钱旭

发布者:流行病学系发布时间:2018-10-08浏览次数:3474


钱旭

男,博士,教授,博士生导师,南京医科大学学术带头人。2003年就读于中国药科大学生物工程专业,2013年就读于南京医科大学病理系获博士学位,2013年至2018年在美国德克萨斯大学MD安德森癌症中心从事博士后研究。20189月加入公共卫生学院流行病学系担任教授。曾获得MD安德森癌症中心Endowed Fellowship Award学术奖励,参与获得中华医学科技奖三等奖、江苏省科学技术奖二等奖、江苏医学科技奖二等奖等。主要从事肿瘤代谢与肿瘤分子流行病学研究,已在Cancer discoveryMolecular CellNature Cell Biology等国际主流学术期刊以第一作者或共同作者发表研究论文30余篇。

  

研究方向:肿瘤代谢与肿瘤分子流行病学

  

联系方式:

地址:南京市江宁区龙眠大道101

邮箱:xqianmedres@njmu.edu.cn

  

代表性论文:

1.Li X*Qian X*, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, Lu Z. Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication. Mol Cell.* Co-first author,已接收)

2.Qian X*, Li X*, Tan L, Lee JH, Xia Y, Cai Q, Zheng Y, Wang H, Lorenzi PL, Lu Z. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discov.2018;8(1):94-107.

3.Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell. 2017;65(5):917-931.e6.

4.Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z. EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Mol Cell. 2018;70(2):197-210.e7.

5.Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017;66(5):684-697.e9.

6.Li X, Qian X, Peng LX, Jiang Y, Hawke D, Zheng Y, Xia Y, Lee JH, Cote G, Wang H, Wang L, Qian CN, Lu Z: A splicing Switch from Ketohexokinase-C to Ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol. 2016;18:561-71.

7.Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY and Lu Z. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol. 2015;17:1158-68.

8.Zheng Y, Li X, Qian X, Wang Y, Lee JH, Xia Y, Hawke DH, Zhang G, Lyu J and Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nat Cell Biol. 2015;17:1348-55.