Chen Feng

发布者：公共卫生学院发布时间：2022-10-25浏览次数：644

陈峰,　博士教授

Feng Chen, Ph.D

fengchen@njmu.edu.cn


Professor of  Biostatistics , School of  Public Health , Nanjing Medical University

Chairperson , China Association of Biostatistics(CABS)

Chairperson , China Clinical Trial Statistics (CCTS) working group


Research Interest

The methods of  high dimensional  data, non-independent data

Statistics  and regulatory science in clinical trials



Education

  • Visiting  Scientist. Department of  Environmental Health , Harvard School of  Public Health. 2008.4~2012.3

  • Visiting Scholar. Department of  Statistics , Institute of  Education, University of  London. London, 1996.4~1996.7

  • Ph.D  in  Biostatistics , 1994 , West China University of  Medical  Science. Chengdu, Sichuan, PR China

  • M.Sc  in  Biostatistics , 1989 , Shanghai Second Medical University . Shanghai, PR China

  • B.Sc  in  Mathematics ,1983 , Sun Yat-Sen University , Guangzhou , PR China



Ongoing Research Projects (PI)

  • Development and validation of lung cancer risk prediction models in Sino-European large-scale prospective cohorts using Bayesian causal network. Projects of International Cooperation and Exchanges NSFC

  • Study on the epidemic trend of 2019-nCoV infection. Gates Foundation INV-006371


Completed Research Projects (PI)


  • Study on the epidemic trend of 2019-nCoV infection: a cross-regionalrandom dynamic model based on big-data. NSFC82041024

  • Metal Exposures and Adverse Birth Outcomes: A multinational Birth CohortStudy. State’s Key Project of Research and Development Program2016YFE0204900 

  • Study on statistical methods for biomedical big data integration and riskassessment of common cancers. NSFCKeyProgram81530088

  • Onstatistical methods for gene-gene and gene-environment interaction analysis of GWAS,NSFC 81473070

  • Strategies of  Dimensionality Reduction and Statistical Methods for GWAS Data,NSFC 81072389

  • Study and assessment on statistical methods for non-traditional case-control design. NSFC 30571619

  • Power and sample size estimation for non-independent experiment design inmedical research. NSFC for Youth scholars. 39500127

  • Onstatistical methods for high-dimensional biological data. Key Project of  Natural Science Foundation of  Jiangsu, 10KJA33034 



Selected Papers(Corresponding Author)

  1. YouD, Wang D, Wu Y, Chen X, Shao F, Wei Y, Zhang R, Lange T, Ma H, XuH, Hu Z, Christiani DC, Shen H, Chen F,Zhao Y. Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study. BMCMed.2022 Jun 6;20(1):203. IF=11.15

  2. WeiL, Huang H, Chen X, Wang X, Zhang R, Su L, Duan W, Rahman M, GolamMostofa M, Qamruzzaman Q, Shen H, Hu Z, Wei Y, Christiani DC, Chen F.Umbilical cord serum elementomics of 52 trace elements and early childhood neuro development: Evidence from a prospective birth cohortin rural Bangladesh.Environ Int. 2022 Jun 24;166:107370. IF= 13.352

  3. ZhangR, Shen S, Wei Y, Zhu Y, Li Y, Chen J, Guan J, Pan Z, Wang Y, Zhu M,Xie J, Xiao X, Zhu D, Li Y, Albanes D, Landi MT, Caporaso NE, Lam S,Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeböller H,Wichmann HE, Rennert G, Arnold S, Brennan P, McKay JD, Field JK,Shete SS, Le Marchand L, Liu G, Andrew AS, Kiemeney LA,Zienolddiny-Narui S, Behndig A, Johansson M, Cox A, Lazarus P,Schabath MB, Aldrich MC, Dai J, Ma H, Zhao Y, Hu Z, Hung RJ, AmosCI, Shen H, Chen F,Christiani DC. A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-EthnicValidation in Asians. Journal of Thoracic Oncology. 2022 Apr 30:S1556-0864(22)00215-5. IF= 20.121

  4. ChenJ, Shen S, Li Y, Fan J, Xiong S, Xu J, Zhu C, Lin L, Dong X, Duan W,Zhao Y, Qian X, Liu Z, Wei Y, Christiani DC, Zhang R, Chen F.APOLLO: An accurate and independently validated prediction model of lower-grade gliomas overall survival and a comparative study of model performance. EBio Medicine. 2022 May;79:104007. IF= 11.205

  5. WeiY, Sha F, Zhao Y, Jiang Q, Hao Y, Chen F. Better modelling of infectious diseases: lessons from covid-19 inChina. BMJ.2021 Dec 1;375:n2365. IF= 93.333

  6. WeiY, Guan J, Ning X, Li Y, Wei L, Shen S, Zhang R, Zhao Y, Shen H,Chen F*.Global COVID-19 pandemic waves: Limited lessons learned worldwide over the past year. Engineering(Beijing).2021 Sep 14. IF= 12.834

  7. HuangH, Wei L, Chen X, Zhang R, Su L, Rahman M, Golam Mostofa M,Qamruzzaman Q, Zhao Y, Yu H, Wei Y, Christiani DC, Chen F.Cord serum elementomics profiling of 56 elements depicts risk of preterm birth: Evidence from a prospective birth cohort in rural Bangladesh. Environment International. 2021 Nov;156:106731. IF= 13.352

  8. WeiY, Huang H, Zhang R, Zhu Z, Zhu Y, Lin L, Dong X, Wei L, Chen X, LiuZ, Zhao Y, Su L, Chen F,Christiani DC. Association of Serum Mannose With Acute RespiratoryDistress Syndrome Risk and Survival. JAMANetwork Open.2021 Jan 4;4(1):e2034569. IF= 13.366

  9. DuM, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q,Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X,Wang M, Chen F,Christiani DC. Integrative omics provide biological and clinicalinsights into acute respiratory distress syndrome. Intensive Care Medicine.2021 Jul;47(7):761-771. IF= 41.787

  10. ChenX, Gao W, Li J, You D, Yu Z, Zhang M, Shao F, Wei Y, Zhang R, LangeT, Wang Q, Chen F,Lu X, Zhao Y. A predictive paradigm for COVID-19 prognosis based on the longitudinal measure of biomarkers. Briefingsin Bioinformatics.2021 Nov 5;22(6):bbab206. IF=13.994

  11. ShenS, Zhang R, Jiang Y, Li Y, Lin L, Liu Z, Zhao Y, Shen H, Hu Z, WeiY, ChenF.Comprehensive analyses of m6A regulators and interactive coding andnon-coding RNAs across 32 cancer types. Molecular Cancer.2021 Apr 13;20(1):67. IF=41.444

  12. ShenS, Wei Y, Li Y, Duan W, Dong X, Lin L, You D, Tardon A, Chen C,Field JK, Hung RJ, Liu G, Zhu D, Amos CI, Su L, Zhao Y, Hu Z, ShenH, Zhang R, ChenF,Christiani DC. A multi-omics study links TNS3 and SEPT7 to long-termformer smoking NSCLC survival. NPJPrecision Oncology.2021 May 17;5(1):39. IF= 10.169

  13. DongX, Ma G, ChenF.Age at diagnosis and prognosis among prostate cancer patientstreated with radiotherapy: evidenced from three independent cohortstudies. Annals of Oncology.2018 Sep 1;29(9):2019-2020. IF=14.196

  14. WeiY, Chen F.Lowering the P Value Threshold. JAMA.2018 Sep 4;320(9):934-935. IF=51.273



Selected Papers(collaboratorsin statistics)

  • QinS, Bi F, Gu S, Bai Y, Chen Z, Wang Z, Ying J, Lu Y, Meng Z, Pan H,Yang P, Zhang H, Chen X, Xu A, Cui C, Zhu B, Wu J, Xin X, Wang J,Shan J, Chen J, Zheng Z, Xu L, Wen X, You Z, Ren Z, Liu X, Qiu M, WuL, Chen F. Donafenib Versus Sorafenib in First-Line Treatment of Unresectableor Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label,Parallel-Controlled Phase II-III Trial.J Clin Oncol.2021 Sep 20;39(27):3002-3011. PMID: 34185551

  • ZhangY, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L,Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, ChenF,Han Y, Xie L, Ji Y. HINT1 (Histidine Triad Nucleotide-BindingProtein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5(Homeobox A5) Expression. Circulation.2021 Aug 24;144(8):638-654. PMID: 34098726.

  • FanY, Cheng Y, Li Y, Chen B, Wang Z, Wei T, Zhang H, Guo Y, Wang Q, WeiY, Chen F, Sha J, Guo X, Wang L. Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of Checkpoint Kinase 1 via Activating Mammalian Target of Rapamycin C1/RibosomalProtein S6 Kinase b-1 Pathway. Circulation.2020May 12;141(19):1554-1569. PMID: 32098494.

  • HuZ, Li Z, Yu J, Tong C, Lin Y, Guo X, Lu F, Dong J, Xia Y, Wen Y, WuH, Li H, Zhu Y, Ping P, Chen X, Dai J, Jiang Y, Pan S, Xu P, Luo K,Du Q, Yao B, Liang M, Gui Y, Weng N, Lu H, Wang Z, Zhang F, Zhu X,Yang X, Zhang Z, Zhao H, Xiong C, Ma H, Jin G, Chen F,Xu J, Wang X, Zhou Z, Chen ZJ, Liu J, Shen H, Sha J. Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun.2014 May 23;5:3857. PMID: 24852083.

  • JinG, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y,Chen J, Li H, Pan S, Chu M, Lu F, Yu D, Jiang Y, Dong J, Hu L, ChenY, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F,Wang X, Hu Z, Lin D, Shen H. Genetic variants at 6p21.1 and 7p15.3are associated with risk of multiple cancers in Han Chinese. AmJ Hum Genet.2012 Nov 2;91(5):928-34. PMID: 23103227

  • HuZ, Wu C, Shi Y, Guo H, Zhao X, Yin Z, Yang L, Dai J, Hu L, Tan W, LiZ, Deng Q, Wang J, Wu W, Jin G, Jiang Y, Yu D, Zhou G, Chen H, GuanP, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y,Zhang H, Yan Y, Ma H, Chen J, Chu M, Lu F, Zhang Z, ChenF,Wang X, Jin L, Lu J, Zhou B, Lu D, Wu T, Lin D, Shen H. Agenome-wide association study identifies two new lung cancersusceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet.2011 Jul 3;43(8):792-6. PMID: 21725308.

  • SheuCC, Gong MN, Zhai R, Bajwa EK, Chen F,Thompson BT, Christiani DC. The influence of infection sites ondevelopment and mortality of ARDS. Intensive Care Med.2010 Jun;36(6):963-70. PMID: 20229040

  • LiY, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, AakreJA, Allen MS, ChenF,Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS,Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J,Wang R, Zhang ZF, Christiani DC, Wu X, Yang P. Genetic variants and risk of lung cancer in never smokers: a genome-wide associationstudy. Lancet Oncol.2010 Apr;11(4):321-30. PMID: 20304703

  • ZhaiR, ChenF,Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS,Sheu CC, Wain JC, Christiani DC. Interactions among genetic variantsin apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol.2010 May 10;28(14):2445-51. PMID: 20385987

  • SheuCC, Zhai R, Wang Z, Gong MN, Tejera P, Chen F,Su L, Thompson BT, Christiani DC. Heme oxygenase-1 microsatellitepolymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. Intensive Care Med.2009 Aug;35(8):1343-51. PMID: 19526221