Professor of Department of Toxicology, Nanjing Medical University
sunmk@njmu.edu.cn
孙明宽博士
Sun, Mingkuan PhD
Research Interest
Gene-Environment Interactions in Neuro developmental and Neuro degenerative Disorders
Education(in reverse chronological order)
· Southeast University//Nanjing, Jiangsu 2002-2009
Ph.D., Genetics
· Ludong University//Yantai, Shandong 2000-2002
BS. Biology
Professional Experience(in reverse chronological order)
· School of Public health Nanjing Medical University // Nanjing, Jiangsu 2021-Present
Professor, Neurotoxicology
· Medical School - University of Minnesota// Minneapolis, MN 2020-2021
Researcher6, Neuropathology
· Johns Hopkins University School of Medicine//Baltimore, MD 2019-2020
Research Specialist II, Neuropathology
· Johns Hopkins University School of Medicine//Baltimore, MD 2013-2019
Postdoctoral Fellow, Neuropathology
· Southeast University//Nanjing, Jiangsu 2011-2015
Lecturer
· Southeast University//Nanjing, Jiangsu 2009-2011
Postdoctoral Fellow, Biomedical engineering
Honors andAwards
1. 2021 The Jiangsu Specially-Appointed professor（Jiangsu Education Department）
2. 2019 National Major Talent Program Category A (Young Scholars)
Ongoing Research Projects
1. Establishing animal models of social disorder and identifying key brain regions (Science and Technology Innovation 2030, 2021ZD0204001), 2021.12-2026.11
2. Using Drosophila as a Model to Study the Effects of Toxic Compounds and Heavy Metals on Neurodevelopment and Behavior (Nanjing Medical University, NMUR20210002), 2021.04-2026.03
Selected Papers
1. Qian Li#, Yan Chen#, Weixi Feng, Jiachen Cai, Junying Gao, Feifei Ge, Tiantian Zhou, Ze Wang, Fengfei Ding, Charles Marshall, Chengyu Sheng, Yongjie Zhang, Mingkuan Sun, Jingping Shi, Ming Xiao*, (2022) Drainage of senescent astrocytes from brain via meningeal lymphatic routes. Brain Behavior and Immunity. 2022, 103:85-96.
2. Donde A#, Sun M#, Jeong Y#, Wen X, Ling JP, Lin S, Braunstein K, Nie S, Wang S, Chen L* and Wong PC*. Upregulation of Atg7 attenuates motor neuron dysfunction associated with depletion of TDP-43. Autophagy. 2020, 16(4):672-682.
3. Donde A#, Sun M#, Ling JP, Braunstein K, Pang B, Wen X, Cheng X, Chen L* and Wong PC*. Splicing Repression is a Major Function of TDP-43 in Motor Neurons. Acta Neuropathol. 2019, 138(5):813-826
4. Sun M#, Bell W#, LaClair KD#, Ling JP, Han H, Kageyama Y, Pletnikova O, Troncoso JC, Wong PC, Chen LL. Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43. Acta Neuropathol. 2017, 133(6):923-31.
5. Sun M and Chen LL . A Novel Method to Model Chronic Traumatic Encephalopathy in Drosophila. J. Vis. Exp. 2017 (125), e55602.
6. Sun M, Zeng X, Xie W. Temporal and spatial expression of Drosophila neurexin during the life cycle visualized using a DNRX-Gal4/Uas-reporter. Sci China Life Sci. 2016, 59 (1): 68-77.
7. Sun M and Chen L. Studying tauopathies in Drosophila: A fruitful model. Exp Neurol. 2015, 274(Pt A):52-7.
8. Tian Y, Li T, Sun M, Wan D, Li Q, Li P, Zhang ZC, Han J, Xie W. Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron. 2013,77, 311-22.
9. Sun M, Xing G, Yuan L, Gan G, Knight D, With SI, He C, Han J, Zeng X, Fang F, Boulianne GL, and Xie W. Neuroligin 2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction. J Neurosci. 2011, 31, 687– 699.
