Curriculum Vitae
Jun Wang
Deputy director of the Office of China International Cooperation Center for Environment and Human Health (Nanjing Medical University)
Professor of Department of Toxicology
Member of the Youth Committee of the Chinese Toxicology Society
Member of Neurotoxicology Committee of Chinese Toxicology Society
Member of Immunotoxicology Committee of China Toxicology Society
Email: wangjun@njmu.edu.cn Telephone:86-25-86868431
王军，博士
Jun Wang，PhD
Research Interest
l The association between environmental endocrine disruptions exposure and neuro degenerative and psychiatric diseases.
l The effects and mechanisms of Methamphetamine (METH) induced neuro degenerative diseases and depression.
l Depression markers screening and technical application.
Education
l B.Sc in Preventive Medicine, 2001-2006, Nanjing Medical University, Nanjing, PR China
l Ph.D in Toxicology, 2006-2011, Nanjing Medical University, Nanjing, PR China
Working Experiences
l Lecturer, 2011-2016, Nanjing Medical University, Nanjing, PR China
l Visiting scholar, 2010-2011, University of Nebraska Medical Center, USA
l Associated Professor, 2016-2022, Nanjing Medical University, Nanjing, PR China
l Visiting scholar, 2018-2019, Harvard Medical School, USA
l Professor, 2022-now, Nanjing Medical University, Nanjing, PR China
Honors and Awards:
l 2018, the key member of “Qing-Lan Project” of Jiangsu Province
l 2022, the Academic leader of “Qing-Lan Project” of Jiangsu Province
Ongoing Research Projects
l PI, Methamphetamine induced accumulation of Alzheimer's disease associated pathological protein: the roles of Syntaxin17 signaling axis in autophagosome-lysosome fusion. NSFC, 82073584
l PI, Methamphetamine induced Alzheimer's disease-like pathological proteins aggregation: Disorders of autophagosome-lysosome fusion. NSFJP, BK20191349
l PI, Depression in adolescents: tryptophan pathways in gut-brain axis. Major basic science research projects of colleges and universities in Jiangsu Province.
l PI, The Academic leader of “Qing-Lan Project” of Jiangsu Province
Selected Papers
1. Zhu Y, Wang X, Hu M, Yang T, Xu H, Kang X, Chen X, Jiang L, Gao R, Wang J*. Targeting Aβ and p-Tau Clearance in Methamphetamine-Induced Alzheimer's Disease-Like Pathology: Roles of Syntaxin 17 in Autophagic Degradation in Primary Hippocampal Neurons. Oxid Med Cell Longev. 2022,2022:3344569.
2. Tao L, Hu M, Zhang X, Wang X, Zhang Y, Chen X*, Tang J*, Wang J*. Methamphetamine-mediated dissemination of β-amyloid: Disturbances in endocytosis, transport and clearance of β-amyloid in microglial BV2 cells. Toxicol Appl Pharmacol. 2022,447:116090.
3. Xu H, Zhu Y, Chen X, Yang T, Wang X, Song X, Xie X, Hu M, Jiang L, Cheng J, Gao R, Wang J*. Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein-dynactin driving and autophagosome-late endosome/lysosome fusion. Arch Toxicol. 2021, 95(10):3263-3284.
4.Tingwei Wang , Chunyang Xu, Shiying Xu, Lu Gao, Ivana Blaženović , Jian Ji*, Jun Wang*, Xiulan Sun*. Untargeted metabolomics analysis by gas chromatography/time-of-flight mass spectrometry of human serum from methamphetamine abusers.Addict Biol. 2021, 26(6) ：e13062.
5. Pengbo Shi, Zhaosu Li, Teng He, Nanqin Li, Xing Xu, Peiyao Yu, Xue Lu, Jiaxun Nie, Dekang Liu, Qinglong Cai, Yun Guan, Feifei Ge*, Jun Wang*, Xiaowei Guan*. Astrocyte-selective STAT3 knockdown rescues methamphetamine withdrawal-disrupted spatial memory in mice via restoring the astrocytic capacity of glutamate clearance in dCA1. Glia. 2021, 69(10):2404-2418.
6.Deng Y, Zhou M, Wang J, Yao J, Yu J, Liu W, Wu L, Wang J*, Gao R*. Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain. Gut Microbes. 2021;13(1):1-16.
7.Wang J, Yu P, Xie X, Wu L, Zhou M, Huan F, Jiang L, Gao R*. Bisphenol F induces nonalcoholic fatty liver disease-like changes: Involvement of lysosome disorder in lipid droplet deposition. Environ Pollut. 2021,271:116304.
8.Zhu Y, Huan F, Wang J, Xie X, Yu G, Wang X, Jiang L, Gao R, Xiao H, Ding H*, Wang J*. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis. ACS Chem Neurosci. 2020,11(20):3366-3376.
9.Yang T, Zang S, Wang Y, Zhu Y, Jiang L, Chen X, Zhang X, Cheng J, Gao R, Xiao H, Wang J*. Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis. Toxicol Lett. 2020 ,333:150-158.
10.Yao J, Wang J, Wu L, Lu H, Wang Z, Yu P, Xiao H, Gao R*, Yu J*. Perinatal exposure to bisphenol A causes a disturbance of neurotransmitter metabolic pathways in female mouse offspring: A focus on the tryptophan and dopamine pathways. Chemosphere. 2020,254:126715.
