Zhang Zhengdong

张正东,　博士,二级教授

Zhengdong Zhang,MD, PhD

Professor of  Occupational Medicine and Environmental Health

Director of  the Key Laboratory of Modern Toxicology, Ministry of Education,Nanjing Medical University

Email:zdzhang@njmu.edu.cn

Research Interest

• Environment, Genetic/Epigeneticand Cancer

• EnvironmentalRisk Exposure and Human Hazard

Education

• Nanjing Medical College,Preventive Medicine, B.S. (1982.9-1987.7)

• Shanghai Medical University,Environmental Health, M.S. (1991.9-1994.7)

• Shanghai MedicalCollege,Fudan University, Occupational Health, Ph.D. (1996.9-2000.7)

• The University of Texas, MD Anderson Cancer Center, USA, CancerMolecular Epidemiology,PostdoctoralFellow (2002.8-2005.8)

Honors and Awards

• Most Cited Chinese Researchers (Zhengdong Zhang) (2020, 2021)

• Ranking oftop 100 Chinese experts with academics influence (Zhengdong Zhang)(2021)

• Outstanding Professor of Nanjing Medical University (First Class) (2018)

• Second Prize Award for Natural Sciences,Ministry of Education(Rank First) (2012)

• Leader of Science and Technology Innovation Group of Jiangsu Province (2010)

Recent Research Projects

• PI,Study of epigenetic regulation mechanism of exosomal ncRNAs inbladder toxicity induced by cigarette smoke condense.NSFC, 82130096

• PI,Research,developmentand evaluation of new screening and intervention technology forupper gastrointestinal cancer,MOST, 2018YFC1313102

• PI,Thestudy on role and mechanism of exosomal let-7i-5p mediating PM2.5exposure-inducedasthma in children.NSFC, 81973095

• PI,The association and its mechanism study of genome-wide CpG-SNPs withrisk of early-onset gastric cancer. NSFC, 81773539

• PI,Genetic variants of long noncoding RNA on risk of bladder cancer andmolecular mechanism, NSFC, 81473050

Selected Papers

1. Rui Zheng,Mulong Du, Man Tian, Zhaozhong Zhu, Chengcheng Wei, Haiyan Chu, CongGan, Jiayuan Liang, Renjie Xue, Fang Gao, Zhenguang Mao, MeilinWang, Zhengdong Zhang.Fine particulate matter induces childhood asthma attacks viaextracellular vesicle-packaged let-7i-5p-mediated modulation of theMAPK signaling pathway. Adv Sci. 2022 Jan;9(3):e2102460.

2. HantingLiu,JingjingGu,Zhengkai Huang,ZhichaoHan,JunyiXin,LinYuan,MulongDu,HaiyanChu,MeilinWang,Zhengdong Zhang.Fine particulate matter induces METTL3-mediated m⁶Amodification of BIRC5 mRNA in bladder cancer. J Hazard Mater.2022 Sep 5;437:129310.

3. Qi Yuan,Huanhuan Zhu, Hanting Liu, Meilin Wang, Haiyan Chu, Zhengdong Zhang.METTL3 regulates PM 2.5-induced cell injury by targeting OSGIN1 inhuman airway epithelial cells. J Hazard Mater. 2021 Aug5;415:125573.

4. Junyi Xin,Mulong Du, Xia Jiang, Yanling Wu, Shuai Ben, Rui Zheng, Haiyan Chu,Shuwei Li, Zhengdong Zhang,Meilin Wang.Systematic evaluation of the effects of genetic variants onPIWI-interacting RNA expression across 33 cancer types. NucleicAcids Res.2021 Jan 11;49(1):90-97.

5. Mulong Du,Rui Zheng, Gaoxiang Ma, Haiyan Chu, Jiafei Lu, Shuwei Li, Junyi Xin,Na Tong, Gang Zhang, Weizhi Wang, Fulin Qiang, Weida Gong, QinghongZhao, Guoquan Tao, Jinfei Chen, Zhifang Jia, Jing Jiang, GuangfuJin, Zhibin Hu, Hongbing Shen, Meilin Wang, Zhengdong Zhang.Remote modulation of lncRNA GCLET by risk variant at 16p13underlying genetic susceptibility to gastric cancer. Sci Adv. 2020May 20;6(21):eaay5525.