Wang Shoulin

发布者：公共卫生学院发布时间：2022-10-24浏览次数：427

Head and Prof.,Department of  Occupationaland Environmental Health 

School of  Public Health, Nanjing Medical University

Chairman , Jiangsu Society of  Toxicology (JSSOT)

Member , Council of  Chinese Society of Toxicology (CST)

Deputy Director, Professional Committee of  Reproductive Toxicology, CST

Member,Council of  Jiangsu Genetic Society (JGS)

wangshl@njmu.edu.cn

王守林,　博士、教授

Shou-Lin Wang,Ph.D.



Research Interest

Biotransformation and Target Toxicity

Biomarker and Health Risk Assessment

 

Education

Nanjing  Medical  College, Preventive  Medicine, B.Sc. (1986.9-1991.7)

Nanjing  Medical  University, Occupational  and  Environmental Health, M.Sc.(1996.9-1999.7)

Nanjing  Medical  University, Occupational  and  Environmental Health, Ph.D.(2002.9-2006.7)

National  University  of  Singapore, Singapore,  Environmental  Health,VisitingScholar (1999.10-2000.4)

University  of   Medicine and Dentistry of  New Jersey (Current Rutgers University), USA, Molecular Toxicology, Visiting Scholar (2003.4-2006.3)


Honors and Awards:

2002  First  Class, Jiangsu Provincial Science & Technology Award (Rank No. 2)

2010   Second  Class, Science& Technology Award of  Ministry of  Education (Rank No. 2

2010  Second  Class, Jiangsu Provincial Science & Technology Award (Rank No. 3)

2014   Outstanding Young and Middle-aged Experts of  Jiangsu Province


Selected Research Projects

  1. PI,Structural  factors  and  mechanisms  of  CYP1A1  expression  regulated  by polycyclic aromatic hydrocarbons via m6A modification.NSFC,82173562

  2. PI,Molecular  mechanisms of testicular CYP2A5-mediated metabolic activation of5-HMF targeting spermatocytes to induce spermatogenesis disorders inmice.NSFC, 81973091

  3. PI, Toxiceffects and molecular mechanisms of important components ofatmospheric fine particulate matter-induced respiratory system basedon in situ metabolism strategies. NSFC, 91743205

  4. PI, Therole and mechanism of CYP3A65 in the metabolism of BDE47-induced thedevelopmental abnormalities in zebrafish. NSFC, 81573194

  5. PI, Therole of miRNAs as potential biomarkers in respiratory tumors inducedby CYP2A13-mediated metabolic activation of AFB1. NSFC, 81372956

  6. PI, Therole and mechanism of  CYP3A in the biotransformation ofBDE47-induced spermatogenesis disorders. NSFC, 81172695

  7. PI, Study  on the biomarker of  pyrethroid pesticides based on in vitrometabolic pathways. NSFC, 30972508

  8. PI, The role of CYP2A13 in the metabolic activation of AFB1-inducedmalignant transformation. NSFC, 30771782

  9. PI,Molecular mechanism of spermatogenesis abnormality induced byenvironmental factors. National 973 project, 2009CB941701


Selected Peer Review Publications

  1. Chen C,Zhang D, Yuan A, Shen J, Wang L, WangSL*.A novel approachto predict the comprehensive EROD potency: Mechanism-based curvefitting of CYP1A1 activity by PAHs. SciTotal Environ.2022,843:157052.

  2. Wang C, ZhuJ, Gong X, Liang Y, Xu S, Yu Y, Yang L, Xu J, WangSL*.Bioaccumulation ofBDE47 in testes by  TiO2nanoparticles aggravates the reproductive impairment of malezebrafish by disrupting intercellular junctions. Nanotoxicology,2021,15(8):1073-1086.

  3. Chen C, Min Y, Li X, Chen D,Shen J, Zhang D, Sun H, Bian Q, Yuan H, WangSL*. Mutagenicityrisk prediction of PAH and derivative mixtures by in silicosimulations oriented from CYP compound I-mediated metabolicactivation. Sci TotalEnviron.2021,787:147596.

  4. Li S, ShaoW, Wang C, Wang L, Xia R, Yao S, Du M, Ji X, Chu H, Zhang Z, WangM*, WangSL*.Identification ofcommon genetic variants associated with serum concentrations of p,p’-DDE innon-occupational populations in eastern China.Environ Int.2021, 152:106507.

  5. Chen C, Shen J, Yang L, ZhangW, Xia R, Huan F, Gong X, Wang L, Wang C, Yuan H, WangSL*. Identificationof structural properties influencing the metabolism of polycyclicaromatic hydrocarbons by cytochrome P450 1A1. SciTotal Environ.2021,758:143997.

  6. Yu Y, Wang C, Zhang X, Zhu J,Wang L, Ji M, Zhang Z, Ji XM, WangSL*. Perfluorooctanesulfonate disrupts the blood brain barrier through the crosstalkbetween endothelial cells and astrocytes in mice.Environ Pollut.2020,256:113429.

  7. Qiu LL, Wang C, Yao S, Li N, HuY, Yu Y, Xia R, Zhu J, Ji M, Zhang Z, and WangSL*. Fenvalerateinduces oxidative hepatic lesions through an overload ofintracellular calcium triggered by the ERK/IKK/NF-kB pathway. FASEBJ2019, 33(2):2782-2795

  8. Wang C, Yang L, Hu Y, Zhu J, XiR, Yu Y, Shen J, Zhang Z, WangSL*.Isoliquiritigenin as an antioxidant phytochemical ameliorates thedevelopmental anomalies of zebrafish induced by2,2’,4,4’-tetrabromodiphenyl ether. SciTotal Environ.2019,666:390-398.

  9. Ji M, Zhang Z, Li N, Xia R,Wang C, Yu Y, Yao S, Shen J, WangSL*. Identificationof 5-hydroxymethylfurfural in cigarette smoke extract as a newsubstrate metabolically activated by human cytochrome P450 2A13.Toxicol Appl Pharmacol2018;359:108-117.

  10. Wang Y, Zhang Z, Wang H, ZhangY, Ji M, Xu H, Wang C, Sun Z, Gao W, and WangSL*. miR-138-1*regulates aflatoxin B1-induced malignant transformation of BEAS-2Bcells by targeting PDK1. ArchToxicol2016;90(5):1239-1249