Zhang Ruyang

发布者：公共卫生学院发布时间：2022-10-25浏览次数：475

Associate Professor of  Epidemiology and Biostatistics

Theelected member of  the Outstanding Young Backbone Teacherof Qing Lan Project of Jiangsu Province

Theelected member of the Outstanding Young Level Academic Leadership Training Program of Nanjing Medical Member of  American Association for Cancer Research (AACR)

Member of  American Thoracic Society (ATS)

Member of  International Biostatistics Society(IBS)-China

RuyangZhang, PhD


Affiliation: School of  Public Health, Nanjing  Medical  University

Address: SPH building, 101  Longmian  Avenue,  Nanjing,  Jiangsu 211166

Email:zhangruyang@njmu.edu.cn

ORCIDID:https://orcid.org/0000-0003-3861-4297


Research Interest

  1. Gene-gene, gene-environment and environment-environment interaction study of risk and prognosis of complex diseases of respiratory system (e.g., lungcancer and ARDS)

  2. Risk  and  prognostic  prediction  model  construction  of  complex diseases

  3. Methodology of  clinical  trials

 

Education

2008.09-2013.06

Nanjing  Medical  University

Biostatistics

PhD

2003.09-2008.06

Nanjing  Medical  University

Preventive Medicine(Biostatistics)

B.Med


RESEARCH EXPERIENCES

2019.07-present

Nanjing  Medical University

Associate  Professor

2017.06-2019.06

Nanjing  Medical University

Assistant  Professor

2015.06-2017.05

Harvard  University

Postdoc  Fellow

2013.09-2015.05

Nanjing  Medical University

Assistant  Professor


Honors and Awards:

Research Awards

  1. Second Prize of Medical Scienceand Technology of Jiangsu Province (2020)

  2. Second  Prize of  Outstanding Scientific Research Achievement Award of Ministry of  Education of  China (2019)

  3. Third  Prize of  Excellent  Academic Paper of  Natural Science in Nanjing City (2018)

  4. Nanjing  Medical University  Excellent  Doctoral  Dissertation (2014)

  5. First  Prize of  Outstanding Paper Award  in  Annual Conference of China  Association of  Biostatistics (2012)

  6. Excellent  Student  Cadre  of  Jiangsu Province (2006)

Teaching Awards

  1. Excellent  Master Thesis of  Nanjing Medial University (2021, 2ndMentor)

  2. Third Prize of  Excellent Graduation Thesis for Higher Education Institutions of Jiangsu Province (2020, Mentor)

  3. Second  Prize of  National College Student Computer Design Competition (BigData Group), College Computer Course Teaching Steering Committee of  The Ministry of  Education of China, China (2020, Mentor)

  4. Successful Participant of  National Mathematical Contest in Modeling, China(2019, Mentor)

  5. First Prize of National SAS Data Analytics Champion, SAS China (2019,Mentor)

  6. First  Prize of National College Student Computer Design Competition (Big Data Group), College Computer Course Teaching Steering Committee of  The Ministry of Education of China, China (2019, Mentor)

  7. First  Prize of  National College Student Computer Design Competition(Digital Media Group), College Computer Course Teaching Steering Committee of  The Ministry of  Education of China, China (2019,Mentor)

  8. Zhao-XiBao  Faculty Fellowship, Nanjing Medical University, China (2019)

  9. Successful  Participant of  The Mathematical Contest in Modeling, USA (2019,Mentor)

  10. Second  Prize of  Asia  and  Pacific Mathematical Contest in Modeling, China(2018, Mentor)

  11. Excellent  Mentor of  Undergraduate (Clinical Medicine), Nanjing MedicalUniversity, China (2018)

  12. Second  Prize of  National SAS Data Analytics Champion, SAS China (2018,Mentor)

  13. Third  Prize of  National SAS Data Analytics Champion, SAS China (2018,Mentor)

  14. First  Prize of  National Massive Open Online Courses (MOOC) TeachingCompetition (Undergraduate Group), Educational Technology Branch ofChinese Medical Association, China (2018)

  15. Third  Prize of  National Institutions of  Higher  Learning  Micro-Course  Teaching  Competition (Medicine Group), Medicine Teaching inUniversity, China (2019)

  16. Third  Prize of Jiangsu Institutions of   Higher  Learning Micro-Course  Teaching Competition, Education Department of   Jiangsu Province,China (2018)


Ongoing Research Projects

  • NationalNatural Science Foundation of China. Amethodological study of interaction analysis and development ofprognostic prediction model of lung cancer based on summary data.PI: Ruyang Zhang.

  • Natural Science Foundation ofJiangsu Province. Amethodological study of gene-based gene-gene interaction analysis inmulti-omics data under information entropy framework.PI: Ruyang Zhang


Selected Papers(First or Corresponding author)

  1. Chen J#,Gao X#,Shen S#,Xu J, Sun Z, Lin R, Dai Z, Su L, Christiani DC, Chen F, ZhangR*,Wei Y*.Association of Longitudinal Platelet Count Trajectory with ICUMortality: A Multi-cohort Study. Frontiersin Immunology.2022. In Press.IF=8.786

  2. Zhang R#,Shen S#,Wei Y#,Zhu Y, Li Y, Chen J, Guan J, Pan Z, Wang Y, Zhu M, Xie J, Xiao X,Zhu D, Li Y, Albanes D, Landi MT, Caporaso N, Lam S, Tardon A, ChenC, Bojesen SE, Johansson M, Risch A, Bickeböller H, Wichmann HE,Rennert G, Arnold S, Brennan P, McKay J, Field JK, Shete SS,Marchand LL, Liu G, Andrew A, Kiemeney LA, Zienolddiny-Narui S,Behndig A, Johansson M, Cox A, Lazarus P, Schabath MB, Aldrich MC,Dai J, Ma H, Zhao Y, Hu Z, Hung RJ, Amos CI, Shen H*,Chen F*,Christiani DC*.A large-scale genome-wide gene-gene interaction study of lung cancersusceptibility in Europeans with a trans-ethnic validation inAsians. Journal ofThoracic Oncology.2022 Apr 30; 17(8):974-990. IF=20.121

  3. Chen J#,Shen S#,Li Y#,Fan J#,Xiong S, Xu J, Zhu C, Lin L, Dong X, Duan W, Zhao Y, Qian X, Liu Z,Wei Y, Christiani DC*,Zhang R*,Chen F*.APOLLO: an accurate and independently validated prediction model ofLower-grade gliomas overall survival and a comparative study.EBioMedicine.2022May;79:104007. IF=11.205

  4. Ji X#,Lin L#,Fan J#,Li Y, Wei Y, Shen S, Su L, Shafer A, Bjaanæs MM, Karlsson A, PlanckM, Staaf J, Helland Å, Esteller M, ZhangR*,Chen F*,Christiani DC. Epigenome-wide three-way interaction study identifiesa complex pattern between TRIM27,KIAA0226,and smoking associated with overall survival of early-stage NSCLC.Molecular Oncology.2022 Feb;16(3):717-731. IF=7.449

  5. Shen S#,Zhang R#,Jiang Y, Li Y, Lin L, Liu Z, Zhao Y, Shen H, Hu Z, Wei Y*,Chen F*. Comprehensive analyses of m6A regulators and interactivecoding and non-coding RNAs across 32 cancer types. MolecularCancer. 2021 Apr13;20(1):67. IF=41.444

  6. Shen S#,Wei Y#,Li Y, Duan W, Dong X, Lin L, You D, Tardon A, Chen C, Field JK, HungRJ, Liu G, Zhu D, Amos CI, Su L, Zhao Y, Hu Z, Shen H, ZhangR*,Chen F*,Christiani DC*.A multi-omics study links TNS3and SEPT7to long-term former smoking NSCLC survival. NPJPrecision Oncology.2021 May 17;5(1):39. IF=10.169

  7. Wei Y#,Huang H#,Zhang R#,Zhu Z, Zhu Y, Lin L, Dong X, Wei L, Chen X, Liu Z, Zhao Y, Su L,Chen F*,Christiani DC*.Association of Serum Mannose with Acute Respiratory DistressSyndrome Risk and Survival. JAMANetwork Open.2021 Jan; 4(1):e2034569. IF=13.366


  1. Ji X#,Lin L#,Shen S, Dong X, Chen C, Li Y, Zhu Y, Huang H, Chen J, Chen X, Wei L,He J, Duan W, Su L, Jiang Y, Fan J, Guan J, You D, Shafer A, BjaanæsMM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Wei Y*,Zhang R*,Chen F, Christiani DC. Epigenetic-smoking interaction revealshistologically heterogeneous effects of TRIM27DNA methylation on overall survival among early-stage NSCLCpatients. MolecularOncology. 2020Nov; 14 (11): 2759-2774. CoverPaper, IF=6.603

  2. Zhang R#,*,Chen C#,Dong X#,Shen S, Lai L, He J, You D, Lin L, Zhu Y, Huang H, Chen J, Wei L,Chen X, Li Y, Guo Y, Duan W, Liu L, Su L, Shafer A, Fleischer T,Bjaanæs MM, Karlsson A, Planck M, Wang R, Staaf J, Helland Å,Esteller M, Wei Y*,Chen F*,Christiani DC. Independent validation of early-stage non-small celllung cancer prognostic scores incorporating epigenetic andtranscriptional biomarkers with gene-gene interactions and maineffects. Chest.2020 Aug; 158 (2): 808-819.IF=9.410

  3. Zhang R#,Lai L#,Dong X, He J, You D, Chen C, Lin L, Zhu Y, Huang H, Shen S, Wei L,Chen X, Guo Y, Liu L, Su L, Shafer A, Moran S, Fleischer T, BjaanæsMM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Wei Y*,Chen F*,Christiani DC. SIPA1L3 methylation modifies the benefit of smokingcessation on lung adenocarcinoma survival: An epigenomic–smokinginteraction analysis. MolecularOncology. 2019May;13(5):1235-1248.2020 World CancerDay Paper (WHO),IF=6.574

  4. Zhang R#,Wang Z, Tejera P, Frank AJ, Wei Y, Su L, Zhu Z, Guo Y, Chen F, BajwaEK, Thompson BT, Christiani DC*.Late-onset moderate to severe acute respiratory distress syndrome isassociated with shorter survival and higher mortality: a two-stageassociation study. IntensiveCare Medicine.2017 Mar; 43(3):399-407. IF=15.008

  5. Zhang R#,Chu M#,Zhao Y#,Wu C, Guo H, Shi Y, Dai J, Wei Y, Jin G, Ma H, Dong J, Yi H,Bai J, GongJ, Sun C, Zhu M, Wu T, Hu Z, Lin D, Shen H, Chen F*.A genome-wide gene-environment interaction analysis for tobaccosmoke and lung cancer susceptibility. Carcinogenesis.2014 Jul; 35(7): 1528-1535. IF=5.334

  6. Chu M#,Zhang R#,Zhao Y#,Wu C, Guo H, Zhou B, Lu J, Shi Y, Dai J, Jin G, Ma H, Dong J, Wei Y,Wang C, Gong J, Sun C, Zhu M, Qiu Y, Wu T, Hu Z, Lin D, Shen H, ChenF*.A genome-wide gene-gene interaction analysis identifies an epistaticgene pair for lung cancer susceptibility in Han Chinese.Carcinogenesis.2014 Mar 9, 35(3): 572-577.IF=5.334