Zhou Jianwei

Distinguished Professor , Occupationaland Environmental Health

Activemember of America Association of  Cancer Research (AACR)

Member of  International Regulatory Peptide Society (IRPS)

Vice President of  Chinese Society of  Toxicology (CSOT)

Vice President of  China Biomedical Industry Chain Innovation and Transformation Alliance (CBICITA)

Honorary President of Jiangsu Society of Toxicology (JSSOT)

jwzhou@njmu.edu.cn

周建伟,　博士，教授

Jianwei Zhou, MD, PhD

Research Interest

The Structure and  Function of  Environmental Responsive Genes, Cancer and Aging

Environmental Pollution/Occupational Harzard and Human Health

Education and Training

Nanjing  Medical College, Preventive Medicine, B.S. (1978.3-1982.12)

Nanjing  Medical University, Occupational Medicine & Environmental Health,Ph.D. (2000.9—2003.7)

Sun  Yat-SenMedical University,  Occupational Health, Visiting Scholar of  ChinaMedical Board (CMB) (1993.8-1994.7)

The  University of  California at Davis (UC Davis), CA, USA, Division ofInternal Medicine, Visiting Scholar (1996.3-1998.3)

Honors and Awards:

2005   The 2^nd Prize of  Science and Technology Progress, Jiangsu Province

2007  Young  and  middle-agedleading  scientific and technological talents of '333 Talent  Training Project', Jiangsu Province

2012  The 2^ndPrize of  Natural Sciences, Ministry of  Education

2013  Outstanding  Teacher of  Nanjing Medical University

Ongoing Research Projects

PI,The  role  of  intestinal  epithelial  dy splasia  induced  by JWA  gene  deletionin  aging  and  its  prevention  and treatment.NSFC,81973156

Selected Publications

1. Zhou Y, Liu JW, Li X, Wang LM,Hu LR, Li AP, Zhou JW.JAC4 Protectsfrom X-ray Radiation-Induced Intestinal Injury by JWA-MediatedAnti-Oxidation/Inflammation Signaling. Antioxidants(Basel) 2022 Jun; 11(6): 1067.

2. Zhai ZR, Ren YL, Shu CJ, ChenDY, Liu X, Liang Y, Li AP, ZhouJW. JAC1 targetsYY1 mediated JWA/p38 MAPK signaling to inhibit proliferation andinduce apoptosis in TNBC. CellDeath Discov. 2022; 8:169. Published online 2022 Apr5. doi: 10.1038/s41420-022-00992-9

3. Cui JH, Shu CJ, Xu J, Chen DY,Li J, Ding K, Chen MJ, Li AP, He JD, Shu YQ, Yang LQ, Zhang RW, ZhouJW. JP1 suppressesproliferation and metastasis of melanoma through MEK1/2 mediatedNEDD4L-SP1-Integrin αvβ3 signaling. Theranostics,2020, doi:10.7150/thno.45843.

4. Chen JJ, Ren YL, Shu CJ, ZhangY, Chen MJ, Xu J, Li J, Li AP, Chen DY, He JD, Shu YQ, ZhouJW. JP3, anantiangiogenic peptide, inhibits growth and metastasis of gastriccancer through TRIM25/SP1/MMP2 axis. JExp Clin Cancer Res,2020, doi: 10.1186/s13046-020-01617 -813046- 2020-1617

5. Xu W, Chen Q, Wang Q, Sun Y,Wang S, Li A, Xu S, Røe OD, Wang M, Zhang R, Yang L, ZhouJW. JWA reversescisplatin resistance via the CK2-XRCC1 pathway in human gastriccancer cells. CellDeath Dis. 2014 Dec4;5:e1551.

6. Chen Y, Huang Y, Huang Y, Xia X,Zhang J, Zhou Y, Tan Y, He S, Qiang F, Li A, Røe OD, Li G, ZhouJW. JWA suppressestumor angiogenesis via Sp1-activated MMP-2 and its prognosticsignificance in human gastric cancer. Carcinogenesis (2014)35 (2): 442-451

7. Wang S, Wu X, Zhang J, Chen Y,Xu J, Xia X, He S, Qiang F, Li A, Shu Y, Røe OD, Li G, ZhouJW. CHIP functions asa novel suppressor of tumor angiogenesis with prognosticsignificance in human gastric cancer. Gut.2013 Apr;62(4):496-508.

8. Wang S, Wu X, Chen Y, Zhang J,Ding J, Zhou Y, He S, Tan Y, Qiang F, Bai J, Zeng J, Gong Z, Li A,Li G, Røe OD, Zhou J. Prognostic and Predictive Role of JWA andXRCC1 Expressions in Gastric Cancer. ClinCancer Res. 2012 May15;18(10):2987-2996.

9. Bai J, Zhang JB, Wu J, Shen LL,Zeng JY, Ding JJ, Wu Y, Gong ZH, Li AP, Xu S, ZhouJW and Li G. JWAregulates melanoma metastasis by integrin avb3 signaling. advanceonline publication. Oncogene 2010,29: 1227-1237.

10. Wang SY, Gong ZH, Chen R, LiuYR, Li AP, Li G, ZhouJW. JWA regulatesXRCC1 and functions as a novel base excision repair protein inoxidative-stress-induced DNA single-strand breaks. NucleicAcids Res. 2009Apr;37(6):1936-50.