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陈峰


 

生物统计学博士、教授、博士生导师。现任中国卫生信息学会(原中国卫生统计学会)统计理论与方法专业委员会主任委员,国际生物统计学会中国分会(IBS-China)副理事长,中国临床试验统计学组(CCTS working group)组长,《中国卫生统计》杂志副主编,我国临床试验生物统计学指导原则主要起草人之一,ICSA会员。曾留学英国伦敦大学和美国哈佛大学。江苏省有突出贡献的中青年专家,江苏省优秀教育工作者,江苏省第八、九、十届政协委员。主要从事非独立数据、生物医学高维数据、临床试验评价和分析中的统计理论与方法。

 

承担课题

1.        主持国家重点研发计划·战略性国际科技创新合作重点专项:基于出生队列的重金属暴露与不良出生结局的国际合作研究(2016YFE0204900

2.        主持国家自然科学基金重点项目:基于人群的生物医学多层面数据整合方法及肿瘤风险预测研究(81530088

3.        主持国家自然科学基金项目:全基因组关联研究中基因-基因、基因-环境交互作用统计分析方法研究 (81473070)

4.        主持国家自然科学基金项目:全基因组关联研究中的降维策略和统计分析方法研究(81072389)

5.        主持江苏省高校自然科学基金重大项目:全基因组关联研究中的优化设计与降维分析策略(10KJA33034)

6.        主持国家自然科学基金项目:非传统病例对照设计的统计分析方法研究(30571619)

7.        主持教育部博士点基金:微阵列数据的统计分析(20050312001)

8.        主持国家自然科学基金青年基金项目(39500127)《医学研究中非独立数据的统计分析方法》

9.        参与主持国家自然科学基金课题(39470644)《疾病时空聚集性分析方法的研究》

 

教材和著作

1.        共同主编:《临床试验精选案例统计学解读》,人民卫生出版社,2015

2.        编:《医用多元统计分析方法》(第一、二版)教育部研究生推荐教材),中国统计出版社,2001,2007

3.        编:《现代医学统计方法与STATA应用》(第一、二版)中国统计出版社,1999,2003

4.        共同主编:《医学统计学》(陆守曾、陈峰主编) 二版(十一五国家规划教材,中国统计出版社,2002,2007

5.        共同主编:《医用统计方法》(金丕焕、陈峰主编)(第三版)十一五国家规划教材复旦大学出版社,2009

6.        共同主编:《卫生统计学》(赵耐青、陈峰主编)高等教育出版社十一五国家规划教材2008

7.        副主编:《医学科研方法学》(刘民主编),人民卫生出版社,2013

8.        副主编:《临床医学研究设计和数据分析》(赵乃青主编),复旦大学出版社,2005

9.        副主编:《医学统计学》(赵乃青主编)十五国家规划教材,高等教育出版社,2004

10.     副主编:《卫生统计方法应用进展》(饶克勤主编),第1卷、第2卷。人民卫生出版社,2008

11.     副主编:《出生缺陷的统计监测方法与季节性分析》(杨树勤主编),四川科学技术出版社,1998

 

部分SCI收录论文

1.          Shen S, Wang G, Shi Q, Zhang R, Zhao Y, Wei Y, Chen F*, Christiani DC. Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma. Clin Epigenetics. 2017 Aug 24;9:88.

2.          Duan WW, Chen F.W, Zhao Y, Wei Y, Yang S, Bai J, Shen S4, Du M, Huang L. A fast algorithm for Bayesian multi-locus model in genome-wide association studies. Mol Genet Genomics. 2017 Aug;292(4):923-934.

3.          Wu Q, Guo L, Jiang F, Li L, Li Z, Chen F*. Analysis of the miRNA-mRNA-lncRNA networks in ER+ and ER- breast cancer cell lines. J Cell Mol Med. 2015 Dec;19(12):2874-87

4.          Ping Zeng, Yang Zhao, Jin Liu, Liya Liu, Liwei Zhang, Ting Wang, Shuiping Huang and Feng Chen*. Likelihood Ratio Tests in Rare Variant Detection for Continuous Phenotypes. Annals of Human Genetics. 2014, 78:320–332

5.          Jianwei Gou, Yang Zhao, Yongyue Wei, Chen Wu, Ruyang Zhang, Yongyong Qiu, Ping Zeng, Wen Tan, Dianke Yu, Tangchun Wu, Zhibin Hu, Dongxin Lin, Hongbing Shen and Feng Chen*. Stability SCAD: a powerful approach to detect interactions in large-scale genomic study. BMC Bioinformatics 2014, 15:62

6.          Ruyang Zhang, Minjie Chu, Yang Zhao, Chen Wu, Huan Guo, Yongyong Shi, Juncheng Dai, Yongyue Wei, Guangfu Jin, Hongxia Ma, Jing Dong, Honggang Yi, Jianling Bai, Jianhang Gong, Chongqi Sun, Meng Zhu, Tangchun Wu, Zhibin Hu, Dongxin Lin, Hongbing Shen and Feng Chen*. A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.  Carcinogenesis 2014: 35(7):1528-35

7.          Ping Zeng, Yongyue Wei, Yang Zhao, Jin Liu, Liya Liu, Ruyang Zhang, Jianwei Gou, Shuiping Huang & Feng Chen*. Variable selection approach for zero-inflated count data via adaptive lasso. Journal of Applied Statistics. 2014 ,41: 879–894

8.          Hui Dai, Yang Zhao, Cheng Qian, Min Cai, Ruyang Zhang, Minjie Chu, Juncheng Dai, Zhibin Hu, Hongbing Shen, Feng Chen*. Weighted SNP Set Analysis in Genome-Wide Association Study. PLoS One.2013, 8(9): e75897

9.          Minjie Chu, Ruyang Zhang, Yang Zhao, Chen Wu, Huan Guo, Baosen Zhou, Jiachun Lv, Yongyong Shi, Juncheng Dai, Guangfu Jin, Hongxia Ma, Jing Dong, Yongyue Wei, Cheng Wang, Jianhang Gong, Chongqi Sun, Meng Zhu, Yongyong Qiu, Tangchun Wu, Zhibin Hu, Dongxin Lin, Hongbing Shen and Feng Chen*. A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung. cancer susceptibility in Han Chinese. Carcinogenesis 2013:

10.       Min Cai, Hui Dai, Yongyong Qiu, Yang Zhao, Ruyang Zhang, Minjie Chu, Juncheng Dai, Zhibin Hu, Hongbing Shen, Feng Chen*. SNP Set Association Analysis for Genome-Wide Association Studies. PLoS One.2013, 8(5): e62495

11.       Ruyang Zhang, Yang Zhao, Minjie Chu, Chen Wu, Guangfu Jin, Juncheng Dai, Cheng Wang, Lingmin Hu, Jianwei Gou, Chen Qian, Jianling Bai, Tangchun Wu, Zhibin Hu, Dongxin Lin, Hongbing Shen, Feng Chen*. Pathway Analysis for Genome-Wide Association Study of Lung Cancer in Han Chinese Population. PLoS ONE 8(3): e57763

12.       Zhang R, Zhao Y, Chu M, Mehta A, Wei Y, Liu Y, Xun P, Bai J, Yu H, Su L, Zhang H, Hu Z, Shen H, Chen F*, Christiani DC. A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure. PLoS One. 2013;8(3):e59035.

13.       Guo L, Ji X, Yang S, Hou Z, Luo C, Fan J, Ni C, Chen F*; Genome-wide analysis of aberrantly expressed circulating miRNAs in patients with coal workers' pneumoconiosis. Mol Biol Rep. 40(5):3739-47.

14.       Zhibin Hu, Chen Wu, Yongyong Shi, Huan Guo, Xueying Zhao, Zhihua Yin, Lei Yang, Juncheng Dai, Lingmin Hu, Wen Tan, Zhiqiang Li, Qifei Deng, Jiucun Wang, Wei Wu, Guangfu Jin, Yue Jiang, Dianke Yu, Guoquan Zhou, Hongyan Chen, Peng Guan, Yijiang Chen, Yongqian Shu, Lin Xu, Xiangyang Liu, Li Liu, Ping Xu, Baohui Han, Chunxue Bai, Yuxia Zhao, Haibo Zhang, Ying Yan, Hongxia Ma, Jiaping Chen, Mingjie Chu, Feng Lu, Zhengdong Zhang, Feng Chen, Xinru Wang, Li Jin, Jiachun Lu, Baosen Zhou, Daru Lu, Tangchun Wu, Dongxin Lin & Hongbing Shen. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nature Genetics. 2102. (IF=36.377)

15.       Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X, Yang P. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol. 2010 Apr;11(4):321-30. Epub 2010 Mar 19.

16.       Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol. 2010 May 10;28(14):2445-51. Epub 2010 Apr

17.       Yu XJ, Xun PC, Hu ZB, Liu P, Shen HB, Chen F*. Combining previously published studies with current data in Bayesian logistic regression model: an example for identifying susceptibility genes related to lung cancer in humans. J Toxicol Environ Health A. 2009;72(11):683-9.

18.       Bai JL, Zheng MH, Xia X, Ter-Minassian M, Chen YP, Chen F*. MTHFR C677T polymorphism contributes to prostate cancer risk among Caucasians: A meta-analysis of 3511 cases and 2762 controls. Eur J Cancer. 2009 Feb 13

19.       Bai J, Dai J, Yu H, Shen H, Chen F*. Cigarette smoking, MDM2 SNP309, gene-environment interactions, and lung cancer risk: a meta-analysis. J Toxicol Environ Health A. 2009;72(11):677-82

20.       Lu Wang; Pengcheng Xun; Yang Zhao; Xinru Wang; Ling Qian; Feng Chen*. Effects of Lead Exposure on Sperm Concentrations and Testes Weight in Male Rats: A Meta-regression Analysis. Journal of Toxicology and Environmental Health, Part A . 2008; 71: 454–463

21.       Pengcheng Xun, Feng Chen*, Chen Dong, Guohua Qian, Dejian Lai, Jihong Meng. A Score Method for Comparison of Partial Genomic Regions in Their Representatives of Full-Length Genome of Hepatitis E Virus for Genotyping. Intervirology, 2007;50:328–335

22.       Yang Zhao, Lu Wang, Hong-Bing Shen,Zhong-Xu Wang, Qing-Yi Wei, Feng Chen*. Association Between d-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism and Blood Lead Levels: A Meta-regression Analysis. Journal of Toxicology and Environmental Health, Part A, 70: 1–9, 2007

23.       Feng Chen*Qiguang ChenCurrent Status of Statistical Requirements for Clinical Trials in China. ICSA  Bulletin, 200624~31

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