Lu Chuncheng

发布者：公共卫生学院发布时间：2022-10-24浏览次数：481

Chuncheng Lu

MD,Ph.D./Professor

DeputyDean, School of Public Health, Nanjing Medical University

ViceDirector, Nanjing Municipal Center for Disease Control and Prevention

Principle Investigator (PI), State Key Laboratory of Reproductive Medicine(SKLRM), Nanjing Medical University

Principle Investigator (PI), Key Laboratory of Modern Toxicology of Ministry ofEducation, Nanjing Medical University

Tel:86-25-8686-8420

CellPhone: +86(0)13770633646

E-mail:chunchenglu@njmu.edu.cn


Research Interests

The mechanism studies of environmental, genetic and epigenetic risk factors in reproductive and developmental health.

Education

2015.10-2017.01:Visiting Scholar in Data Interpretation and Genetic Diagnosis, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

2005.09-2010.07:Ph.D. in Reproductive Toxicology, Nanjing Medical University, Nanjing, PR China

2000.09-2005.07:B.Sc in Preventive Medicine, Nanjing Medical University, Nanjing, PR, China

Honors and Awards

2018,Young academic leaders of Jiangsu Province (First Class)

2022,333 Project of Jiangsu Province (Third Class)

Ongoing Research Projects

The genetic analysis and molecular mechanistic study in non-obstructiveazoospermia pedigrees. National Natural Science Foundation of China(No. 82071700)

The genetic study of clinical cohort and intervetion on the offspringconceived and born through assisted reproduction technology. NationalKey Research and Development Program of China (No. 2021YFC2700605)

Selected Publications(*Corresponding Author)

  1. Huang Z, Yu H, Du G, Han L, Huang X, Wu D, Han X, Xia Y, Wang X*,Lu C*. Enhancer RNA lnc-CES1-1 inhibitsdecidual cell migration by interacting with RNA-binding protein FUSand activating PPARγ in unexplained recurrent pregnancy loss. MolTher Nucleic Acids. 2021 Feb 18; 24:104-112.

  2. Lu C, Zhang Y, Qin Y, Xu Q, Zhou R, Cui Y, Zhu Y,Zhang X, Zhang J, Wei X, Wang M, Hang B, Mao J, Snijders AM, Liu M,Hu Z, Shen H, Zhou Z, Guo X, Wu X, Wang X*, Xia Y*. Human Xchromosome exome sequencing identifies BCORL1 as contributor tospermatogenesis. J Med Genet. 2021 Jan;58(1):56-65.

  3. Fan Y, Li X, Xu Q, Zhang Y, Yang X, Han X, Du G, Xia Y, Wang X, LuC*. Serum albumin mediates the effect of multiple per- andpolyfluoroalkyl substances on serum lipid levels. EnvironPollut. 2020 Nov;266(Pt 2):115138.

  4. Fan Y, Qin Y, Chen M, Li X, Wang R, Huang Z, Xu Q, Yu M, Zhang Y,Han X, Du G, Xia Y, Wang X*, Lu C*.Prenatal low-dose DEHP exposure induces metabolic adaptation andobesity: Role of hepatic thiamine metabolism.JHazard Mater. 2020 Mar 5;385:121534.

  5. Huang Z, Xu B, Huang X, Zhang Y, Yu M, Han X, Song L, Xia Y, Zhou Z,Wang X, Chen M*, Lu C*.Metabolomics reveals the role of Acetyl-L-carnitine metabolism inγ-Fe2O3 NP- induced embryonic development toxicity via mitochondriadamage. Nanotoxicology. 2019 Mar;13(2):204-220

  6. Huang Z, Du G, Huang X, Han L, Han X, Xu B, Zhang Y, Yu M, Qin Y,Xia Y, Wang X and Lu C*. Theenhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplainedrecurrent pregnancy loss (URPL) by activating CXCL8 and NF-kBpathway. Ebiomedicine. 2018 Dec;38:162-170.

  7. Yu M, Du G, Xu Q, Huang Z, Huang X, Qin Y, Han L, Fan Y, Zhang Y,Han X, Jiang Z, Xia Y, Wang X, Lu C*.Integrated analysis of DNA methylome and transcriptome identifiedCREB5 as a novel risk gene contributing to recurrent pregnancy loss.EBioMedicine. 2018 Sep;35:334-344.

  8. Qin Y, Ji J, Du G, Wu W, Dai J, Hu Z, Sha J, Hang B, Lu C*,Xia Y, Wang X. Comprehensive Pathway-Based Analysis IdentifiesAssociations of BCL2, GNAO1 and CHD2 with Non ObstructiveAzoospermia Risk. Hum Reprod. 2014 Apr;29(4):860-866.

  9. Lu C, Zhang F, Yang H, Xu M, Du G, Wu W, An Y, Qin Y,Ji G, Han X, Gu A, Xia Y, Song L, Wang S, Jin L, Wang X. Additionalgenomic duplications in AZFc underlie the b2/b3 deletion-associatedrisk of spermatogenic impairment in Han Chinese population. HumMol Genet. 2011; 20(22):4411-4421.

  10. Lu C, Zhang J, Li Y, Xia Y, Zhang F, Wu B, Wu W, Ji G,Gu A, Wang S, Jin L, Wang X. The b2/b3 subdeletion shows higher riskof spermatogenic failure and higher frequency of complete AZFcdeletion than the gr/gr subdeletion in a Chinese population. HumMol Genet. 2009; 18(6):1122-1130.