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您现在的位置: 南京医科大学公共卫生学院 >> 院系介绍 

吴炜

吴炜,博士/博士后,副教授,硕士生导师。江苏省毒理学会青年委员会秘书长,南京医科大学青年教师教学研究会副会长。

主要研究领域为生殖和发育毒理学,在EDCs的生殖内分泌毒性及其机制、男性不育的病因学及其机制、新生儿出生体重异常的病因及防治等研究方向开展了部分研究工作,取得了有意义的研究成果。近年来主持国家自然科学基金面上项目、青年基金项目、中国博士后基金面上项目、特别资助项目、江苏省自然科学基金青年基金项目、江苏省高校自然科学基金项目等10余项,并作为主要成员参加国家重点研发计划项目、国家973课题、国家自然科学基金重点项目等。共发表SCI收录论文50余篇(其中第一作者/通讯作者26篇),并被Nature Reviews UrologyHuman Reproduction Update等本领域权威杂志和多本专业书籍引用700次。多次受邀参加国内外学术会议,并作大会发言和墙报展示。目前担任JSM Invitro Fertilization副主编,Scientific ReportsSM Journal of Environmental Toxicology等14本国际刊物编委和《中国循证医学杂志》第一届青年编委会编委,同时担任Human ReproductionBMC Medical GenomicsJournal of Assisted Reproduction and GeneticsSCI杂志特邀审稿人。近年来获教育部自然科学奖二等奖1项、中国毒理学会优秀论文奖”1项;参编中文专著《中华医学百科全书-毒理学卷》及英文专著《Genital Infection and Infertility》和《Spermatozoa。申请国家发明专利10件,已获授权8件;获得软件著作权3件。

讲授卫生毒理学现代毒理学7门课程。致力于卫生毒理学移动学习辅助教学平台建设与研究,主持省级教改课题3项、校级教改课题1项,指导本科生获得省大创项目2项、省级优秀毕业团队2项、七年制优秀科研设计奖”2项,指导本科生作为第一作者发表SCI收录论文3篇。2014年入选校优秀中青年教师支持计划,2015年获校优秀兼职班主任,2016年获得赵息保青年教师奖教金,2017年获全国高校微课教学比赛一等奖。

代表性论文*通讯作者)

1.         Yuan B, Wu W*, Chen M, Gu H, Tang Q, Guo D, Chen T, Chen Y, Lu C, Song L, Xia Y, Chen D, Rehan V, Sha J, Wang X. Metabolomics reveals a role of betaine in prenatal DBP exposure-induced epigenetic transgenerational failure of spermatogenesis in rats. Toxicol Sci. 2017; In press. IF = 4.08

2.         Gu H, Wu W*, Yuan B, Tang Q, Guo D, Chen Y, Xia Y, Hu L, Chen D, Sha J, Wang X. Genistein up-regulates miR-20a to disrupt spermatogenesis via targeting Limk1. Oncotarget. 2017; doi: 10.18632/oncotarget.17637.IF = 5.17

3.         Guo D, Wu W*, Tang Q, Qiao S, Chen Y, Chen M, Teng M, Lu C, Ding H, Xia Y, Hu L, Chen D, Sha J, Wang X. The impact of BMI on sperm parameters and the metabolite changes of seminal plasma concomitantly. Oncotarget. 2017; doi: 10.18632/oncotarget.14950. IF = 5.17

4.         Hu W, Chen M, Wu W*, Lu J, Zhao D, Pan F, Lu C, Xia Y, Hu L, Chen D, Sha J, Wang X. Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. Environ Int. 2016; 91:188-195. (IF = 7.09)

5.         Yuan B, Gu H, Xu B, Tang Q, Wu W*, Ji X, Xia Y, Hu L, Chen D, Wang X. Effects of Gold Nanorods on Imprinted Genes Expression in TM-4 Sertoli Cells. Int J Environ Res Public Health. 2016; 13(3). pii: E271.  (IF = 2.10)

6.         Lu J, Gu H, Tang Q, Wu W*, Yuan B, Guo D, Wei Y, Sun H, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Common SNP in hsa-miR-196a-2 increases hsa-miR-196a-5p expression and predisposes to idiopathic male infertility in Chinese Han population. Sci Rep. 2016; 6:19825.  (IF = 4.26)

7.         Li J, Chen L, Tang Q, Wu W*, Gu H, Liu L, Wu J, Jiang H, Ding H, Xia Y, Chen D, Hu Y, Wang X. The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia. Sci Rep. 2015; 5:17212.  (IF = 5.228)

8.         Ju R, Wu W (co-first author), Tang Q, Wu D, Xia Y, Wu J, Wang X. Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population. PLoS One. 2015; 10(10):e0140326.  (IF = 3.057)

9.         Ju R, Wu W (co-first author), Fei J, Qin Y, Tang Q, Wu D, Xia Y, Wu J, Wang X. Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population. Eur J Endocrinol. 2015; 172(3):227-33.  (IF = 3.892)

10.     Zhao M, Tang Q, Wu W*, Xia Y, Chen D, Wang X. miR-20a contributes to endometriosis by regulating NTN4 expression. Mol Biol Rep. 2014; 41(9):5793-7.   (IF = 2.024)

11.     Jiang H, Wu W (co-first author), Zhang M, Li J, Peng Y, Miao T, Zhu H, Xu G. Aberrant upregulation of miR-21 in placental tissues of macrosomia. J Perinatol. 2014; 34(9):658-63.  (IF = 2.072)

12.     Zhang S, Tang Q, Wu W*, Yuan B, Lu C, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis. Sci Rep. 2014; 4:4642.  (IF = 5.578)

13.     Wu W*, Lu J, Tang Q, Zhang S, Yuan B, Li J, Di Wu, Sun H, Lu C, Xia Y, Chen D, Sha J, Wang X. GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects. Sci Rep. 2013; 3:2258.  (IF = 5.078)

14.     Wu W*, Lu J, Chen D, Yuan B, Qin Y, Han X, Niu X, Xu B, Lu C, Xia Y, Sha J, Wang X. Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. Gene. 2013; 524:197-202.  (IF = 2.082)

15.     Wu W, Qin Y, Li Z, Dong J, Dai J, Lu C, Guo X, Zhao Y, Zhu Y, Zhang W, Sha J, Shen H, Xia Y, Hu Z, Wang X. Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p. Hum Reprod. 2013; 28:1827-36.  (IF = 4.585)

16.     Qin Y, Chen M, Wu W (co-first author), Xu B, Tang R, Chen X, Du G, Lu C, Meeker JD, Zhou Z, Xia Y, Wang X. Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility. PLoS One. 2013;8:e59398.  (IF = 3.534)

17.     Tang Q, Wu W (co-first author), Xu X, Huang L, Gao Q, Chen H, Sun H, Xia Y, Sha J, Wang X, Chen D, Xu Q. miR-141 Contributes to Fetal Growth Restriction by Regulating PLAG1 Expression. PLoS One. 2013;8:e58737.  (IF = 3.534)

18.     Wu W, Hu Z, Qin Y, Dong J, Dai J, Lu C, Zhang W, Shen H, Xia Y, Wang X. Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol Hum Reprod. 2012; 18:489-497.  (IF = 4.542)

19.     Wu W, Shen O, Qin Y, Lu J, Niu X, Zhou Z, Lu C, Xia Y, Song L, Wang S, Wang X. Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis. Int J Androl. 2012; 35:18-24.  (IF = 3.565)

20.     Shen O, Wu W (co-first author), Du G, Liu R, Yu L, Sun H, Han X, Jiang Y, Shi W, Hu W, Song L, Xia Y, Wang S, Wang X. Thyroid Disruption by Di-n-Butyl Phthalate (DBP) and Mono-n-Butyl Phthalate (MBP) in Xenopus laevis. PLoS One. 2011; 6:e19159.  (IF = 4.092)

21.     Wu W, Shen O, Qin Y, Niu X, Lu C, Xia Y, Song L, Wang S, Wang X. Idiopathic Male Infertility Is Strongly Associated with Aberrant Promoter Methylation of Methylenetetrahydrofolate Reductase (MTHFR). PLoS One. 2010; 5: e13884.  (IF = 4.411)

22.     Wu W, Lu C, Xia Y, Shen O, Ji G, Gu A, Song L, Wang X. Lack of association between DAZ gene methylation patterns and spermatogenic failure. Clin Chem Lab Med. 2010; 48: 355-360.  (IF = 2.069)

 

 

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