang, Ye Yang, Guangming Huang, Fuxing Pu, Qinqiang Liu, Lijun Chen, Liang Ju, Ming Lu, Fei Zhou, Chi Zhang, Xiagang Luo, Xiaojun Yang, Chengyu Jiao, Xiangcheng Li, Zhong Li, Yuan Li (Corresponding author), Jianping Zhang. 14-3-3η is a novel growth-promoting and angiogenic factor in hepatocellular carcinoma. J Hepatol. 2016, 65: 953-962.
2. Yongxin Qiu, Yi Dai, Chi Zhang, Ye Yang, Ming Jin, Wenqi Shan, Jian Shen, Ming Lu, Zhaoyang Tang, Liang Ju, Yuting Wang, Ruonan Jiao, Yunwei Xia, Guangming Huang, Lihua Yang, Yuan Li (Corresponding author), Jianping Zhang, Vincent Kam Wai Wong and Zhihong Jiang. Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3η/NF-κB feedback loop. J Exp Clin Cancer Res. 2018, 37: 321.
3. Yongxin Qiu, Wenqi Shan, Ye Yang, Ming Jin, Yi Dai, Hanyu Yang, Ruonan Jiao, Yunwei Xia, Qinqiang Liu, Liang Ju, Guangming Huang, Jianping Zhang, Lihua Yang, Lei Li and Yuan Li (Corresponding author). Reversal of sorafenib resistance in hepatocellular carcinoma: epigenetically regulated disruption of 14-3-3η/hypoxiainducible factor-1α. Cell Death Discov, 2019, 5: 120.
4. Ming Ji, Ye Yang, Yi Da, Rong Cai, Liunan Wu, Yuwen Jiao, Zhan Zhang, Haojun Yang, Yan Zhou, Liming Tang, Lei Li, Yuan Li (Corresponding author). 27-Hydroxycholesterol is a specific factor in the neoplastic microenvironment of HCC that causes MDR via GRP75 regulation of the redox balance and metabolic reprogramming. Cell Biol Toxicol. 2022, 38(2): 311-324.
5. Zhenxiong Gao, Tingting Fan, Linbo Chen, Mengchu Yang, Vincent Kam Wai Wong, Dawei Chen, Zijian Liu, Yaoyao Zhou, Weibin Wu, Zixuan Qiu, Cunlong Zhang, Yuan Li (Corresponding author), Yuyang Jiang. Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein. Eur J Med Chem. 2022, 238: 114402.
