Zhao Yang

发布者：公共卫生学院发布时间：2022-10-25浏览次数：569

Yang Zhao PhD

Professor of Biostatistics

Head of the Department of Biostatistics, School of Public Health

Director of the Biomedical Big-Data Center

Nanjing Medical University

101 Longmian Avenue, Nanjing, Jiangsu, China, 211166

zhaoyang@njmu.edu.cn



Research Interest

Causal Inference, Statistical Methods for -Omics Data, Clinical Trial, Real World Studies



Education

2000 Bachelor  of  Clinical Medicine, Nantong University

2003 Master  of  Epidemiology and Biostatistics, Nantong University

2009 Doctor  of  Epidemiology and Biostatistics, Nanjing Medical University



Working Experience

2003-2005 Nanjing Medical University Teaching  Assistant

2005-2013 Nanjing Medical University  Instructor

2010-2012 Harvard School of Public  Health  Post-Doc

2013-2019 Nanjing Medical University Associate Professor

2019-         Nanjing Medical University Professor


Social Activities

2022-Committee  of  Biostatistics, Jiangsu Society  of  Preventive Medicine  Chair


2021-Committee  of  Biostatistics, Chinese Society  of  Preventive  Medicine

Vice Chair


2019-Committee  of  Statistical  Experts, Chinese Society of  Clinical  Oncology

Vice Chair


2017-Committee of Statistical Education, Chinese Pharmaceutical Education Society

Vice Chair


2017-Committee of Statistical Education, Chinese Medical Information and Health Big Data Society

Vice Chair

2017-China Branch of International Biometrics Society

Vice Secretary


Honor

2022  The 3rd   Level  in  333  Project of Jiangsu Province

2017  Qin-Lan  Project  of  Jiangsu Province

2014  Qin-Lan  Project  of  Jiangsu Province




Funding

2022-          Estimation of  ITE in Real World Studies

NSFC,Primary Investigator

2019-2020  A Study on the causal inference for high dimensional biomedical data based on random forests

NSFC,Primary Investigator


2013-2018  Developing Statistical Methods on Integrating Common and Rare Variants to Predict Lung Cancer Risk

NSFC,Primary Investigator


2009-2012  A  Study on Risk Score Function Method for the Cancer Diagnostic and Prognostics Evaluation Based on Gene Expression Data

NSFC,Primary Investigator




Selected Publications

  1. You,D., Wang, D., Wu, Y., Chen, X., Shao, F., Wei Y., Zhang R., LangeT., Ma H., Xu H., Hu Z., Christiani, D., Shen H., Chen F., ZhaoY.. Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study. BMC Med 20, 203 (2022).https://doi.org/10.1186/s12916-022-02400-6

  2. TangY, You D, Yi H, Yang S*and Zhao Y*(2022) IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score. Front. Genet. 13:801397.doi: 10.3389/fgene.2022.801397

  3. ZhangH., Wang Z., Tang Y., Chen X., You D., Wu Y., Yu M., Chen W., Zhao Y. *,Chen X. Prediction of acute kidney injury after cardiac surgery: model development using a Chinese electronic health record dataset. JTransl Med 20, 166(2022). https://doi.org/10.1186/s12967-022-03351-5

  4. Sun J,Lyu R, Deng L, Li Q, Zhao Y*,Zhang Y* (2022) SMetABF: A rapid algorithm for Bayesian GWASmeta-analysis with a large number of studies included. PLOS Computational Biology 18(3):e1009948. https://doi.org/10.1371/journal.pcbi.1009948

  5. Guan,Jinxing#,Zhao,Yang*#,Wei, Yongyue, Shen, Sipeng, You, Dongfang, Zhang, Ruyang, Lange,Theis and Chen, Feng*. 'Transmission dynamics model and the coronavirus disease 2019 epidemic: applications andchallenges' Medical Review,vol. , no. , 2022. https://doi.org/10.1515/mr-2021-0022

  6. WuY, Bai J, Zhang M, Shao F, Yi H, You D* and ZhaoY*(2022)Heterogeneity of Treatment Effects for Intensive Blood PressureTherapy by Individual Components of FRS: An Unsupervised Data-Driven Subgroup Analysis in SPRINT and ACCORD. Front.Cardiovasc. Med. 9:778756.doi: 10.3389/fcvm.2022.778756

  7. ZhouJ#,  Bai J#, Yue Y#, Chen X, Lange T, You D*,ZhaoY*(2022). Association of Hypokalemia Incidence and Better Treatment Response in NSCLC Patients: A Meta-Analysis and Systematic Review on Anti-EGFR Targeted Therapy Clinical Trials.' FrontOncol11: 757456.

  8. ZhangM#, Xu K#, Dai Q#, You D, Yu Z, Bao C*,ZhaoY*.A dynamic model for individualized prognosis prediction in patientswith avian influenza A H7N9. AnnTransl Med 2022;10(3):149.doi: 10.21037/atm-21-4126

  9. SongR, Shi Y, Li X, Zhu J, Zhang H, Li K, Wang B, Zhang H, Yang Y, GaoL,Zhao Y* and Zhang Z* (2021) Potential of Antithrombin III as a Biomarker of Antidepressive Effect in Major Depressive Disorder. Front.Psychiatry12:678384. doi: 10.3389/fpsyt.2021.678384

  10. BaoS#, Yue Y#, Hua Y#, Zeng T, Yang Y, Yang F, Yan X, Sun C, Yang M, FuZ, Huang X, Li J, Wu H, Li W*,Zhao Y*,Yin Y*. Safety profile of poly (ADP-ribose) polymerase (PARP)inhibitors in cancer: a network meta-analysis of randomizedcontrolled trials. AnnTransl Med 2021;9(15):1229.doi: 10.21037/atm-21-1883.

  11. Chen,X.#, W. Gao#, J. Li#, D. You#, Z. Yu, M. Zhang, F. Shao, Y. Wei, R.Zhang, T. Lange, Q. Wang*, F. Chen*,X. Lu*, and Y.Zhao*, Apredictive paradigm for COVID-19 prognosis based on the longitudinal measure of biomarkers. BriefBioinform,2021.

  12. YachenShi#, Ruize Songa#, Zan Wanga#, Hongxing Zhang, Jianli Zhu, YuanpingYue,YangZhao*,Zhijun Zhang*(2021). Potential clinical value of circular RNAs asperipheral biomarkers for the diagnosis and treatment of majordepressive disorder. EBioMedicine,2021,66,10337.

  13. DongfangYou#; Mingzhi Zhang#; Wenjing He; Danhua Wang; Yang Yu; Zhaolei Yu;Theis Lange; Sheng Yang; Yongyue Wei; Hongxia Ma; Zhibin Hu;Hongbing Shen; Feng Chen*; YangZhao*(2021).Associationbetween dietary sodium, potassium intake and lung cancer risk:evidence from the prostate, lung, colorectal and ovarian cancerscreening trial and the Women’s Health Initiative.Translational Lung Cancer Research,2021, 10(1): 45-56.

  14. XinChen, Liangmin Wei, Hui Huang, Ruyang Zhang,LiSu, Mahmudur Rahman,Md Golam Mostofa, Quazi Qamruzzaman, Hao Yu, YangZhao∗,Yongyue Wei∗,David C Christiani∗andFeng Chen(2021)Assessmentof individual and mixture effects of element exposure measured inumbilical cord blood on birth weight in Bangladesh Environ.Res. Commun.3 105001.

  15. ZhaoY., Wei Y.Y., Shen S.P., ZhangM.Z., Chen F. (2020). Appealing for efficient, well organized clinical trials on COVID-19. Annals of Translational Medicine.2020. doi: 10.21037/atm-20-2429.

  16. YouD.F.#, Qin N.#, Zhang M.Z., Dai J.Z., Du M.L., Wei Y.Y., Zhang R.Y.,Hu Z.B., Christiani D.C., ZhaoY.*, Chen F. *. (2020)“Identification of genetic features associated with fineparticulate matter (PM2.5) modulated DNA damage using improved random forest analysis”. Gene740:144570.

  17. Han,B., K. Li, Q. Wang, L. Zhang, J. Shi, Z. Wang, Y. Cheng, J. He, Y.Shi, Y. Zhao, H. Yu, Y. Zhao,W. Chen, Y. Luo, L. Wu, X. Wang, R. Pirker, K. Nan, F. Jin, J. Dong,B. Li and Y. Sun (2018). 'Effect of Anlotinib as a Third-Lineor Further Treatment on Overall Survival of Patients With Advanced Non-Small Cell Lung Cancer: The ALTER 0303 Phase 3 Randomized Clinical Trial.' JAMA Oncol 4(11): 1569-1575.

  18. XuZ, Yue Y, Bai J, Shen C, Yang J, Huang X, ZhaoY∗,Li Y∗. Association between oral contraceptives and risk of hemorrhagic stroke: a meta-analysis of observational studies. Arch Gynecol Obstet.2018 May;297(5):1181-1191. doi: 10.1007/s00404-018-4723-7. Epub 2018Feb 19. PMID: 29460112.

  19. Tang,W. #,J. Tang#,Y. Zhao#,Y. Qin, G. Jin, X. Xu, H. Zhu,H. Shen, X. Wang, Z. Hu and Y. Xia (2016). 'Exome-Wide Association Study Identified New Risk Loci for Hirschsprung'sDisease.' Mol Neurobiol.

  20. Chu,M., R. Zhang, Y. Zhao,C. Wu, H. Guo, B. Zhou, J. Lu, Y. Shi, J. Dai, G. Jin, H. Ma, J.Dong, Y. Wei, C. Wang, J. Gong, C. Sun, M. Zhu, Y. Qiu, T. Wu, Z.Hu, D. Lin, H. Shen and F. Chen (2014). 'A genome-wide gene-gene interaction analysis identifies an epistatic gene pair forlung cancer susceptibility in Han Chinese.' Carcinogenesis35(3): 572-577.

  21. Zhao,Y., Q. Wei, L. Hu, F. Chen, Z.Hu, R. S. Heist, L. Su, C. I. Amos, H. Shen and D. C. Christiani(2014). 'Polymorphisms in MicroRNAs are associated withsurvival in non-small cell lung cancer.' Cancer Epidemiol Biomarkers Prev 23(11): 2503-2511.

  22. Zhao,Y., F. Chen, R. Zhai, X. Lin,N. Diao and D. C. Christiani (2012). 'Association test based on SNP set: logistic kernel machine based test vs. principal componentanalysis.' PLoS One7(9): e44978.

  23. Zhao,Y., F. Chen, R. Zhai, X. Lin,Z. Wang, L. Su and D. C. Christiani (2012). 'Correction forpopulation stratification in random forest analysis.' IntJ Epidemiol 41(6):1798-1806.

  24. Zhao,Y., H. Yu, Y. Zhu, M.Ter-Minassian, Z. Peng, H. Shen, N. Diao and F. Chen (2012).'Genetic association analysis using sibship data: a multilevelmodel approach.' PLoS One 7(2): e31134.

  25. Zhao,Y., L. Wang, H. B. Shen, Z. X.Wang, Q. Y. Wei and F. Chen (2007). 'Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and bloodlead levels: a meta-regression analysis.' JToxicol Environ Health A70(23): 1986-1994.